[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649984":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":40,"collaborators":44,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":58,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":69,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Hubei Cancer Hospital","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Lung Cancer Patients Receiving Sequential Immunotherapy and Thoracic Radiotherapy",null,[12],"Other: No Intervention: Observational Cohort",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":10},"No Intervention: Observational Cohort","This study involves collection of peripheral blood, urine, and stool samples from lung cancer patients who have received immunotherapy followed by thoracic radiotherapy. Samples are obtained at baseline prior to the initiation of radiotherapy for comprehensive multi-omics profiling, including genomic, transcriptomic, proteomic, and metabolomic analyses. No therapeutic intervention is administered as part of this study.",[9],[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Guang Han","CONTACT","027-87671663","hg7913@hotmail.com",[25],{"facility":26,"status":10,"city":27,"state":28,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","Wuhan","Hubei","430079","China","CN",{"type":33,"coordinates":34},"Point",[35,36],114.26667,30.58333,{"lat":36,"lon":35},[39],{"name":20,"role":21,"phone":10,"phoneExt":10,"email":23},{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","HAN GUANG","Clinical Professor",[45],{"name":26,"class":6},"100649984","multi-omics-prediction-of-radiation-lung-injury-in-immunotherapy-treated-lung-cancer-patients-100649984",false,"NCT07742800","Multi-Omics Prediction of Radiation Lung Injury in Immunotherapy-Treated Lung Cancer Patients","Multi-Omics Prediction of Radiation Pneumonitis Risk in Lung Cancer Patients After Immunotherapy and Thoracic Radiotherapy","Inclusion Criteria:\n\nPatients aged 18 or older years with a life expectancy of at least 6 months. Additional inclusion criteria were a Zubrod performance status of 0-1, documentation of baseline chest computed tomography (CT) scans prior to the initiation of immunotherapy, receipt of at least 2 cycles of systemic therapy (PD-1) as either monotherapy or combination therapy within the past six months, voluntary participation with written informed consent, and appropriate baseline biochemical tests. The radiation dose for thoracic radiotherapy was ≥30Gy for all eligible patients in this study. No use of antibiotics within 1 week prior to the initiation of thoracic radiotherapy.\n\nExclusion Criteria:Participation in other interventional clinical studies or treatments, having received investigational drugs or treatments within 4 weeks prior to the first dose, or prior receipt of a solid organ or hematopoietic stem cell transplant, having an active infection, or pre-existing\u002Factive ICI-induced pneumonitis.\n\n\\-","ALL","18 Years",{"count":56,"type":57},160,"ESTIMATED","6 Months","OBSERVATIONAL","This prospective study aims to develop a multi-omics-based predictive model for radiation pneumonitis in lung cancer patients receiving sequential immunotherapy and thoracic radiotherapy.",[62,63],"Lung Cancer (NSCLC)","Lung Cancer (SCLC)",[65,66,67,68],"Radiation Pneumonitis","Multi-Omics","Immunotherapy","Predictive Biomarkers","NOT_YET_RECRUITING","2026-07-29",{"date":72,"type":73},"2026-08-03","ACTUAL",{"date":75,"type":57},"2026-08-15",{"date":77,"type":57},"2028-08-15",{"name":42,"class":6},1]