[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652295":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":13,"centralContacts":18,"locations":10,"responsibleParty":28,"collaborators":30,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":43,"sex":44,"minAge":45,"maxAge":10,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"Healthy participants who do not have an inflammatory skin condition",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Participants with an inflammatory skin condition",[14],{"name":15,"affiliation":16,"role":17},"Su M Lwin, MRCP (Derm) PhD BSc (Hons)","King's College London","PRINCIPAL_INVESTIGATOR",[19,25],{"name":20,"role":21,"phone":22,"phoneExt":23,"email":24},"Project Manager","CONTACT","+44 20 7188 7188","53378","kate.1.widdows@kcl.ac.uk",{"name":26,"role":21,"phone":22,"phoneExt":23,"email":27},"Clinical Trial Manager","rashida.pramanik@nhs.net",{"type":29,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[31,33],{"name":32,"class":6},"LifeArc",{"name":34,"class":35},"DEBRA","UNKNOWN","100652295","multi-omic-signatures-of-inflammatory-cutaneous-diseases-100652295",false,"NCT07771673","Multi-Omic SignAtures of Inflammatory Cutaneous Diseases","MOSAIC","Inclusion Criteria:\n\n* Able to provide written informed consent prior to performing any protocol-related procedures, including screening.\n* Adults (≥18 years) with confirmed diagnosis of inflammatory skin disease (defined as any skin disease with an inflammatory component, including but not limited to, genetic skin disease, such as EB), OR\n* Adults age (≥18 years) without skin or systemic disease.\n\nExclusion Criteria:\n\n* Inability to give written informed consent.\n* Participants who have received topical corticosteroids to sites of biopsies (inflamed area of skin) for at least 2 weeks prior to tissue sampling.\n* Inability to participate in study-specific procedures.\n* Participants who are pregnant (confirmed on a positive urine pregnancy test) or breastfeeding\n* Enrolment in any interventional study with systemic treatment within 3 months prior to baseline biopsy.",true,"ALL","18 Years",{"count":47,"type":48},400,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to identify the immune profile underlying various inflammatory skin diseases, through multi-omic procedures.\n\nThe main questions it aims to answer are:\n\n1. What are the molecular and immune signatures of individuals with inflammatory skin disease?\n2. Can these signatures reveal potential therapeutic targets for individuals with inflammatory skin disease?\n3. How do patients' multi-omic signatures change before and after receiving systemic therapy?\n4. Can the samples and data collected through this study provide a valuable bioresource for future skin disease research?",[52],"Inflammatory Skin Conditions",[54,55,56,57,58,59],"Inflammatory skin disease","Epidermoylsis Bullosa","NanoString","Multiomics","Eczema","Psoriasis","NOT_YET_RECRUITING","2026-08-13",{"date":63,"type":64},"2026-08-18","ACTUAL",{"date":66,"type":48},"2026-09",{"date":68,"type":48},"2031-07",{"name":5,"class":6}]