[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650685":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":25,"collaborators":10,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":10,"eligibilityCriteria":33,"healthyVolunteers":29,"sex":34,"minAge":35,"maxAge":10,"enrollmentInfo":36,"targetDuration":39,"studyType":40,"phases":10,"briefSummary":41,"conditions":42,"keywords":10,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":10},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Micro-nanoplastic Exposure and CVOT",null,"According to the baseline circulating MNPs exposure level of the patients, participants will be categorized into the high-exposure group and low-exposure group using the median value as the cutoff point.",[13,14],"Other: micro-nanoplastic examination","Procedure: Microvascular Function Examination",[16,20],{"type":6,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"micro-nanoplastic examination","In this prospective cohort study, the investigators plan to perform a low-contamination protocol for the detection of circulating micro-nanoplastic particles in eligible subjects prior to the administration of invasive coronary angiography and concomitant coronary microvascular function assessment, so as to clarify the impact of micro-nanoplastic exposure status on coronary microvascular function and long-term prognosis.",[9],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Microvascular Function Examination","Using a catheter to perform invasive coronary functional assessment, including flow fraction reserve(FFR), coronary flow reserve (CFR) and index of microcirculation resistance (IMR)",[9],{"type":26,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100650685","micro-nanoplastic-exposure-and-coronary-microcirculatory-dysfunction-as-well-as-cardiovascular-outcomes-100650685",false,"NCT07748767","Micro-nanoplastic Exposure and Coronary Microcirculatory Dysfunction as Well as Cardiovascular Outcomes","Association of Micro-Nanoplastic Exposure With Coronary Microvascular Dysfunction and Subsequent Cardiovascular Outcomes: A Prospective Cohort Study","Inclusion Criteria:\n\n* Age ≥ 18;\n* Patients with clinical indications for undergoing invasive coronary angiography and coronary functional assessment (including fractional flow reserve \\[FFR\\], CFR, and IMR);\n* Voluntarily sign the written informed consent form.\n\nExclusion Criteria:\n\n* The surgeon (or attending physician) determines that the patient is not suitable for or cannot tolerate a coronary physiological examination;\n* Intraoperative coronary angiography reveals a stenosis of\\>90% in any non-left main coronary artery lumen or a stenosis of\\>50% in the left main coronary artery lumen;\n* Left ventricular ejection fraction \\\u003C35% or cardiogenic shock or cardiac arrest;\n* Previous history of invasive procedures\u002Ftreatments;\n* Active inflammatory diseases;\n* Connective tissue disease;\n* History of malignant tumors;\n* Expected lifespan \\\u003C2 years;\n* Pregnancy or lactation;\n* Subjects who refuse to comply with the pollution control measures set in this study;\n* Currently participating in other interventional clinical trials.","ALL","18 Years",{"count":37,"type":38},184,"ESTIMATED","2 Years","OBSERVATIONAL","With strict quality control procedures applied throughout microplastic testing, this study will assess the association between baseline circulating micro-nanoplastic exposure and coronary microvascular dysfunction, as well as subsequent long-term cardiovascular outcomes.",[43,44,45,46],"Coronary Microvascular Dysfunction (CMD)","Microplastic Exposure","Nanoplastics","MACE","NOT_YET_RECRUITING","2026-08-19",{"date":50,"type":51},"2026-08-21","ACTUAL",{"date":53,"type":38},"2027-01-01",{"date":55,"type":38},"2029-12-31",{"name":5,"class":6}]