[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646245":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":27,"locations":37,"responsibleParty":50,"collaborators":24,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":24,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":76,"overallStatus":79,"whyStopped":24,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Anhui Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"BPSD real group","EXPERIMENTAL","Stimulation delivered by a real coil through MagStim Rapid2 and guided by BrainSight navigation system.",[13],"Other: transcranial magnetic stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"BPSD sham group","SHAM_COMPARATOR","Stimulation delivered by a sham coil through MagStim Rapid2 and guided by BrainSight navigation system.",[13],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"transcranial magnetic stimulation","Neuronavigated Theta-Burst Transcranial Magnetic Stimulation\n\nOther Name:",[9],null,{"type":6,"name":21,"description":22,"armGroupLabels":26,"otherNames":24},[15],[28,33],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},"Kai Wang","CONTACT","+86-0551-62922263","wangkai1964@126.com",{"name":34,"role":30,"phone":35,"phoneExt":24,"email":36},"Xingqi Wu","+86 18134516380","wuxingqi09@163.com",[38],{"facility":5,"status":24,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":24},"Hefei","Anhui","230000","China","CN",{"type":45,"coordinates":46},"Point",[47,48],117.28083,31.86389,{"lat":48,"lon":47},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","WANG KAI","Director of medical psychological department, Anhui Medical University","100646245","network-guided-individualized-tms-for-bpsd-in-alzheimers-disease-a-double-blind-randomized-controlled-trial-100646245",false,"NCT07692542","Network-Guided Individualized TMS for BPSD in Alzheimer's Disease: A Double-blind Randomized Controlled Trial","The Safety and Efficacy of Functional Impairment Network-Guided Individualized Transcranial Magnetic Stimulation for Behavioral and Psychological Symptoms in Alzheimer's Disease (NET-BPSD): A Randomized, Double-blind, Sham-Controlled Trial","NET-BPSD","Inclusion Criteria:\n\n* 1.Diagnosis of Alzheimer's disease according to the 2011 NIA-AA diagnostic criteria. 2.Mini-Mental State Examination (MMSE) score between 10 and 24; 3.Clinical Dementia Rating (CDR) score between 0.5 and 2; 4.Neuropsychiatric Inventory (NPI) score ≥4; 5.Education duration ≥5 years, or ability to complete the required cognitive and neuropsychological assessments; 6.Age ≥50 years and right-handedness; 7.Stable use of anti-dementia medications, including an NMDA receptor antagonist and\u002For cholinesterase inhibitors, for at least one month before rTMS intervention; 8.The patient and his or her family member or legal representative are able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* 1\\. Recevied rTMS treatment in the past 3 months. 2. Depression or other psychiatric disorders. 3. History of head injury, stroke, epilepsy or other neurologic disease. 4. Organic brain defects on T1 or T2 images. 5. History of unexplained loss of consciousness. 6. Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, or any implanted medical device that is incompatible with MRI. 7. Family history of medication refractory epilepsy. 8. History of substance abuse within the last 6 months.","ALL","50 Years","90 Years",{"count":66,"type":67},40,"ESTIMATED","INTERVENTIONAL",[70],"NA","Evaluate the safety and efficacy of personalized network-guided transcranial magnetic stimulation for treating behavioral and psychological symptoms in patients with Alzheimer's disease.",[73,74,75],"Transcranial Magnetic Stimulation","Behavioral and Psychological Symptoms in Alzheimer's Disease","Individualized Navigation",[77,73,78],"behavioral and psychological symptoms in Alzheimer's disease","Individualized navigation","NOT_YET_RECRUITING","2026-07-03",{"date":82,"type":83},"2026-07-09","ACTUAL",{"date":85,"type":67},"2026-07-01",{"date":87,"type":67},"2027-02",{"name":5,"class":6},1]