[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650517":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":36,"responsibleParty":52,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":25,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":25,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":88,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Benha University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nebulized Glubran 2-Assisted Tubeless PCNL","EXPERIMENTAL","Participants will undergo percutaneous nephrolithotomy followed by tubeless closure of the percutaneous access tract. After stone removal and confirmation of no significant collecting-system injury, 1 mL of Glubran 2 will be delivered into the tract using a special nebulizing applicator under endoscopic and fluoroscopic guidance. The tract will be temporarily occluded using the balloon of a 16 Fr Foley catheter. No nephrostomy tube will be placed. A 6 Fr double-J ureteral stent may be inserted when clinically indicated.",[13],"Procedure: Nebulized Glubran 2-Assisted Tubeless PCNL",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional PCNL With Nephrostomy Tube","ACTIVE_COMPARATOR","Participants will undergo conventional percutaneous nephrolithotomy. After stone removal, a 24 Fr Nelaton tube will be placed as a nephrostomy tube for postoperative drainage. The nephrostomy tube is planned to be removed after approximately 24 hours, according to the participant's clinical condition. A 6 Fr double-J ureteral stent may be inserted when clinically indicated.",[19],"Procedure: Conventional PCNL With Nephrostomy Tube",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Following stone removal by percutaneous nephrolithotomy, 1 mL of Glubran 2 will be nebulized into the percutaneous access tract using a special applicator under endoscopic and fluoroscopic guidance. The tract will be temporarily occluded using a 16 Fr Foley catheter balloon, and no nephrostomy tube will be placed.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Following stone removal by percutaneous nephrolithotomy, a 24 Fr Nelaton tube will be placed as a nephrostomy tube for postoperative drainage and will generally be removed after approximately 24 hours according to the participant's clinical condition.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},"Saad A Salama, MD","CONTACT","01063006039","+2","saad.ali@fmed.bu.edu.eg",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Benha University Hospital","Banhā","Qalyubia Governorate","13511","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.1842,30.45977,{"lat":48,"lon":47},[51],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Saad ali saad salama","Lecturer of Urology","100650517","nebulized-glubran-2-assisted-tubeless-pcnl-versus-conventional-pcnl-100650517",false,"NCT07749807","Nebulized Glubran 2-Assisted Tubeless PCNL Versus Conventional PCNL","A Novel Technique in Tubeless Percutaneous Nephrolithotomy Using Nebulized Glubran 2 Versus Conventional Percutaneous Nephrolithotomy: A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* Age 18 years or older.\n* Single or multiple renal stones measuring 2-3 cm.\n* Renal stones located in an anatomical position suitable for percutaneous nephrolithotomy.\n* Participant considered suitable for PCNL under general anesthesia.\n* Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Active urinary tract infection.\n* Renal stones in an anomalous kidney.\n* Uncontrolled hypertension.\n* Uncontrolled diabetes mellitus.\n* Uncorrected coagulopathy.\n* Clinically significant arrhythmia.\n* Distal ureteric obstruction.\n* Fixed hip joints preventing appropriate operative positioning.\n* Previous renal surgery.\n* Requirement for more than one percutaneous puncture.\n* Pelvicalyceal system perforation during the procedure.\n* Excessive intraoperative bleeding.\n* Any intraoperative finding requiring nephrostomy tube placement for safety.","ALL","18 Years",{"count":66,"type":67},100,"ESTIMATED","INTERVENTIONAL",[70],"NA","This prospective randomized controlled study will compare two techniques used after percutaneous nephrolithotomy, a procedure for removing kidney stones. Participants with renal stones measuring 2-3 cm will be randomly assigned to either tubeless percutaneous nephrolithotomy with nebulized Glubran 2 used to seal the access tract or conventional percutaneous nephrolithotomy with placement of a nephrostomy tube. The study will evaluate whether the Glubran 2-assisted tubeless technique is safe and effective and whether it can reduce postoperative pain, bleeding, hospital stay, urine leakage, and other complications while maintaining a satisfactory stone-free rate.",[73,74],"Kidney Calculi","Nephrolithiasis",[76,77,78,79,80,81,82,83,84,85,86,87],"Percutaneous nephrolithotomy","Tubeless percutaneous nephrolithotomy","Conventional percutaneous nephrolithotomy","Glubran 2","Cyanoacrylate tissue adhesive","Percutaneous tract sealing","Nephrostomy tube","Kidney stones","Renal calculi","Stone-free rate","Postoperative pain","Postoperative bleeding","NOT_YET_RECRUITING","2026-08-03",{"date":91,"type":92},"2026-08-06","ACTUAL",{"date":94,"type":67},"2026-09-01",{"date":96,"type":67},"2027-02-01",{"name":5,"class":6},1]