[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657047":3},{"organization":4,"outcomesModule":7,"designInfo":84,"detailedDescription":92,"studyPopulation":83,"armGroups":93,"interventions":112,"overallOfficials":83,"centralContacts":125,"locations":131,"responsibleParty":148,"collaborators":83,"id":150,"slug":151,"hasResults":152,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":83,"eligibilityCriteria":155,"healthyVolunteers":156,"sex":157,"minAge":158,"maxAge":159,"enrollmentInfo":160,"targetDuration":83,"studyType":163,"phases":164,"briefSummary":166,"conditions":167,"keywords":169,"overallStatus":133,"whyStopped":83,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":185},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":60,"otherOutcomes":83},[9,13,15,17,19,21,25,28,31,34,37,40,43,46,49,53,56],{"measure":10,"description":11,"timeFrame":12},"EEG delta band (0.5-4 Hz) absolute power","Raw EEG data were collected via Smarting Pro during functional assessments.","Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.",{"measure":14,"description":11,"timeFrame":12},"EEG theta band (4-8 Hz) absolute power",{"measure":16,"description":11,"timeFrame":12},"EEG alpha band (8-13 Hz) absolute power",{"measure":18,"description":11,"timeFrame":12},"EEG beta band (13-30 Hz) absolute power",{"measure":20,"description":11,"timeFrame":12},"EEG gamma band (30-50 Hz) absolute power",{"measure":22,"description":23,"timeFrame":24},"Vicon 3D Gait Analysis-Spatiotemporal parameters-Gait Speed","Gait speed recorded during walking using Vicon 3D gait analysis.Unit of Measure: m\u002Fs","Part 1: cross-sectional assessment at 12 months after ACL reconstruction. Part 2: longitudinal study evaluating patients at preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.",{"measure":26,"description":27,"timeFrame":24},"Vicon 3D Gait Analysis-Spatiotemporal parameters-Step Length","Step length recorded during walking using Vicon 3D gait analysis.Unit of Measure: m",{"measure":29,"description":30,"timeFrame":24},"Vicon 3D Gait Analysis-Spatiotemporal parameters-Cadence","Cadence recorded during walking using Vicon 3D gait analysis.Unit of Measure: steps\u002Fmin",{"measure":32,"description":33,"timeFrame":12},"Vicon 3D Gait Analysis-Peak Knee Flexion Angle","Peak knee flexion angle during walking measured using Vicon 3D gait analysis. Unit of Measure: degrees",{"measure":35,"description":36,"timeFrame":12},"Vicon 3D Gait Analysis-Peak Knee Extension Angle","Peak knee extension angle during walking measured using Vicon 3D gait analysis.Unit of Measure: degrees",{"measure":38,"description":39,"timeFrame":12},"Vicon 3D Gait Analysis-Peak Knee Abduction Angle","Peak knee abduction angle during walking measured using Vicon 3D gait analysis.Unit of Measure: degrees",{"measure":41,"description":42,"timeFrame":12},"Vicon 3D Gait Analysis-Peak Knee Adduction Angle","Peak knee adduction angle during walking measured using Vicon 3D gait analysis.Unit of Measure: degrees",{"measure":44,"description":45,"timeFrame":12},"Vicon 3D Gait Analysis-Ground Reaction Force - Peak at Initial Contact","Peak vertical ground reaction force at initial contact during walking measured using Vicon 3D gait analysis.Unit of Measure: N\u002Fkg",{"measure":47,"description":48,"timeFrame":12},"Vicon 3D Gait Analysis-Peak Knee Flexion Moment","Peak external knee flexion moment during walking measured using Vicon 3D gait analysis.Unit of Measure: Nm\u002Fkg",{"measure":50,"description":51,"timeFrame":52},"Electromyography (EMG) testing -Frequency-Domain","Surface electromyography (sEMG) signals were collected from the lower extremity muscles during the Vicon 3D gait analysis to extract frequency-domain features for muscle fatigue assessment.","Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively",{"measure":54,"description":55,"timeFrame":52},"Electromyography (EMG) testing -Time-Domain","Surface electromyography (sEMG) signals were collected from the lower extremity muscles during the Vicon 3D gait analysis to extract time-domain features quantifying muscle activation levels.",{"measure":57,"description":58,"timeFrame":59},"Functional Magnetic Resonance Imaging (fMRI) testing","A subset of participants underwent task-based fMRI to identify cortical activation patterns during motor imagery.","Part 2 includes longitudinal neuroimaging assessments. Resting-state functional