[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656540":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":36,"studyPopulation":37,"armGroups":38,"interventions":32,"overallOfficials":42,"centralContacts":47,"locations":32,"responsibleParty":53,"collaborators":32,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":32,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":32,"enrollmentInfo":66,"targetDuration":32,"studyType":69,"phases":32,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":80,"whyStopped":32,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":32},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":32},[9],{"measure":10,"description":11,"timeFrame":12},"Diagnostic accuracy of mFFE MRI for cortical bone changes","Overall diagnostic accuracy percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard","Baseline",[14,17,20,23,26,29],{"measure":15,"description":16,"timeFrame":12},"Sensitivity of mFFE MRI for cortical bone changes","Sensitivity percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard",{"measure":18,"description":19,"timeFrame":12},"Specificity of mFFE MRI for cortical bone changes","Specificity percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard",{"measure":21,"description":22,"timeFrame":12},"Detection of subchondral sclerosis","Number of cases in which mFFE MRI correctly identifies subchondral sclerosis compared with CT",{"measure":24,"description":25,"timeFrame":12},"Detection of osteophytes","Number of cases in which mFFE MRI correctly identifies osteophytes compared with CT",{"measure":27,"description":28,"timeFrame":12},"Detection of joint space narrowing","Number of cases in which mFFE MRI correctly identifies joint space narrowing compared with CT",{"measure":30,"description":31,"timeFrame":12},"Image quality score","Mean subjective image quality score of mFFE MRI for cortical bone visualization on a predefined scale from 1 to 5, with higher scores indicating better image quality",null,{"allocation":32,"interventionModel":32,"interventionModelDescription":32,"primaryPurpose":32,"observationalModel":34,"timePerspective":35,"maskingInfo":32},"COHORT","CROSS_SECTIONAL","Knee osteoarthritis involves microstructural alterations in subchondral and cortical bone. Conventional MRI has limitations in visualizing cortical bone due to short T2 relaxation times. Multi-echo fast field echo (mFFE) sequences can produce CT-like images of cortical bone without ionizing radiation.\n\nThis observational study will include patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis. All participants will undergo both mFFE MRI and CT of the knee. The accuracy of mFFE MRI in detecting cortical bone degenerative changes will be compared with CT as the reference standard.","Patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis attending the Diagnostic and Interventional Radiology Department at Assiut University Hospital.",[39],{"label":40,"type":32,"description":41,"interventionNames":32},"Single cohort: Patients with knee osteoarthritis","Patients aged 40 years or older with knee osteoarthritis who will undergo both multi-echo fast field echo (mFFE) MRI and CT of the knee for comparison of cortical bone evaluation.",[43],{"name":44,"affiliation":45,"role":46},"Ehab M Mohammed, prof","Diagnostic and interventional radiology Department, Assiut University Hospitals","STUDY_CHAIR",[48],{"name":49,"role":50,"phone":51,"phoneExt":32,"email":52},"Fatima M Eltony, Resident","CONTACT","+20 10 15712606","fatima.18313255@med.aun.edu.eg",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Fatima Mahmoud Hammad Eltony","Resident Physician","100656540","mffe-mri-versus-ct-for-cortical-bone-evaluation-in-knee-osteoarthritis-100656540",false,"NCT07827443","mFFE MRI Versus CT for Cortical Bone Evaluation in Knee Osteoarthritis","Beyond Conventional MRI: Multi-Echo Fast Field Echo (mFFE) MRI for Cortical Bone Evaluation in Knee Osteoarthritis Compared With CT","Inclusion Criteria:\n\n* \\- Age 40 years or older\n* Clinically suspected or confirmed knee osteoarthritis\n* Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* \\- Implanted electronic devices (pacemakers, ICDs, neurostimulators, cochlear implants)\n* Metallic foreign bodies in the eyes or orbits\n* Ferromagnetic cerebral aneurysm clips\n* Implantable infusion pumps\n* Pregnancy","ALL","40 Years",{"count":67,"type":68},80,"ESTIMATED","OBSERVATIONAL","This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT.",[72,73],"Osteoarthritis, Knee","Bone Diseases",[75,76,77,78,79],"mFFE MRI","Knee osteoarthritis","Cortical bone","CT-like MRI","Assiut","NOT_YET_RECRUITING","2026-09-14",{"date":83,"type":84},"2026-09-18","ACTUAL",{"date":86,"type":68},"2026-09-15",{"date":88,"type":68},"2028-02-20",{"name":5,"class":6}]