[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640457":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":24,"studyPopulation":24,"armGroups":35,"interventions":48,"overallOfficials":24,"centralContacts":58,"locations":24,"responsibleParty":67,"collaborators":24,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":24,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":24,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":24,"overallStatus":91,"whyStopped":24,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":24},{"fullName":5,"class":6},"Second Affiliated Hospital of Tsinghua University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":24},[9],{"measure":10,"description":11,"timeFrame":12},"Montgomery-Åsberg Depression Rating Scale Score","Change in short-term depressive symptom severity measured by the Montgomery-Åsberg Depression Rating Scale (MADRS), a 10-item scale with a total score ranging from 0 to 60. Higher scores indicate worse depression outcomes.","Baseline (before acupuncture), 1 hour, 24 hours, and 72 hours after acupuncture treatment.",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Positive and Negative Affect Schedule","Change in short-term positive and negative affect measured by the Positive and Negative Affect Schedule (PANAS). The PANAS consists of two 10-item subscales: Positive Affect (PA) and Negative Affect (NA), each with a total score ranging from 10 to 50. For the PA subscale, higher scores indicate better outcomes (greater positive affect). For the NA subscale, higher scores indicate worse outcomes (greater negative affect).",{"measure":18,"description":19,"timeFrame":12},"Maudsley Three-Item Visual Analogue Scale","Change in short-term subjective mood state measured by the Maudsley Three-Item Visual Analogue Scale. The scale consists of three separate visual analogue items (e.g., happiness, anxiety, depression), each scored from 0 to 100 mm (0 = absence of the feeling, 100 = extreme feeling). For the happiness item, a higher score indicates a better outcome. For the anxiety and depression items, higher scores indicate worse outcomes.",{"measure":21,"description":22,"timeFrame":23},"Snaith-Hamilton Pleasure Scale","Change in anhedonia measured by the Snaith-Hamilton Pleasure Scale (SHAPS). The scale consists of 14 items, with a total score ranging from 0 to 14 using the original scoring method. Higher scores indicate more severe anhedonia.","Baseline (before acupuncture), 24 hours and 72 hours after acupuncture treatment.",null,{"allocation":26,"interventionModel":27,"interventionModelDescription":24,"primaryPurpose":28,"observationalModel":24,"timePerspective":24,"maskingInfo":29},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":30,"maskingDescription":24,"whoMasked":31},"TRIPLE",[32,33,34],"PARTICIPANT","INVESTIGATOR","OUTCOMES_ASSESSOR",[36,42],{"label":37,"type":38,"description":39,"interventionNames":40},"Acupuncture group","EXPERIMENTAL","Acupuncture prescription: Baihui (GV20), Shenting (GV24), Yintang (GV29), Anmian (EX-HN22, bilateral), Neiguan (PC6, bilateral), Shenmen (HT7, bilateral), Sanyinjiao (SP6, bilateral), and Taichong (LR3, bilateral). Acupoint locations will be determined according to GB\u002FT 12346-2021 Nomenclature and Location of Meridian Points and GB\u002FT 40997-2021 Nomenclature and Location of Extra Points. Electroacupuncture will be applied between Baihui (GV20) and Yintang (GV29) using a 2 Hz continuous wave, with the current intensity adjusted within 0.1-1.0 mA to a level that is tolerable and non-painful for the participant. Shenting (GV24), Anmian (EX-HN22), Neiguan (PC6), Shenmen (HT7), Sanyinjiao (SP6), and Taichong (LR3) will be retained without electrical stimulation.",[41],"Procedure: Acupuncture",{"label":43,"type":44,"description":45,"interventionNames":46},"Sham Acupuncture Group","SHAM_COMPARATOR","The sham acupuncture group will receive a predefined set of non-meridian, non-acupoint locations matched in number to those used in the acupuncture group. Non-penetrating placebo needles will be used to simulate the appearance and procedure of needle insertion without penetrating the skin. Corresponding to the Baihui (GV20)-Yintang (GV29) electroacupuncture connection in the verum acupuncture group, two predefined non-meridian, non-acupoint locations on the head will be connected to the same electroacupuncture device and leads. Device settings and visual cues will be kept as similar as possible to those in the verum acupuncture group, but no electrical current will be delivered.",[47],"Procedure: Sham Acupuncture",[49,54],{"type":50,"name":51,"description":52,"armGroupLabels":53,"otherNames":24},"PROCEDURE","Acupuncture","Participants will receive standardized acupuncture treatment for mild to moderate depression according to the study protocol. Acupuncture will be administered by qualified practitioners at predefined acupoints during the treatment period.",[37],{"type":50,"name":55,"description":56,"armGroupLabels":57,"otherNames":24},"Sham Acupuncture","Participants will receive sham acupuncture as a control intervention using non-therapeutic acupuncture procedures designed to mimic acupuncture without providing active therapeutic effects.",[43],[59,64],{"name":60,"role":61,"phone":62,"phoneExt":24,"email":63},"Chunling Fan, M.D.","CONTACT","+86 10 89926000","fanjingzi1@126.com",{"name":65,"role":61,"phone":62,"phoneExt":24,"email":66},"YU MA, M.D.","mayu@tsinghua.edu.cn",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Fan Chunling,MD","Associate Chief Physician","100640457","multimodal-mri-study-of-acupunctures-rapid-antidepressant-mechanisms-and-response-prediction-in-depression-100640457",false,"NCT07611487","Multimodal MRI Study of Acupuncture's Rapid Antidepressant Mechanisms and Response Prediction in Depression","A Multimodal MRI-Based Study on the Rapid Antidepressant Mechanisms of Acupuncture and Individualized Treatment Response Prediction in Depression","Inclusion Criteria:\n\n1. Aged 18 to 59 years, and right-handed;\n2. Patients who have received systematic antidepressant treatment (including antidepressant medications, sedative-hypnotics, electroconvulsive therapy, or transcranial magnetic stimulation) within the 4 weeks prior to enrollment;\n3. Having a total score on the 17-item Hamilton Depression Rating Scale (HAMD-17) greater than 7 and less than or equal to 24;\n4. Voluntary participation in the study, with written informed consent provided by the patient themselves or their legally authorized guardian.\n\nExclusion Criteria:\n\n1. Diagnosis of other major psychiatric disorders or presence of psychotic symptoms.\n2. History of other severe somatic diseases (e.g., cardiovascular\u002Fcerebrovascular diseases, autoimmune diseases), or current\u002Fpast neurological or organic brain diseases.\n3. Current or past history of alcohol dependence or abuse of other psychoactive substances.\n4. Women who are lactating, pregnant, or menstruating.\n5. Patients who have participated in other clinical drug trials within the past 3 months.",true,"ALL","18 Years","59 Years",{"count":83,"type":84},80,"ESTIMATED","INTERVENTIONAL",[87],"NA","This study aims to investigate the rapid antidepressant effects of acupuncture and to explore the underlying brain mechanisms using multimodal MRI techniques. In addition, the study will evaluate whether individual treatment responses can be predicted based on neuroimaging and clinical data.\n\nParticipants diagnosed with mild to moderate depression will be enrolled and will receive acupuncture treatment. Depression-related clinical assessment scales and brain imaging data will be collected before and after treatment.\n\nThe results of this study may help to better understand the mechanisms of acupuncture in rapid antidepressant treatment and support the development of personalized treatment strategies.",[90],"Major Depressive Disorder","NOT_YET_RECRUITING","2026-10-02",{"date":94,"type":95},"2026-10-07","ACTUAL",{"date":97,"type":84},"2026-10-08",{"date":99,"type":84},"2028-12-31",{"name":5,"class":6}]