magnetic resonance imaging (rs-fMRI) will be performed at preoperative baseline,6 month , and 12 months postoperatively to investigate changes in sensorimotor network conne",[61,65,68,71,74,77,80],{"measure":62,"description":63,"timeFrame":64},"Isokinetic muscle strength testing","Isokinetic peak torque of the quadriceps and hamstrings was measured to evaluate muscle strength symmetry between the injured and uninjured limbs.","For Part 2, assessments will be conducted at 6 and 12 months postoperatively.",{"measure":66,"description":67,"timeFrame":12},"Mental chronometry","Mental chronometry was assessed to compare the imagined duration of movement with the actual execution time.",{"measure":69,"description":70,"timeFrame":12},"Kinesthetic and Visual Imagery Questionnaire-20","The KVIQ-20 assesses subjective kinesthetic (body sensations) and visual (mental pictures) imagery abilities related to leg movements. The questionnaire consists of 20 items divided into two dimensions: Kinesthetic and Visual. Each item is rated on a 6-point Likert scale from 0 to 5 based on the clarity and richness of the imagery experienced. The total score ranges from 0 to 100. A higher score indicates greater imagery ability, meaning the patient can more vividly see the movement and feel the muscle\u002Fjoint activity in their mind.",{"measure":72,"description":73,"timeFrame":12},"Tegner Activity Scale","used to assess patients' level of physical activity and participation in sports. This scale ranges from 0 to 10, with higher scores indicating higher activity levels. A score of 0 represents disability due to knee problems (sick leave), while a score of 10 represents participation in competitive sports such as soccer or rugby at a national elite level. The scale captures both work and recreational activities, providing a comprehensive measure of functional activity beyond simple symptom relief.",{"measure":75,"description":76,"timeFrame":12},"Visual Analogue Score, VAS","The Visual Analogue Scale (VAS) was used to assess patients' pain intensity at rest or during activity. The scale is typically represented as a 10 cm horizontal line, with \"No pain\" at one end and \"Worst imaginable pain\" at the other. Patients mark a point on the line corresponding to their perceived pain level, and the distance from the start is measured as the score.",{"measure":78,"description":79,"timeFrame":12},"International Knee Documentation Committee, IKDC","The IKDC Subjective Knee Form was used to evaluate symptoms (pain, stiffness, swelling, locking\u002Fgiving way) and functional limitations related to sports and daily activities following ACL reconstruction, as well as current knee function relative to pre-injury status. A normalized total score is calculated from these domains.\n\nScoring Interpretation Minimum Value: Approximately 0 points (representing severe symptoms or complete loss of function) Maximum Value: 100 points (representing no symptoms and fully normal function) Does a higher score mean a better outcome?: Yes. A higher score indicates fewer knee symptoms and better motor function and daily activity performance.",{"measure":81,"description":82,"timeFrame":12},"Tampa Scale for Kinesiophobia-11 (TSK-11)","Kinesiophobia was assessed using the Tampa Scale for Kinesiophobia-11 (TSK-11). The TSK-11 is an 11-item self-report questionnaire measuring fear of movement and re-injury, rated on a 4-point Likert scale (1 = strongly disagree to 4 = strongly agree). Total scores range from 11 to 44, with higher scores indicating greater kinesiophobia. Scores reflect the severity of fear; therefore, a higher score represents a worse outcome (indicating greater fear).",null,{"allocation":85,"interventionModel":86,"interventionModelDescription":83,"primaryPurpose":87,"observationalModel":83,"timePerspective":83,"maskingInfo":88},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":89,"maskingDescription":83,"whoMasked":90},"SINGLE",[91],"PARTICIPANT","Part 1 employs a cross-sectional design, comparing patients one year after anterior cruciate ligament reconstruction (ACLR) (experimental group) with healthy adults (control group). This phase aims to acquire electroencephalography (EEG) and lower limb functional data across different states to elucidate the correlation between cortical function and motor behavior.