[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655020":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":17,"armGroups":18,"interventions":23,"overallOfficials":27,"centralContacts":31,"locations":42,"responsibleParty":309,"collaborators":13,"id":311,"slug":312,"hasResults":313,"nctId":314,"briefTitle":315,"officialTitle":315,"acronym":13,"eligibilityCriteria":316,"healthyVolunteers":313,"sex":317,"minAge":318,"maxAge":13,"enrollmentInfo":319,"targetDuration":322,"studyType":323,"phases":13,"briefSummary":324,"conditions":325,"keywords":13,"overallStatus":45,"whyStopped":13,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":339},{"fullName":5,"class":6},"Second Affiliated Hospital of Soochow University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Natural disease progression of various atypical parkinsonian syndromes","To observe the differences in the natural disease progression of various atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rates of motor and non-motor symptoms and the patterns of imaging evolution. The preliminary study design involves a follow-up period of 3 years, with assessments of clinical phenotypes and\u002For biomarker changes every 6 months.","up to 36 months",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","Patients diagnosed with multiple system atrophy (MSA) , dementia with Lewy bodies (DLB) , progressive supranuclear palsy (PSP) , or corticobasal degeneration (CBD) according to Chinese\u002Finternational consensus diagnostic criteria . Follow-up period : 3 years , with clinical phenotypes and\u002For biomarkers assessed every 6 months .",[19],{"label":20,"type":13,"description":13,"interventionNames":21},"Atypical parkinsonian syndromes",[22],"Other: We did not apply any interventions; only observational research was conducted.",[24],{"type":6,"name":25,"description":25,"armGroupLabels":26,"otherNames":13},"We did not apply any interventions; only observational research was conducted.",[20],[28],{"name":29,"affiliation":5,"role":30},"Chunfeng Liu","STUDY_CHAIR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":13,"email":36},"Jinru Zhang, PhD. MD.","CONTACT","+8615850210657","zhangjinruruby@126.com",{"name":38,"role":34,"phone":39,"phoneExt":40,"email":41},"Chunfeng Liu, PhD. 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Wang","+8613486331646",{"facility":267,"status":64,"city":268,"state":13,"zip":13,"country":49,"countryCode":50,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Deyang People's Hospital","Deyang",{"type":52,"coordinates":270},[271,272],104.38198,31.13019,{"lat":272,"lon":271},[275],{"name":276,"role":34,"phone":277,"phoneExt":13,"email":13},"Ping Zhang","+8615883850268",{"facility":279,"status":64,"city":280,"state":13,"zip":13,"country":49,"countryCode":50,"cosmosGeoPoint":281,"geoPoint":285,"contacts":286},"Changxing people' s hospital","Huzhou",{"type":52,"coordinates":282},[283,284],120.0933,30.8703,{"lat":284,"lon":283},[287],{"name":288,"role":34,"phone":289,"phoneExt":13,"email":13},"Donghui Li","+8615067223301",{"facility":291,"status":64,"city":106,"state":13,"zip":13,"country":49,"countryCode":50,"cosmosGeoPoint":292,"geoPoint":294,"contacts":295},"Affiliated Hospital of Nantong University",{"type":52,"coordinates":293},[110,111],{"lat":111,"lon":110},[296],{"name":297,"role":34,"phone":298,"phoneExt":13,"email":13},"Xiaosu Gu","13962998759",{"facility":300,"status":64,"city":156,"state":13,"zip":13,"country":49,"countryCode":50,"cosmosGeoPoint":301,"geoPoint":303,"contacts":304},"The Affiliated Hospital of Xuzhou Medical University",{"type":52,"coordinates":302},[160,161],{"lat":161,"lon":160},[305],{"name":306,"role":34,"phone":307,"phoneExt":13,"email":308},"Liguo Dong","+8618795425932","dongliguo@xzhmu.edu.cn",{"type":310,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100655020","multi-center-study-of-natural-history-in-atypical-parkinsonian-syndromes-maps-nh-100655020",false,"NCT07805967","Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)","Inclusion Criteria:\n\n1. MSA : Meets the \"probable MSA\" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) .\n2. DLB : Meets \"probable DLB\" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) .\n3. PSP : Meets \"probable PSP-Richardson syndrome\" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years .\n4. CBD : Meets \"probable CBD\" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia\u002Fdystonia\u002Falien limb).\n\nExclusion Criteria:\n\n1. Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure .\n2. Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .","ALL","18 Years",{"count":320,"type":321},500,"ESTIMATED","3 Years","OBSERVATIONAL","This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.",[326,327,328,329],"Multiple System Atrophy","Dementia With Lewy Bodies (DLB)","Progressive Supranuclear Palsy (PSP)","Corticobasal Degeneration (CBD)","2026-09-01",{"date":332,"type":333},"2026-09-08","ACTUAL",{"date":335,"type":333},"2025-11-12",{"date":337,"type":321},"2030-08-31",{"name":5,"class":6},20]