[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645601":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":20,"locations":20,"responsibleParty":25,"collaborators":27,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":20,"eligibilityCriteria":37,"healthyVolunteers":38,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":20,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":51,"overallStatus":54,"whyStopped":20,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":20},{"fullName":5,"class":6},"Duke University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single Arm","EXPERIMENTAL","Participants undergo oxygen prebreathe followed by hypobaric chamber exposure with exercise and monitoring.",[13],"Procedure: Oxygen Prebreathe and Hypobaric Exposure",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Oxygen Prebreathe and Hypobaric Exposure","Prebreathe 100% oxygen followed by simulated spacewalk conditions in hypobaric chamber with exercise protocols.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Richard Moon","PRINCIPAL_INVESTIGATOR",{"type":26,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[28],{"name":29,"class":30},"National Aeronautics and Space Administration (NASA)","FED","100645601","nasa-exercise-prebreathe-study-100645601",false,"NCT07702539","NASA Exercise Prebreathe Study","Exercise Prebreathe Study in Healthy Adult Volunteers to Evaluate Risk of Decompression Sickness During Simulated Spacewalk Conditions","Inclusion Criteria:\n\n* Non-smoking volunteers aged 30-60 years\n* Able to meet VO2 peak requirements (\\>35 ml\u002Fkg\u002Fmin males, \\>30 ml\u002Fkg\u002Fmin females)\n\nExclusion Criteria:\n\n* Pregnancy\n* Lung disease, heart disease, hypertension, or diabetes\n* Musculoskeletal pain conditions\n* Requirement for regular medications such as analgesics",true,"ALL","30 Years","60 Years",{"count":43,"type":44},30,"ESTIMATED","INTERVENTIONAL",[47],"NA","This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.",[50],"Decompression Sickness",[50,52,53],"Prebreathe Oxygen","Hypobaric Exposure","NOT_YET_RECRUITING","2026-07-10",{"date":57,"type":58},"2026-07-14","ACTUAL",{"date":60,"type":44},"2026-07-13",{"date":62,"type":44},"2027-02-27",{"name":5,"class":6}]