[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632160":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":46,"responsibleParty":69,"collaborators":72,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":32,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":100,"whyStopped":32,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"The University of Texas Health Science Center at San Antonio","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment group taVNS","EXPERIMENTAL","Treatment with transauricular vagus nerve stimulation (taVNS) after admission to trauma with a traumatic brain injury (TBI)",[13],"Device: Nurosym taVNS",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","SHAM_COMPARATOR","The control group will undergo sham stimulation using the same device placed at the same location with a brief, low level stimulation that tapers over 30 seconds.",[19],"Device: Nurosym (sham)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Nurosym taVNS","Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation technique that electrically stimulates the auricular branch of the vagus nerve via electrodes placed on the tragus of the ear.",[9],[27],"Vagal nerve stimulator",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Nurosym (sham)","Patients will have the device placed on their tragus and will receive a low level of stimulation that tapers to zero over 30 seconds.",[15],null,[34],{"name":35,"affiliation":5,"role":36},"Michael McGinity, MD","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":42},"Patrick Thompson","CONTACT","817-807-6006","thompsonp4@livemail.uthscsa.edu",{"name":35,"role":40,"phone":44,"phoneExt":32,"email":45},"210 567 5823","McGinity@uthscsa.edu",[47,64],{"facility":48,"status":32,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"University Hospital","San Antonio","Texas","78229","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-98.49363,29.42412,{"lat":58,"lon":57},[61,63],{"name":39,"role":40,"phone":62,"phoneExt":32,"email":42},"8178076006",{"name":35,"role":40,"phone":44,"phoneExt":32,"email":45},{"facility":65,"status":32,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":66,"geoPoint":68,"contacts":32},"University of Texas Health Science Center at San Antonio",{"type":55,"coordinates":67},[57,58],{"lat":58,"lon":57},{"type":36,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Michael McGinity","Associate Professor",[73],{"name":74,"class":75},"Parasym Ltd.","INDUSTRY","100632160","modulating-inflammation-in-neuro-trauma-100632160",false,"NCT07510074","Modulating Inflammation in Neuro-Trauma","MINT: Modulating Inflammation in Neuro-Trauma","MINT","Inclusion Criteria:\n\n* Age 18-75 years old\n* Glasgow Coma Scale (GCS) Score 3-12\n* Expected Intensive Care Unit (ICU) stay \\> 48 hours\n* Presenting with acute Traumatic Brain Injury (TBI) within 24 hours\n\nExclusion Criteria:\n\n* Pregnant\n* Any electrical implanted device\n* Immunomodulatory medication\n* Human Immune Deficiency Virus (HIV) patients\n* Autoimmune disease\n* Known cancer immunotherapy\n* Past medical history of symptomatic bradycardia\n* Penetrating brain injury\n* Clinical team assessment of prognosis and imminent risk of death such as Decision to withdraw life-sustaining measures\n* Current incarceration\n* Trauma\u002FLaceration to the left ear","ALL","18 Years","75 Years",{"count":88,"type":89},16,"ESTIMATED","INTERVENTIONAL",[92],"NA","MINT is a single-site, prospective, randomized, double-blind, sham-controlled pilot trial evaluating the safety and feasibility of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with moderate to severe traumatic brain injury (GCS 3-12). Participants will be randomized to receive either active taVNS or sham stimulation using the same device. The primary objective is to assess the safety and feasibility of taVNS implementation in the acute TBI setting. Secondary objectives include exploratory measurement of serum inflammatory and neuronal injury biomarkers and assessment of functional outcome using the Extended Glasgow Outcome Scale at hospital discharge.",[95],"Traumatic Brain Injury",[97,98,99],"Vagus nerve stimulation (VNS)","Inflammation","Cerebral edema","NOT_YET_RECRUITING","2026-07-15",{"date":103,"type":104},"2026-07-17","ACTUAL",{"date":106,"type":89},"2026-08",{"date":108,"type":89},"2027-03",{"name":5,"class":6},2]