[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100491618":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":73,"collaborators":30,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":30,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":30,"overallStatus":51,"whyStopped":30,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"University of Alberta","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"KETO-Can","EXPERIMENTAL","KETO diet supplemented with Canola oil (high in MUFA and omega-3 FA).",[13],"Other: Keto-CAN",{"label":15,"type":10,"description":16,"interventionNames":17},"KETO-Sat","KETO diet supplemented with butter and coconut oil (high in SFA).",[18],"Other: Keto-SAT",{"label":20,"type":21,"description":22,"interventionNames":23},"Low fat diet (LFD)","ACTIVE_COMPARATOR","Low fat diet supplemented with whole grain foods (pasta or brown rice) and oatmeal.",[24],"Other: LFD",[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Keto-SAT","Nutrition counselling focused on Keto diet (saturated fat).\n\n10% TE as carbohydrate (mainly from vegetables and whole grain products), protein between 20-30% TE and fat between 60-70%.",[15],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Keto-CAN","Nutrition counselling focused on Keto diet (unsaturated fat).\n\n10% TE as carbohydrate (mainly from vegetables and whole grain products), protein between 20-30% TE and fat between 60-70%.",[9],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"LFD","Nutrition counselling focused on low-fat diet.\n\n30% total energy (TE) as fat, 50% TE as carbohydrates (primarily whole grains) and 17-20% TE protein (mainly lean sources).",[20],[40],{"name":41,"affiliation":5,"role":42},"Catherine Chan, PhD","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},"Paulina Blanco Cervantes, MSc","CONTACT","7804929506","blancoce@ualberta.ca",[50],{"facility":5,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Edmonton","Alberta","T6G 2E1","Canada","CA",{"type":58,"coordinates":59},"Point",[60,61],-113.46871,53.55014,{"lat":61,"lon":60},[64,66,69,70],{"name":45,"role":46,"phone":65,"phoneExt":30,"email":48},"780-492-9506",{"name":41,"role":46,"phone":67,"phoneExt":30,"email":68},"780-492-9939","cbchan@ualberta.ca",{"name":41,"role":42,"phone":30,"phoneExt":30,"email":30},{"name":71,"role":72,"phone":30,"phoneExt":30,"email":30},"Caroline Richard, PhD, RD","SUB_INVESTIGATOR",{"type":74,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100491618","metabolic-and-inflammatory-outcomes-of-the-ketogenic-diet-comparing-saturated-and-unsaturated-fat-sources-100491618",false,"NCT05681468","Metabolic and Inflammatory Outcomes of the Ketogenic Diet Comparing Saturated and Unsaturated Fat Sources","KETO-IM","Inclusion Criteria:\n\n* Having overweight or obesity and HbA1C ≥ 5.7% at screening\n\nExclusion Criteria:\n\n* Individuals with specific nutritional habits preventing them from adhering to nutritional recommendations\n* Pregnant women\n* People on dialysis or recommended to follow a low-protein diet (base on glomerular filtration rate)\n* Familial hypercholesterolemia or hypertriglyceridemia\n* Transitioning trans-gender\n* For safety purposes, other individuals would be excluded if are under unstable health conditions.","ALL","18 Years","70 Years",{"count":86,"type":87},175,"ESTIMATED","INTERVENTIONAL",[90],"NA","The goal of this clinical trial is to compare a healthy KETO diet supplemented with canola oil (KETO-Can) compared to a traditional KETO diet high in saturated fat (KETO-Sat) and low-fat diet (LFD) in adults at high risk of or diagnosed with type 2 diabetes. The main question\\[s\\] it aims to answer are:\n\n* Effects on CVD risk factors (plasma cholesterol, TG, ApoB100, glucose, insulin and HbA1C).\n* Effects on systemic inflammation and immune function.\n* Adherence to interventions.\n\nParticipants will be randomized into 1 of the dietary treatments during which they will follow a Keto or a low-fat diet.\n\nComparisons among groups at 3 and 6 months of intervention will be conducted.",[93,94,95],"PreDiabetes","Diabetes Mellitus, Type 2","Overweight and Obesity","2026-07-14",{"date":98,"type":99},"2026-07-16","ACTUAL",{"date":101,"type":99},"2023-09-18",{"date":103,"type":87},"2027-01-31",{"name":5,"class":6},1]