[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647260":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":33,"centralContacts":63,"locations":72,"responsibleParty":86,"collaborators":33,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":99,"minAge":100,"maxAge":33,"enrollmentInfo":101,"targetDuration":33,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":33,"overallStatus":75,"whyStopped":33,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"University of Erlangen-Nürnberg Medical School","OTHER",[8,17,24],{"label":9,"type":6,"description":10,"interventionNames":11},"Control Group","Healthy individuals with no previous cancer diagnosis. Volunteers will receive physical examination, standardized pulmonary function testing including spirometry and assessment of the diffusing capacity of the lung for carbon monoxide (DLCO) using a single-breath technique and MRI on a low field system (Lung and heart). Furthermore, cardiopulmonary testing (spiroergometry and echocardiography) is performed.",[12,13,14,15,16],"Diagnostic Test: Spirometry","Diagnostic Test: DLCO measurement","Diagnostic Test: Echocardioraphy","Diagnostic Test: MRI","Other: Clinical parameters",{"label":18,"type":6,"description":19,"interventionNames":20},"Survivors of leukemia","Survivors of treatment for acute lymphatic leukemia in childhood or adolescence. Participants will receive physical examination, standardized pulmonary function testing including spirometry and assessment of the diffusing capacity of the lung for carbon monoxide (DLCO) using a single-breath technique and MRI on a low field system (Lung and heart). Furthermore, cardiopulmonary testing (spiroergometry and echocardiography) and multispectral optoacoustic tomography (MSOT) for Peripheral artery disease (PAD) are performed. compliant data storage). In addition, venous blood samples will be taken for the analysis of molecular biomarkers.",[21,12,13,14,15,16,22,23],"Other: QOL assessment, Neuropsychological","Diagnostic Test: Blood samples","Diagnostic Test: MSOT",{"label":25,"type":6,"description":26,"interventionNames":27},"Survivors of lymphoma","Survivors of treatment for lymphoma in childhood or adolescence. Participants will receive physical examination, standardized pulmonary function testing including spirometry and assessment of the diffusing capacity of the lung for carbon monoxide (DLCO) using a single-breath technique and MRI on a low field system (Lung and heart). Furthermore, cardiopulmonary testing (spiroergometry and echocardiography) and multispectral optoacoustic tomography (MSOT) for Peripheral artery disease (PAD) are performed. compliant data storage). In addition, venous blood samples will be taken for the analysis of molecular biomarkers.",[21,12,13,14,15,16,22,23],[29,34,39,43,47,51,55,59],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"QOL assessment, Neuropsychological","QoL assessment by EORTC SURV100, PPR",[18,25],null,{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":33},"DIAGNOSTIC_TEST","Spirometry","During this non-invasive test, the subject must breathe against resistance through a mouthpiece.",[9,18,25],{"type":35,"name":40,"description":41,"armGroupLabels":42,"otherNames":33},"DLCO measurement","DLCO measurement is a non-invasive pulmonary function test for Pulmonary Diffusion Capacity.",[9,18,25],{"type":35,"name":44,"description":45,"armGroupLabels":46,"otherNames":33},"Echocardioraphy","Echocardiography with strain-rate imaging.",[9,18,25],{"type":35,"name":48,"description":49,"armGroupLabels":50,"otherNames":33},"MRI","LF-MRI for detection of morphological and functional changes in the lung and heart.",[9,18,25],{"type":6,"name":52,"description":53,"armGroupLabels":54,"otherNames":33},"Clinical parameters","Recording patient information (Age, Gender, Weight and height, Ethnicity, current medication, measurement of blood pressure and blood oxygen saturation.",[9,18,25],{"type":35,"name":56,"description":57,"armGroupLabels":58,"otherNames":33},"Blood samples","Blood samples for further molecular testing regarding epigenetic aging markers and telomere biology parameters.",[18,25],{"type":35,"name":60,"description":61,"armGroupLabels":62,"otherNames":33},"MSOT","multispectral optoacoustic tomography of musculus gastrocnemius bilaterally for screening of PAD",[18,25],[64,69],{"name":65,"role":66,"phone":67,"phoneExt":33,"email":68},"Axel Karow, PD. Dr. med.","CONTACT","09131 8533118","axel.karow@uk-erlangen.de",{"name":70,"role":66,"phone":67,"phoneExt":33,"email":71},"Ferdinand Knieling, Prof. Dr. med.","ferdinand.knieling@uk-erlangen.de",[73],{"facility":74,"status":75,"city":76,"state":33,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":85,"contacts":33},"Department of Pediatrics and Adolescent Medicine","RECRUITING","Erlangen","91054","Germany","DE",{"type":81,"coordinates":82},"Point",[83,84],11.00783,49.59099,{"lat":84,"lon":83},{"type":87,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Ferdinand Knieling","Prof. Dr. med. Dr. rer. biol. hum. Ferdinand Knieling MHBA","100647260","more-than-just-x-rays---imaging-of-chemotherapy-induced-morphological-and-functional-cardiovascular-and-lung-changes-after-childhood-all-and-other-cancers---a-monocentric-late-effects-study-maximall-100647260",false,"NCT07705178","More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)","\"MaximALL\" More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)","MaximALL","Control Group:\n\nInclusion Criteria:\n\n* no cancer diagnosis\n* no lung diseases\n* no vascular diseases\n* No subjective reduction in physical performance\n* age \\>\u002F= 18 years\n\nExclusion Criteria:\n\n* Pregnancy, Lactation\n* Known pleural or pericardial effusion\n* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)\n* Marked thoracic deformities\u002Fmalformations\n* Previous lung surgery\n* Injuries that do not allow physical stress diagnostics\n* Rejection of MRI imaging\n* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)\n\nSurvivors of ALL:\n\nInclusion Criteria:\n\n* Completed therapy for ALL\n* age \\>\u002F= 3 years\n\nExclusion Criteria:\n\n* Pregnancy, Lactation\n* Known pleural or pericardial effusion\n* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)\n* Marked thoracic deformities\u002Fmalformations\n* Previous lung surgery\n* Injuries that do not allow physical stress diagnostics\n* Rejection of MRI imaging\n* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)\n\nSurvivors of Lymphoma:\n\nInclusion Criteria:\n\n* Completed therapy for lymphoma\n* age \\>\u002F= 3 years\n\nExclusion Criteria:\n\n* Pregnancy, Lactation\n* Known pleural or pericardial effusion\n* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)\n* Marked thoracic deformities\u002Fmalformations\n* Previous lung surgery\n* Injuries that do not allow physical stress diagnostics\n* Rejection of MRI imaging\n* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)",true,"ALL","3 Years",{"count":102,"type":103},180,"ESTIMATED","INTERVENTIONAL",[106],"NA","In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.",[109,110],"Acute Lymphatic Leukemia","Lymphoma","2026-07-09",{"date":113,"type":114},"2026-07-15","ACTUAL",{"date":116,"type":103},"2026-07-14",{"date":118,"type":103},"2028-10-31",{"name":5,"class":6},1]