[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649712":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":17,"locations":23,"responsibleParty":41,"collaborators":43,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Institut de Myologie, France","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"BMD patients Dp140+",null,"Dp140+",{"label":13,"type":10,"description":14,"interventionNames":10},"BMD patients Dp140-","Dp140-",{"label":16,"type":10,"description":10,"interventionNames":10},"Healthy subjects",[18],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Harmen REYNGOUDT, PhD","CONTACT","01 42 16 58 91","h.reyngoudt@institut-myologie.org",[24],{"facility":25,"status":10,"city":26,"state":10,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Institute of Mythology","Paris","75651","France","FR",{"type":31,"coordinates":32},"Point",[33,34],2.3488,48.85341,{"lat":34,"lon":33},[37],{"name":38,"role":20,"phone":39,"phoneExt":10,"email":40},"Tanya STOJKOVIC, Md","01 42 16 37 76","t.stojkovic@institut-myologie.org",{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[44,46,48],{"name":45,"class":6},"Paris Brain Institute (ICM)",{"name":47,"class":6},"Université Paris Cité",{"name":49,"class":6},"Association Française contre les Myopathies (AFM), Paris","100649712","multimodal-study-about-absence-of-dp140-in-becker-muscular-dystrophy-brain-muscle-imaging-cognition-and-muscle-function-100649712",false,"NCT07740057","Multimodal Study About Absence of Dp140 in Becker Muscular Dystrophy: Brain-muscle Imaging, Cognition and Muscle Function","MyoBrain-BMD","Inclusion Criteria:\n\n* Genetically confirmed diagnosis of Becker muscular dystrophy\n* Ambulant\n* Signed ICF\n\nExclusion Criteria:\n\n* Individuals presenting contraindications to MRI\n* History of allergy to contrast product\n* Individuals with history of neurological diseases interfering with the study\n* Individuals with concomitant medical conditions that could interfere with the study outcomes\n\n  * subjects who suffer from any type of cancer (or on cancer treatment)\n  * obese subjects: BMI\\>35\n  * subjects with cardiac (left-ventricular ejection fraction \\\u003C40%) and\u002For respiratory insufficiency (forced vital capacity \\\u003C 50%) and\u002For normal ECG\n* Individuals who are not yet or insufficiently stabilized on psychiatric medication\n* Any medical and social condition that may interfere with the study at the discretion of the medical coordinator\n* Guardianship",true,"MALE","18 Years","50 Years",{"count":62,"type":63},75,"ESTIMATED","OBSERVATIONAL","Monitoring patients with neuromuscular disorders is crucial but doesn't always allow for a sufficiently specific approach to all aspects of the condition. However, in the event of future treatment, it is essential for clinical and research teams to have as much information as possible about the disease, particularly regarding its physical, physiological, biological, and neurological aspects.\n\nIn this context, it was consider as vital to investigate in greater depth the links between the presence of certain dystrophin isoforms in patients and their potential impacts on cognitive, neurological, and muscular function. The results of this study could serve as a reference for future research and improve the understanding and management of this disease.\n\nAll of this data will allow for a precise evaluation of the effects of a potential treatment on the progression of the disease.",[67],"Becker Muscular Dystrophy",[69,70,71,72,73,74],"Becker","MNR","Brain","Muscle","Neuropsycology","Natural history","NOT_YET_RECRUITING","2026-07-28",{"date":78,"type":79},"2026-07-31","ACTUAL",{"date":81,"type":63},"2026-09-15",{"date":83,"type":63},"2029-12-31",{"name":5,"class":6},1]