[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629359":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":25,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"The Second Hospital of Anhui Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Electroconvulsive Therapy (ECT) Group","EXPERIMENTAL","Participants with Major Depressive Disorder(MDD) receive active Electroconvulsive Therapy (ECT) according to the study protocol, in addition to their ongoing standardized pharmacotherapy. This group assesses the efficacy and cognitive effects of ECT.",[13],"Device: Electroconvulsive Therapy",{"label":15,"type":10,"description":16,"interventionNames":17},"Magnetic Seizure Therapy (MST) Group","Participants with Major Depressive Disorder (MDD) receive active Magnetic Seizure Therapy (MST) according to the study protocol, in addition to their ongoing standardized pharmacotherapy. This group assesses the efficacy and cognitive effects of MST, allowing for comparison with ECT.",[18],"Device: Magnetic Seizure Therapy",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Electroconvulsive Therapy","Electroconvulsive therapy will be administered two to four times a week according to a standardized protocol. Stimulation parameters (including intensity, target location, session number, and duration) will be individualized for each participant based on prior research to ensure targeted and safe delivery within established safety limits. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Magnetic Seizure Therapy","Magnetic seizure therapy will be administered two to four times a week according to a standardized protocol. Stimulation parameters (including intensity, target location, session number, and duration) will be individualized for each participant based on prior research to ensure targeted and safe delivery within established safety limits. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Yanghua Tian PhD","CONTACT","0551 6599 7278","zylykd@163.com",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":25,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Anhui Medical University","RECRUITING","Hefei","Anhui","China","CN",{"type":45,"coordinates":46},"Point",[47,48],117.28083,31.86389,{"lat":48,"lon":47},[51],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":52},"ayfytyh@126.com",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Yanghua Tian","Vice President of Anhui Medical University","100629359","multimodal-clinical-study-of-electroconvulsive-therapy-and-magnetic-seizure-therapy-100629359",false,"NCT07473648","Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy","Inclusion Criteria:\n\n* Aged 12-80 years;\n* Diagnosis confirmed by two psychiatrists per DSM-5;\n* Stable medication regimen pre-enrollment;\n* Indicated for neuromodulation OR with visual field defects.\n\nExclusion Criteria:\n\n* Major systemic diseases;\n* Prior neuromodulation within 3 months;\n* Pregnancy or potential pregnancy;\n* Metal implants or claustrophobia.",true,"ALL","12 Years","80 Years",{"count":68,"type":69},200,"ESTIMATED","INTERVENTIONAL",[72],"NA","To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).",[22,75,27],"Major Depressive Disorder",[77,78,79,80,81],"Electroconvulsive Therapy (ECT)","Magnetic Seizure Therapy(MST)","Major Depressive Disorder(MDD)","Electroencephalography(EEG)","Resting-state Functional MRI (fMRI)","2026-07-15",{"date":84,"type":85},"2026-07-17","ACTUAL",{"date":87,"type":85},"2025-09-01",{"date":89,"type":69},"2028-01",{"name":5,"class":6},1]