[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623213":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":21,"studyPopulation":13,"armGroups":22,"interventions":35,"overallOfficials":53,"centralContacts":57,"locations":63,"responsibleParty":78,"collaborators":13,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":84,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":13,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":104,"overallStatus":111,"whyStopped":13,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"West Kazakhstan Marat Ospanov Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Recurrence of infection-related kidney stones","Proportion of patients with recurrent infection-related kidney stones within 12 months after percutaneous nephrolithotripsy, assessed by imaging studies (ultrasound or CT) and clinical evaluation.","12 months post-PCNL",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":17,"primaryPurpose":18,"observationalModel":13,"timePerspective":13,"maskingInfo":19},"RANDOMIZED","PARALLEL","Participants are assigned to receive standard PCNL with or without adjunctive intrarenal dioxidine instillation.","PREVENTION",{"masking":20,"maskingDescription":13,"whoMasked":13},"NONE","Infection-related kidney stones are associated with urease-producing bacteria and carry a high risk of recurrence even after successful surgical removal. Percutaneous nephrolithotripsy (PCNL) is the standard treatment for large or complex renal calculi; however, residual infection and bacterial biofilms may contribute to recurrent stone formation.\n\nMetaphylaxis strategies targeting infection control may reduce recurrence rates. Dioxidine is an antimicrobial agent with broad-spectrum activity against gram-positive and gram-negative bacteria and has been used locally in urological practice. Intrarenal instillation may help reduce bacterial colonization in the collecting system.\n\nThe purpose of this study is to evaluate the clinical effectiveness and safety of intrarenal dioxidine instillation as a metaphylactic intervention after PCNL for infection-related kidney stones. Outcomes include stone recurrence, urinary tract infection rates, and postoperative complications. The results may help define improved metaphylaxis strategies for patients with infection-related nephrolithiasis.",[23,30],{"label":24,"type":25,"description":26,"interventionNames":27},"Intrarenal Dioxidine Group","EXPERIMENTAL","Participants undergo PCNL followed by intrarenal instillation of dioxidine to prevent infection-related stone recurrence.",[28,29],"Drug: Dioxidine","Procedure: Percutaneous Nephrolithotripsy (PCNL)",{"label":31,"type":32,"description":33,"interventionNames":34},"Standard Treatment Group","ACTIVE_COMPARATOR","Participants undergo standard PCNL without adjunctive dioxidine.",[29],[36,44],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"DRUG","Dioxidine","Intrarenal instillation of dioxidine solution after PCNL to reduce bacterial colonization and prevent recurrence of infection-related stones.",[24],[42,43],"Intrarenal Dioxidine Instillation","Dioxidine Solution",{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"PROCEDURE","Percutaneous Nephrolithotripsy (PCNL)","Standard percutaneous nephrolithotripsy procedure for removal of kidney stones.",[24,31],[50,51,52],"PCNL","Percutaneous Stone Removal","Percutaneous Lithotripsy",[54],{"name":55,"affiliation":5,"role":56},"Bazylbek S Zhakiev, MD","STUDY_DIRECTOR",[58],{"name":59,"role":60,"phone":61,"phoneExt":13,"email":62},"Talgat A Imzharov","CONTACT","+77054442410","t.imzharov@zkmu.kz",[64],{"facility":5,"status":13,"city":65,"state":13,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Aqtöbe","030000","Kazakhstan","KZ",{"type":70,"coordinates":71},"Point",[72,73],69.81328,45.01214,{"lat":73,"lon":72},[76],{"name":59,"role":60,"phone":77,"phoneExt":13,"email":62},"87054442410",{"type":79,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Talgat A. Imzharov","Principal Investigator","100623213","metaphylaxis-of-infected-kidney-stones-after-percutaneous-nephrolithotripsy-100623213",false,"NCT07393711","Metaphylaxis of Infected Kidney Stones After Percutaneous Nephrolithotripsy","Evaluation of the Effectiveness of Intrarenal Dioxidine Metaphylaxis for Preventing Recurrence of Infection Stones After Percutaneous Nephrolithotripsy","DIOX-PCNL","Inclusion Criteria:\n\nAge ≥18 years\n\nPatients undergoing percutaneous nephrolithotripsy (PCNL)\n\nInfection-related kidney stones\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nAge \\\u003C18 years\n\nPregnancy or breastfeeding\n\nKnown hypersensitivity to dioxidine\n\nSevere renal insufficiency or end-stage renal disease\n\nSevere comorbid conditions that preclude participation","ALL","18 Years","70 Years",{"count":94,"type":95},95,"ESTIMATED","INTERVENTIONAL",[98],"NA","Kidney stone recurrence, particularly infection-related stones, remains a significant clinical problem after percutaneous nephrolithotripsy (PCNL). Bacterial colonization and persistent infection are recognized contributors to stone recurrence.\n\nThis study evaluates the effectiveness of intrarenal dioxidine instillation as a metaphylactic measure to reduce recurrence of infection-related kidney stones following PCNL. Patients undergoing PCNL will receive standard treatment, with or without adjunctive intrarenal dioxidine administration. The study aims to assess whether this approach reduces stone recurrence and infection-related complications.",[101,102,103],"Kidney Calculi","Nephrolithiasis","Urinary Tract Infections",[105,50,106,107,38,108,109,110],"Percutaneous nephrolithotomy","Infection stones","Struvite stones","Intrarenal instillation","Stone recurrence","Metaphylaxis","NOT_YET_RECRUITING","2026-02-08",{"date":114,"type":115},"2026-02-11","ACTUAL",{"date":117,"type":95},"2026-03-01",{"date":119,"type":95},"2026-12-30",{"name":5,"class":6},1]