[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652497":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":20,"responsibleParty":27,"collaborators":20,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":20,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":20,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":50,"overallStatus":58,"whyStopped":20,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":20},{"fullName":5,"class":6},"Pamukkale University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Spinal Mobilization Group","EXPERIMENTAL","Participants receive a multi-segmental spinal manual therapy intervention targeting the cervical, thoracic, lumbar, and sacral regions. The protocol consists of 10 sessions conducted over a 2-week period (5 sessions per week, each lasting approximately 30 to 45 minutes). Treatment includes passive joint mobilizations (specifically Mulligan Concept techniques) applied across spinal segments and soft tissue mobilization techniques targeted specifically at the cervical region, tailored to baseline examination findings. No high-velocity low-amplitude (HVLA) thrust manipulations are administered.",[13],"Procedure: Multi-Segmental Spinal Manual Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Multi-Segmental Spinal Manual Therapy","The intervention protocol consists of 10 individual sessions delivered over 2 consecutive weeks (5 sessions per week, approximately 30 to 45 minutes per session).\n\nThe treatment includes two primary components:\n\n1. Multi-segmental Spinal Joint Mobilizations: Passive joint mobilization techniques (specifically Mulligan Concept techniques, such as Mobilization with Movement \\[MWM\\] and Natural Glides) applied to the cervical, thoracic, lumbar, and sacral regions based on baseline physical examination findings. High-velocity low-amplitude (HVLA) thrust manipulations are not performed.\n2. Cervical Soft Tissue Mobilization: Soft tissue mobilization and myofascial techniques targeted specifically to the cervical and suboccipital musculature.\n\nAll procedures are administered by a licensed physical therapist in a standardized clinical setting.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Borna FARHOOMAND, PT, MSc","CONTACT","05449033638","borna.farhoomand@gmail.com",{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"SPONSOR_INVESTIGATOR","Borna Farhoomand","Physiotherapist, MSc","100652497","multi-segmental-spinal-manual-therapy-in-women-with-episodic-migraine-100652497",false,"NCT07774286","Multi-Segmental Spinal Manual Therapy in Women With Episodic Migraine","Multi-segmental Spinal Manual Therapy for Pain, Central Sensitization, and Sensorimotor Control in Women With Episodic Migraine: A Case Series.","Inclusion Criteria:\n\n* Female patients aged 18-30 years,\n* Diagnosis of episodic migraine established by a specialist neurologist,\n* Headache frequency of \\\u003C15 days per month,\n* Pain intensity score of ≥40 mm on the Visual Analog Scale (VAS),\n* Absence of any diagnosed psychiatric disorders,\n* Literacy (ability to read and write),\n* Ability to communicate effectively without language or cognitive barriers,\n* Voluntary participation confirmed by signed written informed consent.\n\nExclusion Criteria:\n\n* History of communication disorders or neuromusculoskeletal diseases that impede assessment procedures,\n* Headache frequency exceeding 15 days per month,\n* Diagnosis of other primary or secondary headache types (e.g., cervicogenic headache, tension-type headache),\n* Pregnancy,\n* Diagnosis of fibromyalgia syndrome or myofascial pain syndrome,\n* Diagnosis of systemic rheumatic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus),\n* Diagnosis or presence of symptoms related to spinal disc disorders (e.g., disc herniation, disc prolapse),\n* History of whiplash or similar cervical\u002Fhead trauma,\n* Diagnosis or presence of symptoms associated with temporomandibular joint dysfunction (TMD),\n* Having received physical therapy within the last 3 months,\n* Having undergone anesthetic nerve block procedures within the last 6 months,\n* Receiving any prophylactic or interventional migraine therapy other than acute analgesics,\n* Self-reported history or presence of malignancy.","FEMALE","18 Years","30 Years",{"count":42,"type":43},10,"ESTIMATED","INTERVENTIONAL",[46],"NA","The purpose of this study is to evaluate the clinical effects of multi-segmental spinal manual therapy on pain intensity, central sensitization, and sensorimotor control in women diagnosed with episodic migraine.\n\nParticipants receive 10 sessions of a comprehensive manual therapy intervention targeting the cervical, thoracic, lumbar, and sacral regions over a 2-week period. Clinical outcomes-including headache pain intensity, sensorimotor dysfunction, headache-related disability, and cutaneous allodynia-are evaluated at baseline, immediately after the 2-week treatment, and at a 1-month follow-up.\n\nThis study aims to investigate whether addressing multiple spinal segments with manual therapy improves clinical symptoms, spinal motor control, and central pain processing in female individuals with episodic migraine.",[49],"Migraine Disorders",[51,52,53,54,55,56,57],"Episodic Migraine","Manual Therapy","Spinal Mobilization","Central Sensitization","Sensorimotor Control","Musculoskeletal Manipulations","Cutaneous Allodynia","NOT_YET_RECRUITING","2026-08-16",{"date":61,"type":62},"2026-08-19","ACTUAL",{"date":64,"type":43},"2026-09-01",{"date":66,"type":43},"2026-12-30",{"name":29,"class":6}]