[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657757":3},{"organization":4,"outcomesModule":7,"designInfo":31,"detailedDescription":34,"studyPopulation":35,"armGroups":36,"interventions":30,"overallOfficials":40,"centralContacts":45,"locations":30,"responsibleParty":51,"collaborators":30,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":30,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":30,"studyType":68,"phases":30,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":80,"whyStopped":30,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":30},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":30},[9],{"measure":10,"description":11,"timeFrame":12},"Prevalence of cardiac abnormalities","Proportion of patients with any cardiac abnormality detected by electrocardiography, echocardiography, or elevated cardiac biomarkers (troponin I or CK-MB).","Baseline",[14,17,20,23,27],{"measure":15,"description":16,"timeFrame":12},"Prevalence of electrocardiographic abnormalities","Proportion of patients with ECG abnormalities including rhythm disturbances, ST-segment changes, T-wave abnormalities, or conduction blocks.",{"measure":18,"description":19,"timeFrame":12},"Mean left ventricular ejection fraction (LVEF)","Mean left ventricular ejection fraction percentage measured by echocardiography.",{"measure":21,"description":22,"timeFrame":12},"Prevalence of elevated cardiac troponin I","Proportion of patients with elevated serum cardiac troponin I levels.",{"measure":24,"description":25,"timeFrame":26},"Prevalence of cardiac abnormalities at follow-up","Proportion of patients with any cardiac abnormality detected by electrocardiography, echocardiography, or elevated cardiac biomarkers at 3-month follow-up.","At 3 months",{"measure":28,"description":29,"timeFrame":26},"Mean left ventricular ejection fraction at follow-up","Mean left ventricular ejection fraction percentage measured by echocardiography at 3-month follow-up.",null,{"allocation":30,"interventionModel":30,"interventionModelDescription":30,"primaryPurpose":30,"observationalModel":32,"timePerspective":33,"maskingInfo":30},"COHORT","PROSPECTIVE","Guillain-Barré syndrome can be associated with cardiac autonomic dysfunction and myocardial involvement. This observational study will include pediatric patients (1 month to 18 years) with confirmed Guillain-Barré syndrome.\n\nParticipants will undergo electrocardiography, echocardiography, and cardiac biomarker assessment at hospital admission and at 3-month follow-up.","Pediatric patients aged 1 month to 18 years with confirmed Guillain-Barré syndrome admitted to Assiut University Children's Hospital.",[37],{"label":38,"type":30,"description":39,"interventionNames":30},"Single cohort: Pediatric patients with Guillain-Barré syndrome","Pediatric patients with confirmed Guillain-Barré syndrome who will undergo cardiac evaluation at admission and at 3-month follow-up.",[41],{"name":42,"affiliation":43,"role":44},"Faisal A Ahmed, prof","Pediatrics Department, Assiut University Hospitals","STUDY_CHAIR",[46],{"name":47,"role":48,"phone":49,"phoneExt":30,"email":50},"maria m monir, Resident","CONTACT","+20 10 20193392","mariamedmagdy@gmail.com",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Maria Magdy Monir","Resident Physician, Department of Pediatrics","100657757","myocardial-changes-in-pediatric-guillain-barr-syndrome-100657757",false,"NCT07842705","Myocardial Changes in Pediatric Guillain-Barré Syndrome","Myocardial Changes in Pediatric Patients With Guillain-Barré Syndrome","Inclusion Criteria:\n\n* Age 1 month to 18 years\n* Confirmed diagnosis of Guillain-Barré syndrome\n* Onset of neurological symptoms within 2 weeks prior to hospital presentation\n* No pre-existing cardiac disease\n* Written informed consent from parents or legal guardians\n\nExclusion Criteria:\n\n* Pre-existing congenital or acquired heart disease\n* Pre-existing neuromuscular disorders or hereditary peripheral neuropathies\n* Incomplete cardiac workup (inability to perform ECG, echocardiography, and cardiac biomarker assessment)\n* Loss to follow-up before hospital discharge","ALL","1 Month","18 Years",{"count":66,"type":67},72,"ESTIMATED","OBSERVATIONAL","This prospective cohort study aims to identify and characterize cardiac changes including electrocardiographic, echocardiographic, and biochemical abnormalities in pediatric patients with Guillain-Barré syndrome.",[71,72],"Myocardial Dysfunction","Guillain-Barre Syndrome",[74,75,76,77,78,79],"Guillain-Barré syndrome","Assiut","ECG","Echocardiography","Myocardial changes","Pediatric","NOT_YET_RECRUITING","2026-09-21",{"date":83,"type":84},"2026-09-25","ACTUAL",{"date":86,"type":67},"2026-09-26",{"date":88,"type":67},"2028-01-25",{"name":5,"class":6}]