[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100288024":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":27,"studyPopulation":28,"armGroups":23,"interventions":23,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":60,"collaborators":63,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":23,"eligibilityCriteria":72,"healthyVolunteers":69,"sex":73,"minAge":74,"maxAge":23,"enrollmentInfo":75,"targetDuration":23,"studyType":78,"phases":23,"briefSummary":79,"conditions":80,"keywords":23,"overallStatus":46,"whyStopped":23,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Survival among patients at different stages of lung cancer and treatment will be measured using questionnaires along with medical chart data to monitor treatment and disease progression","Study lung cancer development in a case control study. We will look at three separate outcome measures specified below","20 years",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Overall survival","Measurement from time of diagnosis to death will be obtained",{"measure":18,"description":19,"timeFrame":12},"Progression-free survival","Time of diagnosis to disease progression (measured by metastasis)",{"measure":21,"description":22,"timeFrame":12},"Treatment toxicities","Effects on ECOG and physical sequelae from treatment (radiation, chemotherapy and other treatment modalities will be analyzed)",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":25,"timePerspective":26,"maskingInfo":23},"CASE_ONLY","PROSPECTIVE","Investigators also investigate how genetic variants may affect cancer treatment, at various stages of disease development, in order to determine prognostic and predictive factors for survival.","Lung cancer cases are recruited from Massachusetts General Hospital patient population. Cases come from Thoracic Surgery or Cancer Center. Healthy controls are no longer recruited.",[30],{"name":31,"affiliation":32,"role":33},"David C Christiani, MD","Harvard TH Chan School of Public Health","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":23,"email":39},"David Christiani, MD","CONTACT","617-726-9274","dchris@hsph.harvard.edu",{"name":41,"role":37,"phone":42,"phoneExt":23,"email":43},"Andrea Shafer, MPH","6177269274","ashafer@mgh.harvard.edu",[45],{"facility":5,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-71.05977,42.35843,{"lat":56,"lon":55},[59],{"name":41,"role":37,"phone":42,"phoneExt":23,"email":23},{"type":33,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"David Christopher Christiani","Elkan Blout Professor at Harvard TH Chan School of Public Health, Professor of Medicine Harvard Medical School",[64],{"name":65,"class":66},"National Cancer Institute (NCI)","NIH","100288024","molecular-and-genetic-analysis-of-lung-cancer-100288024",false,"NCT03029325","Boston Lung Cancer Study (Molecular and Genetic Analysis of Lung Cancer)","Inclusion Criteria:\n\n-cases: pathology proven primary lung cancer\n\nExclusion Criteria:\n\n* younger than 18 years old","ALL","18 Years",{"count":76,"type":77},15000,"ESTIMATED","OBSERVATIONAL","Investigators use a genome-wide approach within a case-control design to identify SNPs that show evidence of association with lung cancer risk and survival.",[81],"Lung Cancer","2026-10-05",{"date":84,"type":85},"2026-10-07","ACTUAL",{"date":87,"type":23},"1993-06",{"date":89,"type":77},"2028-09",{"name":5,"class":6},1]