\n\nPart 2 will conduct a 12-week randomized controlled trial (RCT). ACL rupture patients will be allocated to either a motor imagery intervention group or a conventional rehabilitation control group. We will integrate EEG and kinematic analysis to systematically evaluate the therapy's effects on knee function, neuromuscular control, and brain network connectivity. Furthermore, by combining longitudinal EEG and resting-state functional magnetic resonance imaging (rs-fMRI), we will investigate the underlying neuroplastic mechanisms driving functional remodeling within the sensorimotor networks. This research is expected to establish a novel, active intervention strategy based on the \"central-driven peripheral\" paradigm for ACL postoperative rehabilitation.",[94,98,100,106],{"label":95,"type":96,"description":97,"interventionNames":83},"healthy adults (control group)","NO_INTERVENTION","aims to acquire electroencephalography (EEG) and lower limb functional data across different states to elucidate the correlation between cortical function and motor behavior.",{"label":99,"type":96,"description":97,"interventionNames":83},"patients one year after anterior cruciate ligament reconstruction (ACLR) (experimental group)",{"label":101,"type":102,"description":103,"interventionNames":104},"Motor Imagery Therapy group","EXPERIMENTAL","Conventional rehabilitation augmented with motor imagery training.",[105],"Behavioral: Motor Imagery Therapy (i.e., \"mentally practicing movement\")",{"label":107,"type":108,"description":109,"interventionNames":110},"control group","ACTIVE_COMPARATOR","receiving standard rehabilitation as the control group.",[111],"Behavioral: conventional rehabilitation\"",[113,121],{"type":114,"name":115,"description":116,"armGroupLabels":117,"otherNames":118},"BEHAVIORAL","Motor Imagery Therapy (i.e., \"mentally practicing movement\")","Part 2 will conduct a 12-week RCT. The experimental group will receive conventional rehabilitation augmented with motor imagery training. This training will be delivered via a hybrid model (in-person and online) and consist primarily of video-guided imagery sessions.",[101],[119,120],"Motor Simulation","Video-Guided Motor Imagery",{"type":114,"name":122,"description":123,"armGroupLabels":124,"otherNames":83},"conventional rehabilitation\"","The control group received conventional rehabilitation only. During in-person sessions, they engaged in passive observation of static photographs, without any form of active mental simulation or motor rehearsal. During remote sessions, they watched the same videos as the experimental group but proceeded directly to physical practice without prior motor imagery.",[107],[126],{"name":127,"role":128,"phone":129,"phoneExt":83,"email":130},"XIAOYUAN HAN, GRADUATE STUDENT","CONTACT","18522596808","15522650818@163.com",[132],{"facility":5,"status":133,"city":134,"state":135,"zip":136,"country":137,"countryCode":138,"cosmosGeoPoint":139,"geoPoint":144,"contacts":145},"RECRUITING","Beijing","Beijing Municipality","100191","China","CN",{"type":140,"coordinates":141},"Point",[142,143],116.39723,39.9075,{"lat":143,"lon":142},[146],{"name":147,"role":128,"phone":129,"phoneExt":83,"email":130},"Han",{"type":149,"investigatorFullName":83,"investigatorTitle":83,"investigatorAffiliation":83,"oldNameTitle":83,"oldOrganization":83},"SPONSOR","100657047","motor-imagery-enhanced-rehabilitation-modulates-cortical-plasticity-and-functional-recovery-after-acl-reconstruction-100657047",false,"NCT07833189","Motor Imagery-Enhanced Rehabilitation Modulates Cortical Plasticity and Functional Recovery After ACL Reconstruction","Part 1: Participants\n\nStudy Design:\n\n* This study will recruit 20 patients at 12 months after ACL reconstruction and 20 healthy controls.\n* Age range: 18-45 years.\n\nInclusion Criteria for Patient Group:\n\n* Age: 18-45 years old.\n* Body Mass Index (BMI): ≥18.5 kg\u002Fm² and \\\u003C35 kg\u002Fm².\n* Injury Type: First-time unilateral isolated ACL rupture, reconstructed at our hospital.\n* Surgical Technique: Single-bundle hamstring tendon autograft transplantation.\n* Ligament Stability: No injury or only mild injury (Grade I) to the PCL, MCL, or LCL.\n* Postoperative Timeline: 12 months after ACL reconstruction.\n* Consent: Voluntary participation with signed informed consent.\n\nExclusion Criteria for Patient Group:\n\n* Delayed Surgery: ACL reconstruction performed \\>6 months after injury.