[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648498":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":55,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":26,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":26,"maxAge":26,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention , MINST + IPRF","EXPERIMENTAL","Participants will receive minimally invasive non-surgical periodontal therapy (MINST) with adjunctive local application of injectable platelet-rich fibrin (I-PRF) into the selected periodontal intrabony defect. I-PRF will be prepared from 10 mL of autologous venous blood and injected into the cleaned defect, followed by placement of a custom-made transparent vacuum-formed stent for 15 minutes to prolong local contact. Participants will receive standard oral hygiene instructions and periodontal follow-up.",[13],"Biological: Injectable PRF",{"label":15,"type":16,"description":17,"interventionNames":18},"Control , MINST only","ACTIVE_COMPARATOR","Participants will receive minimally invasive non-surgical periodontal therapy (MINST) alone for the selected periodontal intrabony defect, without adjunctive I-PRF or other biomaterials. Participants will receive standard oral hygiene instructions and periodontal follow-up.",[19],"Procedure: MINST",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Injectable PRF","I-PRF will be prepared from 10 mL of autologous venous blood and injected into the cleaned defect, followed by placement of a custom-made transparent vacuum-formed stent for 15 minutes to prolong local contact",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","MINST","Participants will receive minimally invasive non-surgical periodontal therapy (MINST) alone using P3 Woodpecker piezoelectric scaler for the selected periodontal intrabony defect",[15],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Hania Haggag","CONTACT","+01210239417","hania.haggag@dentistry.cu.edu.eg",[39],{"facility":5,"status":40,"city":41,"state":26,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Cairo","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.24967,30.06263,{"lat":48,"lon":47},[51],{"name":52,"role":35,"phone":53,"phoneExt":26,"email":54},"Faculty of dentistry Cairo university","+01002159535","dentmail@dentistry.cu.edu.eg",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Hania wael","Master degree candidate","100648498","minimally-invasive-non-surgical-treatment-using-injectable-platelet-concentrate-in-treatment-of-deep-pockets-100648498",false,"NCT07722390","Minimally Invasive Non Surgical Treatment Using Injectable Platelet Concentrate in Treatment of Deep Pockets.","The Effect of Adjunctive I-PRF on the Outcomes of Minimally-invasive Non-surgical Therapy of Periodontal Intrabony Defects.A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with periodontitis stage III-IV.\n* Presence of at least one intrabony defect with radiographic component ≥ 3mm deep and PPD≥ 6mm (not affecting a tooth with 'hopeless' prognosis).\n* Patients willing to sign informed consent and to be in the study until the 6-months follow-up.\n* Full-mouth plaque score \\\u003C30% following step 1 periodontal therapy\n\nExclusion Criteria:\n\n* Smoker\u002Fvaper (currently or in past 5 years).\n* Contributory medical history (e.g. cardiovascular disease, diabetes, psychiatric conditions).",true,"ALL",{"count":69,"type":70},48,"ESTIMATED","INTERVENTIONAL",[73],"NA","The purpose of this study is to evaluate change in pocket depth following using minimally invasive non surgical combined with injectable platelet concentrate .",[76],"Intrabony Periodontal Defects",[78],"intrabony defect - MINST - IPR-F","2026-07-28",{"date":81,"type":82},"2026-07-29","ACTUAL",{"date":84,"type":82},"2025-05-14",{"date":86,"type":70},"2028-06",{"name":5,"class":6},1]