[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658359":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":17,"studyPopulation":21,"armGroups":17,"interventions":17,"overallOfficials":17,"centralContacts":17,"locations":17,"responsibleParty":22,"collaborators":17,"id":24,"slug":25,"hasResults":26,"nctId":27,"briefTitle":28,"officialTitle":29,"acronym":30,"eligibilityCriteria":31,"healthyVolunteers":32,"sex":33,"minAge":34,"maxAge":35,"enrollmentInfo":36,"targetDuration":39,"studyType":40,"phases":17,"briefSummary":41,"conditions":42,"keywords":46,"overallStatus":50,"whyStopped":17,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":17},{"fullName":5,"class":6},"Paediatric Neuroimaging Research Group","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"FMRI connectivity","Differences in functional connectivity of spontaneous fMRI brain activity","Two years",[14],{"measure":15,"description":16,"timeFrame":12},"Changes in fMRI connectivity","Longitudinal changes in fMRI connectivity over the entire duration of the study",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"COHORT","PROSPECTIVE","Participants in this study will be infants born at the John Radcliffe Hospital, Oxford at or after 35+0 weeks gestation with a postnatal age of \\\u003C7 days.",{"type":23,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100658359","memri-memory-emergence-using-mri-100658359",false,"NCT07849075","MEMRI: Memory Emergence Using MRI","Emergence of Distinct Cortical Anatomy Associated With the Human Medial Temporal Lobe in the First Two Years of Life Revealed Using Precision High-resolution Neuroimaging at 7-Tesla","MEMRI","Inclusion Criteria:\n\n* Infants born at the John Radcliffe Hospital, Oxford\n* Infants born at or after 35+0 weeks gestation\n* Infants with a postnatal age of \\\u003C7 days\n* Infants for whom parents\u002Flegal guardians have given written informed consent for participation.\n\nExclusion Criteria:\n\n* Hypoxic Ischaemic Encephalopathy (HIE)\n* Intraventricular haemorrhage (IVH) \\> grade II\n* Received any analgesics or sedatives in the last 24 hours\n* Congenital malformation or genetic condition known to affect neurological development\n* Born to mothers who have a history of substance abuse\n* Any MRI contradictions",true,"ALL","0 Weeks","1 Week",{"count":37,"type":38},20,"ESTIMATED","26 Months","OBSERVATIONAL","Episodic memory is our ability to remember personal experiences, such as a birthday party or a visit to the park. This study aims to understand how this type of memory develops during the first two years of a baby's life. Researchers will use a safe, non-invasive brain scanning technique called magnetic resonance imaging (MRI) to study healthy babies from birth until they are two years old. By following the same children over time, researchers will see how the brain's memory system develops and how it becomes connected with other parts of the brain. The findings will help us understand how babies develop the ability to remember personal experiences. They will also provide new knowledge about how the human brain develops during the earliest stages of life.",[43,44,45],"Not Applicable - Healthy Participants","Focus is the Memory System","Paediatric",[47,48,45,49],"Memory","Neonatal","MRI","NOT_YET_RECRUITING","2026-09-24",{"date":53,"type":54},"2026-09-30","ACTUAL",{"date":56,"type":38},"2027-03-01",{"date":58,"type":38},"2031-07-01",{"name":5,"class":6}]