\n* Combined Injuries: Severe injury (\\>Grade I) to PCL, MCL, or LCL; severe meniscus tear.\n* Previous Surgery: History of lower limb knee surgery (e.g., meniscus repair, arthroplasty).\n* Comorbidities: Existing knee diseases (e.g., osteoarthritis, tumors, rheumatoid arthritis, fracture).\n* Systemic\u002FCognitive Issues: Severe cardiac, pulmonary, cerebral disease, or hepatic\u002Frenal dysfunction; visual or cognitive impairment.\n* Imagery Ability: Score \\\u003C55 on the KVIQ-20.\n\nInclusion Criteria for Healthy Controls:\n\n* Age: 18-45 years old.\n* Body Mass Index (BMI): ≥18.5 kg\u002Fm² and \\\u003C35 kg\u002Fm².\n* Medical History: No history of surgery, injury, or chronic lower limb joint disease.\n* Neurological Status: No visual\u002Fcognitive impairment or neurological disorders.\n* Gait: No trauma or disease causing gait abnormalities.\n* Consent: Voluntary participation with signed informed consent.\n* Imagery Ability: Score \\\u003C55 on the KVIQ-20. Study 2: Participants\n\nStudy Design:\n\n* This study aims to recruit 40 patients meeting the specified criteria.\n* Randomization: Participants will be randomly allocated into an experimental group (N=20) and a control group (N=20).\n\nInclusion Criteria for Patients:\n\n* Age: 18-45 years old.\n* Body Mass Index (BMI): ≥18.5 kg\u002Fm² and \\\u003C35 kg\u002Fm².\n* Injury Type: First-time unilateral isolated ACL rupture, reconstructed at our hospital.\n* Surgical Technique: Single-bundle hamstring tendon autograft transplantation.\n* Ligament Stability: No injury or only mild injury (Grade I) to the PCL, MCL, or LCL.\n* Consent: Voluntary participation with signed informed consent.\n* Exclusion Criteria for Patients:\n* Delayed Surgery: ACL reconstruction performed \\>6 months after injury.\n* Combined Injuries: Severe injury (\\>Grade I) to PCL, MCL, or LCL (Grade II-III); severe meniscus tear.\n* Previous Surgery: History of lower limb knee surgery (e.g., meniscus repair, ligament reconstruction, arthroplasty).\n* Comorbidities: Existing knee diseases (e.g., osteoarthritis, tumors, rheumatoid arthritis, tuberculosis, infection).\n* Systemic\u002FCognitive Issues: Severe cardiac, pulmonary, cerebral disease, or hepatic\u002Frenal dysfunction; visual or cognitive impairment.\n* Imagery Ability: Score \\\u003C55 on the KVIQ-20.",true,"ALL","18 Years","45 Years",{"count":161,"type":162},80,"ESTIMATED","INTERVENTIONAL",[165],"NA","Part 1: Neural Correlates of Motor Imagery in ACLR Patients This cross-sectional study aims to systematically compare differences in electroencephalographic (EEG) activity between patients who have returned to sport one year after anterior cruciate ligament reconstruction (ACLR) and healthy controls during functional tasks and associated motor imagery. We will collect EEG activity and behavioral performance data from both groups during task execution and imagination. The primary objective is to verify whether ACLR patients exhibit a specific deficit in motor imagery capability and to characterize the abnormal functional patterns within their central sensorimotor networks. By providing an objective, neurophysiological explanation for why patients struggle to return to sport, this study seeks to establish quantifiable baseline metrics for subsequent interventional research.\n\nPart 2: Effects and Cortical Plasticity Changes Following Motor Imagery-Enhanced Rehabilitation This randomized controlled trial (RCT) combines short-term intervention with long-term follow-up to systematically evaluate the efficacy and mechanisms of motor imagery therapy in ACLR patients. The specific objectives are threefold: First, to verify the immediate effects of the intervention on enhancing neuroplasticity and restoring motor function. Second, to assess the long-term impact on definitive clinical outcomes-specifically return-to-sport rates and time to return-through a 12-month follow-up. Third, to perform a longitudinal analysis determining whether early improvements in neurophysiological indicators can predict subsequent gains in motor performance and successful return-to-sport outcomes.",[168],"ACL Injury",[170,171,172,173,174,175],"ACLR","EEG","Motor Imagery","Rehabilitation","ACL","Neuromuscular Biomechanics","2026-09-20",{"date":178,"type":179},"2026-09-22","ACTUAL",{"date":181,"type":179},"2026-06-15",{"date":183,"type":162},"2027-08-10",{"name":5,"class":6},1]