[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659768":3},{"organization":4,"outcomesModule":7,"designInfo":31,"detailedDescription":34,"studyPopulation":35,"armGroups":36,"interventions":30,"overallOfficials":30,"centralContacts":40,"locations":30,"responsibleParty":46,"collaborators":30,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":64,"studyType":65,"phases":30,"briefSummary":66,"conditions":67,"keywords":73,"overallStatus":82,"whyStopped":30,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":90,"locationsCount":30},{"fullName":5,"class":6},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":30},[9],{"measure":10,"description":11,"timeFrame":12},"Number of participants with persistent peripheral neurological deficit at 90 days after injury","Persistent peripheral neurological deficit will be assessed at 90 days after injury by clinical neurological examination and documented as present or absent, including sensory loss, motor weakness, or neuropathic symptoms attributable to peripheral nerve injury.","Mean Medical Research Council (MRC) muscle strength score at 90 days after injury",[14,18,22,26],{"measure":15,"description":16,"timeFrame":17},"Number of participants with early peripheral neurological deficit within 72 hours after injury","Early peripheral neurological deficit will be assessed within 72 hours after injury by clinical neurological examination and recorded as present or absent. Deficit includes sensory loss, motor weakness, or neuropathic symptoms consistent with peripheral nerve injury.","48 to 72 hours after the index injury.",{"measure":19,"description":20,"timeFrame":21},"Pain Intensity","Pain intensity at rest and during movement measured on the 0-10 Numeric Rating Scale.","48 to 72 hours and 90 days after the index injury.",{"measure":23,"description":24,"timeFrame":25},"Attribution of Persistent Neurological Deficit","Multidisciplinary classification of persistent neurological deficits as trauma-associated, possibly peripheral nerve block-associated, multifactorial, or indeterminate.","90 days after the index injury.",{"measure":27,"description":28,"timeFrame":29},"Number of participants with a regional anaesthesia-related safety event within 48 hours after block placement","Regional anaesthesia-related safety events will be recorded from block placement until 48 hours afterwards and reported as present or absent. Events include local anaesthetic systemic toxicity, clinically significant bleeding or haematoma, infection, persistent paraesthesia or motor deficit, nerve injury, vascular puncture, pneumothorax, or unplanned escalation of care attributable to the procedure.","From peripheral nerve block placement to 72 hours after the index injury.",null,{"allocation":30,"interventionModel":30,"interventionModelDescription":30,"primaryPurpose":30,"observationalModel":32,"timePerspective":33,"maskingInfo":30},"COHORT","PROSPECTIVE","Combat-related limb trauma is frequently accompanied by peripheral nerve injury. Neurological symptoms identified after trauma may result from the original injury, blast effects, fractures, vascular compromise, tourniquet exposure, haematoma, infection, surgery, or pain treatment. Peripheral nerve blocks are commonly used for analgesia, but determining whether a later neurological deficit is related to the block, the injury, or multiple factors is often difficult.\n\nThis prospective observational cohort study will collect routine clinical data from adults with combat-related upper- or lower-limb trauma. The study will not assign or alter treatment. Peripheral nerve blocks, surgical care, imaging, rehabilitation, and pharmacological analgesia will be provided according to clinical need and local practice.\n\nInvestigators will document injury characteristics, neurological findings before and after analgesia when feasible, regional anaesthesia details, pain outcomes, relevant imaging and follow-up neurological status. Participants with a persistent or worsening neurological deficit will undergo structured multidisciplinary case review. Events will be classified as trauma-associated, possibly block-associated, multifactorial, or indeterminate.\n\nThe study aims to describe neurological outcomes after combat limb trauma and identify factors associated with persistent deficits. The findings may support safer regional anaesthesia practice, improve documentation of baseline nerve function, and strengthen pathways for early recognition and referral of peripheral nerve injury.","Adults with combat-related upper- or lower-limb trauma treated at a specialised Ukrainian war trauma centre. The population includes patients with blast- or ballistic-related injuries, fractures, soft-tissue injury, vascular injury, traumatic amputation, or complex reconstructive needs. Patients may receive ultrasound-guided peripheral nerve blocks or routine non-regional analgesia as part of standard clinical care.",[37],{"label":38,"type":30,"description":39,"interventionNames":30},"Peripheral Nerve Block Group","Adults with combat-related upper- or lower-limb trauma who received an ultrasound-guided peripheral nerve block as part of routine clinical care. Blocks may be single-injection techniques or continuous peripheral nerve catheters. The study does not assign the block or modify clinical treatment; it records routinely delivered analgesia and subsequent neurological outcomes.",[41],{"name":42,"role":43,"phone":44,"phoneExt":30,"email":45},"Dmyto Dmytriiev, PhD.Professor","CONTACT","0674309449","dmytrodmytriiev@gmail.com",{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Dmytro Dmytriiev","professor, head of intensive care department","100659768","nerve-blocks-or-combat-trauma-what-drives-peripheral-nerve-injury-100659768",false,"NCT07868133","Nerve Blocks or Combat Trauma: What Drives Peripheral Nerve Injury?","Nerve Blocks or Combat Trauma: What Drives Peripheral Nerve Injury? A Prospective Observational Cohort Study","NERVE-COMBAT","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Combat-related traumatic injury of an upper or lower limb, including blast- or ballistic-related injury.\n* Admission to, or treatment at, the study centre during the defined study period.\n* Available clinical documentation of injury characteristics and neurological assessment sufficient for outcome evaluation.\n* Receipt of routine trauma care with or without an ultrasound-guided peripheral nerve block.\n\nExclusion Criteria:\n\n* Pre-existing neurological disease or documented chronic peripheral neuropathy that prevents reliable assessment of a new trauma-related neurological deficit.\n* Isolated injuries without involvement of an upper or lower limb.\n* Missing or insufficient medical-record data on injury characteristics, analgesia exposure, or neurological outcome.\n* Death before neurological outcome assessment.\n* Withdrawal of consent, where consent is required by the ethics committee.","ALL","18 Years","60 Years",{"count":62,"type":63},1000,"ESTIMATED","3 Months","OBSERVATIONAL","This study will examine nerve problems after combat-related injuries to the arms or legs. Some patients receive a peripheral nerve block, an injection of local anaesthetic near a nerve, to help control pain. However, combat injuries themselves can damage nerves through blast effects, fractures, blood vessel injury, bleeding, infection, surgery, or use of a tourniquet.\n\nThe study will follow adults with combat-related limb injuries who receive routine care at a specialised trauma centre. Treatment will not be assigned by the study. Researchers will record details of the injury, pain treatment, nerve block use, and nerve function over time.\n\nThe main goal is to determine how often patients have new or worsened numbness, weakness, or nerve pain after injury, and whether these problems are more closely related to the injury itself, the nerve block, or several factors together. The findings may help clinicians provide safer pain treatment and recognise nerve problems earlier.",[68,69,70,71,72],"Combat-Related Limb Injury","Nerve Block","Nerve Damage","Nerve Blocks","Neurological Complications",[74,75,76,77,78,79,80,81],"Peripheral nerve block;","Regional anaesthesia","Combat trauma","Peripheral nerve injury","Neurological complications","Limb trauma","Ultrasound-guided regional anaesthesia","Pain management","NOT_YET_RECRUITING","2026-10-06",{"date":85,"type":86},"2026-10-09","ACTUAL",{"date":88,"type":63},"2026-10-31",{"date":88,"type":63},{"name":5,"class":6}]