[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659870":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":26,"studyPopulation":27,"armGroups":28,"interventions":33,"overallOfficials":23,"centralContacts":38,"locations":45,"responsibleParty":62,"collaborators":23,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":23,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":23,"enrollmentInfo":73,"targetDuration":23,"studyType":76,"phases":23,"briefSummary":77,"conditions":78,"keywords":23,"overallStatus":80,"whyStopped":23,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Nice","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Presence of at least one documented morbid event or manifestation","Binary outcome (yes\u002Fno): presence of at least one morbid event or manifestation documented in HYBRID-DF during available follow-up, including relevant bone, neurological, surgical, malignant, endocrine or other recorded morbidity.","Up to 10 years",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Nature of documented morbid events or manifestations","Nature of events\u002Fmanifestations, number of events per patient, time to event when a date is available, and recurrence\u002Fprogression when recorded.",{"measure":18,"description":19,"timeFrame":12},"Burden of documented morbid events or manifestations","Burden of events\u002Fmanifestations, number of events per patient, time to event when a date is available, and recurrence\u002Fprogression when recorded.",{"measure":21,"description":22,"timeFrame":12},"Disease management","Type and duration of bone-targeted and\u002For surgical treatments",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":6,"timePerspective":25,"maskingInfo":23},"RETROSPECTIVE","CRANIO-DF is a national, multicenter, retrospective observational study based exclusively on secondary use of data already collected in HYBRID-DF. Adults with fibrous dysplasia and documented craniofacial involvement will be included. No additional data will be collected from medical records. The study will describe disease characteristics, associated manifestations, bone-targeted treatments, fractures, neurological compressions, deformities, surgical procedures, malignant transformation, endocrine events and digestive\u002Fhepatobiliary-pancreatic abnormalities when available. The primary objective is to estimate the frequency of patients with at least one documented morbid event or manifestation during follow-up. Secondary objectives are to characterize these events, describe medical and surgical management, and explore factors associated with morbidity.","Adults with fibrous dysplasia and documented craniofacial involvement recorded in the French national EasyHYBRID-DF database, including monostotic craniofacial disease and polyostotic disease involving the craniofacial skeleton.",[29],{"label":30,"type":23,"description":23,"interventionNames":31},"Craniofacial fibrous dysplasia",[32],"Other: No Intervention: Observational Cohort",[34],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":23},"No Intervention: Observational Cohort","No Intervention",[30],[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Marie-Charlotte TROJANI","CONTACT","0492035499","+33","marie-charlotte.trojani@univ-cotedazur.fr",[46],{"facility":47,"status":23,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"CHU de Nice","Nice","Alpes Maritimes","06000","France","FR",{"type":54,"coordinates":55},"Point",[56,57],7.26608,43.70313,{"lat":57,"lon":56},[60,61],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},{"name":40,"role":41,"phone":23,"phoneExt":43,"email":44},{"type":63,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100659870","morbidity-in-adults-with-craniofacial-fibrous-dysplasia-the-cranio-df-study-100659870",false,"NCT07870616","Morbidity in Adults With Craniofacial Fibrous Dysplasia: The CRANIO-DF Study","Morbidity, Management, and Outcomes in Adults With Craniofacial Fibrous Dysplasia: A National Multicenter Retrospective Study Using the EasyHYBRID-DF Database","Inclusion Criteria:\n\n* Age 18 years or older\n* Diagnosis of fibrous dysplasia recorded in HYBRID-DF\n* Craniofacial involvement recorded in HYBRID-DF\n* No objection to reuse of data for research\n\nExclusion Criteria:\n\n* Erroneous diagnosis of fibrous dysplasia recorded in HYBRID-DF\n* Available data do not allow craniofacial involvement to be established","ALL","18 Years",{"count":74,"type":75},500,"ESTIMATED","OBSERVATIONAL","Fibrous dysplasia is a rare bone disorder in which normal bone is replaced by fibro-osseous tissue. Craniofacial involvement may be associated with substantial morbidity and complex multidisciplinary care. CRANIO-DF aims to describe morbidity, management and outcomes in adults with craniofacial fibrous dysplasia using the French national EasyHYBRID-DF database.",[79],"Craniofacial Fibrous Dysplasia","NOT_YET_RECRUITING","2026-10-06",{"date":83,"type":84},"2026-10-13","ACTUAL",{"date":86,"type":75},"2026-12-01",{"date":88,"type":75},"2028-12-01",{"name":5,"class":6},1]