[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651964":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":36,"locations":42,"responsibleParty":56,"collaborators":58,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":27,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":27,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":103,"whyStopped":27,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"The Affiliated Hospital of Qingdao University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group","EXPERIMENTAL","The experimental group: on the basis of the standard six-step treatment model (decompression, adding nutrition, suppressing digestive fluid secretion, hormone, diuresis, and exercise and promoting intestinal peristalsis), a goal-directed multimodal prehabilitation intervention lasting 5 to 7 days will be superimposed and implemented during the preoperative hospitalization period, with contents including immunonutritional support, progressive physical training, and structured psychological counseling. Postoperatively, the standard perioperative Enhanced Recovery After Surgery (ERAS) protocol will be continued to be executed, and immunonutritional treatment will be strengthened.",[13,14,15],"Behavioral: Multimodal prehabilitation program","Behavioral: Standard six-step treatment","Behavioral: ERAS protocol",{"label":17,"type":18,"description":19,"interventionNames":20},"Control group","ACTIVE_COMPARATOR","The control group: preoperatively, only the standard six-step treatment protocol will be received. Postoperatively, standard Enhanced Recovery After Surgery (ERAS) protocol will be followed for perioperative management.",[14,15],[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"BEHAVIORAL","Multimodal prehabilitation program","Multimodal prehabilitation program adopts a planned, structured, repeatable, and purposeful approach, encompassing exercise, nutrition, and psychological factors.",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Standard six-step treatment","The standard six-step treatment protocol refers to: decompression, nutritional supplementation, suppression of digestive fluid secretion, hormone therapy, diuresis, exercise, and promotion of intestinal peristalsis.",[17,9],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"ERAS protocol","The core content is to adopt a series of optimized measures performed during the perioperative period on the basis of evidence-based medical findings to reduce the physiological and psychological stress of patients and to accelerate their recovery.",[17,9],[37],{"name":38,"role":39,"phone":40,"phoneExt":27,"email":41},"Yanbing Zhou, MD","CONTACT","86532-82911324","zhouyanbing@qduhospital.cn",[43],{"facility":44,"status":27,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":27},"Department of Gastrointestinal Surgery, Qingdao University Affiliated Hospital, Qingdao, Shandong 266000","Qingdao","Shandong","266003","China","CN",{"type":51,"coordinates":52},"Point",[53,54],120.38042,36.06488,{"lat":54,"lon":53},{"type":57,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR",[59,61,63,65,67,69,71,73,75,78],{"name":60,"class":6},"Yantai Yuhuangding Hospital",{"name":62,"class":6},"Rizhao People's Hospital",{"name":64,"class":6},"Weifang People's Hospital",{"name":66,"class":6},"The Second Hospital of Shandong University",{"name":68,"class":6},"Fujian Medical University Union Hospital",{"name":70,"class":6},"Fudan University",{"name":72,"class":6},"Xinjiang Medical University",{"name":74,"class":6},"Peking University People's Hospital",{"name":76,"class":77},"The First School of Clinical Medicine of Binzhou Medical University","UNKNOWN",{"name":79,"class":6},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","100651964","multimodal-prehabilitation-for-tumor-related-bowel-obstruction-100651964",false,"NCT07767760","Multimodal Prehabilitation for Tumor-Related Bowel Obstruction","Effect of Multimodal Prehabilitation on Clinical Outcomes in Patients With Tumor-Related Bowel Obstruction: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n1. Pathologically\u002Fcytologically confirmed malignant tumor (including digestive system and gynecological origin tumors); or imaging data suggesting tumor space-occupying lesions combined with multiple metastatic foci;\n2. Diagnosis of bowel obstruction (complete or incomplete) confirmed by medical history, symptoms, signs, and imaging (abdominal plain film\u002FCT), and after MDT decision-making, no emergency surgery is required, short-term conservative treatment has potential for remission, and the expected interval from conservative treatment period to planned surgery is ≥7 days;\n3. Age between 18 and 85 years;\n4. Eastern Cooperative Oncology Group (ECOG) performance status score ≤2;\n5. Expected survival ≥12 weeks;\n6. Patients and their families have full understanding of disease progression and prognosis, accept conservative treatment, and are fully mentally prepared for the high incidence of severe surgical complications; they can understand and voluntarily sign the written informed consent form, which must be signed before performing study-specified procedures.\n\nExclusion Criteria:\n\n1. Presence of acute, life-threatening complications such as strangulated bowel obstruction, electrolyte disturbances, or sepsis;\n2. Presence of intestinal necrosis, perforation, bleeding, or other conditions requiring immediate surgical treatment;\n3. ASA grade \\>IV, severe cardiac insufficiency (preoperative LVEF \\\u003C30% or NYHA grade IV), severe hepatic dysfunction (Child-Pugh grade C), and renal dysfunction (requiring CRRT);\n4. History of cerebral hemorrhage, cerebral infarction, TIA, or presence of central nervous system disease, psychiatric disease, or bedridden status within 6 months before informed consent that precludes completion of multimodal intervention;\n5. Long-term or high-dose use of immunosuppressants or glucocorticoids within 1 month before enrollment;\n6. Presence of language communication barriers, unable to independently or with family assistance understand and complete intervention and assessment;\n7. Patients currently participating in other drug or clinical interventional trials.","ALL","18 Years","85 Years",{"count":91,"type":92},394,"ESTIMATED","INTERVENTIONAL",[95],"NA","The goal of this clinical trial is to establish a multimodal prehabilitation protocol suitable for patients with tumor-related bowel obstruction during the perioperative period, and to explore its safety and efficacy; to evaluate the impact of this protocol on short-term and long-term clinical outcomes and recovery indicators.The participants will be divided into two groups. The experimental group will receive an integrated program of preoperative multi-modal pre-rehabilitation intervention combined with postoperative immune nutrition support; the control group will receive traditional perioperative management for intestinal obstruction.",[98,99],"Malignant Tumor","Prehabilitation",[99,101,102],"Malignant tumor","Bowel Obstruction","NOT_YET_RECRUITING","2026-08-14",{"date":106,"type":107},"2026-08-17","ACTUAL",{"date":109,"type":92},"2026-08-01",{"date":111,"type":92},"2028-08-01",{"name":5,"class":6},1]