[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587916":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":22,"locations":31,"responsibleParty":49,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"University of North Carolina, Chapel Hill","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Clear Aligner Treatment",null,"Orthodontic patients already scheduled to receive clear aligner treatment at UNC Orthodontic clinics.",[13],"Other: Clear Aligner Treatment",[15],{"type":6,"name":9,"description":16,"armGroupLabels":17,"otherNames":10},"This study is observational. Only patients who are previously scheduled to receive clear aligner treatment from their orthodontic provider will be recruited.",[9],[19],{"name":20,"affiliation":5,"role":21},"Laura A Jacox, DMD, PhD, MS","PRINCIPAL_INVESTIGATOR",[23,27],{"name":20,"role":24,"phone":25,"phoneExt":10,"email":26},"CONTACT","919-537-3424","ljacox@live.unc.edu",{"name":28,"role":24,"phone":29,"phoneExt":10,"email":30},"S.T. Phillips, BSDH","919-537-3422","sherrill_phillips@unc.edu",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of North Carolina at Chapel Hill","RECRUITING","Chapel Hill","North Carolina","27599","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-79.05584,35.9132,{"lat":44,"lon":43},[47,48],{"name":20,"role":24,"phone":25,"phoneExt":10,"email":26},{"name":20,"role":21,"phone":10,"phoneExt":10,"email":10},{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100587916","microplastic-exposure-from-clear-aligner-wear-mpe-100587916",false,"NCT06934603","Microplastic Exposure From Clear Aligner Wear (MPE)","Microplastic Exposure From Clear Aligner Wear: An In Vivo, Longitudinal Study of Orthodontic Patients","MPE","Inclusion Criteria:\n\n* Individuals (all sexes, genders, races, and ethnicities) aged at least 10 years (in adult dentition) and at most 75 years\n* Receiving comprehensive, Phase II orthodontic treatment with clear aligner therapy\n* Stable physical health (ASA I or II), as determined by study coordinator or PI\n* Able to comprehend and follow requirements of study (including availability on scheduled visit dates)\n* Patient and parental consent (and assent for minors) for participation in the study\n\nExclusion Criteria:\n\n* Receiving orthodontic treatment with fixed appliances\n* Receiving hybrid treatment with fixed appliances and aligners\n* Receiving Phase I orthodontic treatment with fixed appliances\n* Established history of severe xerostomia (dry mouth), severe periodontal disease with actively bleeding gums, significant oral abrasions\u002Fulcers or growths, current alcohol abuse, and\u002For recreational drug abuse\n* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase risk associated with participation\n* Drinking, eating, or brushing teeth within 1 hour of study visit\n* Removing aligners within 1 hour of study visit\n* Developmental or cognitive disability such that the patient cannot self-consent, comprehend, and follow the requirements of the study based on research site personnel's assessment","ALL","10 Years","75 Years",{"count":63,"type":64},150,"ESTIMATED","OBSERVATIONAL","An observational longitudinal study measuring microplastic exposure and physiologic uptake in orthodontic patients receiving clear aligner treatment.",[68],"Microplastic Exposure","2025-09-17",{"date":71,"type":72},"2025-09-19","ACTUAL",{"date":74,"type":72},"2025-08-08",{"date":76,"type":64},"2035-07-01",{"name":5,"class":6},1]