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Capecitabine is also acceptable.\n* Estimated life expectancy \\>= 6 months.\n* Patients must be able to comprehend English or Spanish (for questionnaire completion).\n* Ability to understand and the willingness to sign a written informed consent document.\n* Patient eligibility is not dependent on BMI or weight. Patients with a significant (+- \\> 10%) body weight change in the previous 12 months are eligible for this study.\n\nExclusion Criteria:\n\n* Patients enrolled on hospice.\n* Prior systemic chemotherapy for metastatic colorectal cancer (ok if adjuvant chemotherapy completed \\>= 3 months (12 weeks) prior to this disease disease recurrence and treatment).\n* Patients may not be receiving any other investigational agents.\n* No untreated brain metastases. Patients with treated brain metastases are eligible.\n* Patients on or planned to undergo radiation therapy in near future.","ALL","60 Years",{"count":1807,"type":1808},300,"ESTIMATED","OBSERVATIONAL","This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.",[1812,1813],"Colorectal Cancer","Sarcopenia",[1812,1815,1813,1816,1817],"Myopenia","Chemotherapy","Geriatric-Oncology","2026-10-06",{"date":1820,"type":1821},"2026-10-07","ACTUAL",{"date":1823,"type":1821},"2019-09-23",{"date":1825,"type":1808},"2026-12-31",{"name":5,"class":6},147]