[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552660":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":35,"centralContacts":41,"locations":49,"responsibleParty":66,"collaborators":68,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":10,"eligibilityCriteria":77,"healthyVolunteers":74,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Children's Hospital of Philadelphia","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Diagnostic cohort",null,"Study participants will undergo the following diagnostic tests:",[13,14,15,16],"Diagnostic Test: Chest computed tomography (CT) with angiography","Diagnostic Test: Bronchoscopy with bronchoalveolar lavage","Diagnostic Test: Echocardiography","Diagnostic Test: 24 hour esophageal pH (\"potential of hydrogen\") - multichannel intraluminal impedance (MII) monitoring (reflux testing)",[18,23,27,31],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"DIAGNOSTIC_TEST","Chest computed tomography (CT) with angiography","A CT scan uses a doughnut-shaped machine to take x-rays in a circle around the body. CT scans help doctors learn about the structure of the lungs, heart, and blood vessels in the chest. A CT scan provides more information than regular x-rays. CT w\u002Fangiography - injection of intravenous contrast during the CT to image the blood vessels within the chest.",[9],{"type":19,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"Bronchoscopy with bronchoalveolar lavage","During a bronchoscopy, a lung doctor inserts a small flexible camera into the breathing tube and main branches of the airways within the lungs. During the test, a small amount of sterile fluid is placed into the lung and then retrieved (lavage). This fluid is tested for evidence of infection.",[9],{"type":19,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Echocardiography","An echo uses sound waves to create computer pictures of the heart.",[9],{"type":19,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"24 hour esophageal pH (\"potential of hydrogen\") - multichannel intraluminal impedance (MII) monitoring (reflux testing)","24 hour pH\u002FMII testing is used to measure gastroesophageal reflux. A small feeding tube like catheter is passed through the nose or mouth into the esophagus. The catheter is used to measure the frequency and acidity of reflux episodes during a 24 hour monitoring period.",[9],[36,39],{"name":37,"affiliation":5,"role":38},"Erik Jensen, MD, MSCE","PRINCIPAL_INVESTIGATOR",{"name":40,"affiliation":5,"role":38},"Krithika Lingappan, MD, PhD",[42,46],{"name":37,"role":43,"phone":44,"phoneExt":10,"email":45},"CONTACT","267-648-2720","jensene@chop.edu",{"name":40,"role":43,"phone":47,"phoneExt":10,"email":48},"8324058684","lingappank@chop.edu",[50],{"facility":5,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-75.16362,39.95238,{"lat":61,"lon":60},[64,65],{"name":37,"role":43,"phone":44,"phoneExt":10,"email":45},{"name":40,"role":43,"phone":47,"phoneExt":10,"email":48},{"type":67,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[69],{"name":70,"class":71},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100552660","multidimensional-phenotype-classification-in-grade-3-bronchopulmonary-dysplasia-100552660",false,"NCT06475976","Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia","Inclusion Criteria (infant subjects):\n\n* Male or female infant born with gestational age \\\u003C32 weeks\n* Postmenstrual age between 36-65 weeks at enrollment\n* Receiving invasive ventilation at enrollment\n* Grade 3 BPD or grade 2 BPD with need for chronic invasive ventilation at enrollment\n* Parental informed consent (provides the consent to participate)\n\nExclusion Criteria (infant subjects):\n\n* Contraindication to 1 or more of the study diagnostic procedures\n* Family unable\u002Funlikely to commit to 2-year follow-up\n* Unlikely to survive the 6-8-week diagnostic period\n* Parental consent not provided (decline consenting for study)\n* Aneuploidy or other severe congenital abnormality not-representative in BPD\n\nAt the time of consent, a parent or guardian caregiver will be invited to participate as an enrolled dyad using the following eligibility criteria:\n\nInclusion criteria (parents\u002Fguardians):\n\n* Parent or legal guardian of an enrolled infant subject\n* Informed consent\n\nExclusion criteria (parents\u002Fguardians):\n\n* Unable\u002Funlikely to complete study procedures","ALL","1 Month","1 Year",{"count":82,"type":83},130,"ESTIMATED","OBSERVATIONAL","Bronchopulmonary Dysplasia (BPD), or chronic lung disease of prematurity, is the most consequential complication of preterm birth and is strong predictor of childhood pulmonary and neurodevelopmental disability, particularly in infants diagnosed with grade 3 BPD (ventilator dependence at 36 weeks' postmenstrual age), the most severe disease form. This study aims to (1) generate the first empirically defined phenotype classification system for grade 3 BPD developed using a rich array of objective and quantitative cardiopulmonary diagnostic, clinical, and biological data; and (2) define the association between phenotype subgroups and neurodevelopmental and respiratory outcomes through 2 years' corrected age.",[87],"Bronchopulmonary Dysplasia",[87,89,90],"BPD","Multidimensional Phenotype","2026-07-27",{"date":93,"type":94},"2026-07-28","ACTUAL",{"date":96,"type":94},"2023-12-05",{"date":98,"type":83},"2029-07-31",{"name":5,"class":6},1]