[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643110":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":26,"locations":36,"responsibleParty":55,"collaborators":59,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":20,"eligibilityCriteria":68,"healthyVolunteers":65,"sex":69,"minAge":70,"maxAge":20,"enrollmentInfo":71,"targetDuration":20,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Epilepsy patients","All participants will be patients with medically refractory epilepsy who have undergone depth electrode placement for stereo EEG monitoring for seizure localization. Participants will complete working memory tasks and EEG recordings will be concurrently collected from their depth electrodes. Some subjects will undergo macro-micro electrode implantation as a part of their SEEG implantation procedure for the purpose of EEG macro (local activity) and micro (single-unit) recordings. Some subjects will complete working memory tasks with stimulation applied during task completion.",[12,13],"Behavioral: Neurocognitive Tasks","Device: Ripple Neuromed Summit System",[15,21],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Neurocognitive Tasks","Participants complete computerized neurocognitive tasks assessing working memory, response inhibition, decision-making, reward processing, and other related cognitive functions during sEEG monitoring. Tasks may include the stop signal reaction time task, the n-back working memory task, the delayed response task, the match\u002Fnonmatch task, the gambling task, the card guessing task, and the emotional stop signal reaction time task. Intracranial neural activity is recorded during task performance, and select tasks may include research electrical stimulation delivered through the implanted sEEG electrodes.",[9],null,{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":20},"DEVICE","Ripple Neuromed Summit System","Neurophysiology system designed to allow recording of neural signals as well as delivery of neural stimulation. The system is a portable unit which is connected to cables connected to the clinical electrodes. Neurophysiology signals from the electrodes can be recorded, amplified, and processed by the unit. The unit also has the ability to deliver electrical stimulation through the electrodes according to programmed parameters.",[9],[27,32],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Lucas Chang, BS","CONTACT","615-421-3046","lucas.m.chang@vumc.org",{"name":33,"role":29,"phone":34,"phoneExt":20,"email":35},"Christos Constantinidis, PhD","+1 (615) 936-2020","christos.constantinidis.1@Vanderbilt.Edu",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Nashville","Tennessee","37232","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-86.78444,36.16589,{"lat":48,"lon":47},[51,53],{"name":52,"role":29,"phone":30,"phoneExt":20,"email":31},"Lucas Chang, BA",{"name":33,"role":29,"phone":54,"phoneExt":20,"email":35},"(615) 936 - 2020",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Christos Constantinidis","Professor of Biomedical Engineering, Principal Investigator",[60],{"name":61,"class":62},"National Institute of Mental Health (NIMH)","NIH","100643110","neural-basis-of-human-working-memory-100643110",false,"NCT07617506","Neural Basis of Human Working Memory","Inclusion Criteria:\n\n* Undergoing SEEG monitoring at Vanderbilt University Medical Center\n* Age \\>18\n* English speaking\n\nExclusion Criteria:\n\n* Age \\\u003C18\n* Not able to complete questionnaires (unable to comprehend instructions or follow directions)","ALL","18 Years",{"count":72,"type":73},100,"ESTIMATED","INTERVENTIONAL",[76],"NA","This ClinicalTrials.gov entry corresponds to the Neural Basis of Human Working Memory protocol approved under Vanderbilt University Medical Center IRB #251231.\n\nThis study investigates the neural activity underlying human working memory, via local field potential changes (macro level) and\u002For single neuronal spiking changes (micro level) from depth electrodes placed for invasive seizure monitoring. Subjects will complete neurocognitive tasks while neural recordings are collected. Some patients will complete neurocognitive tasks while stimulation is applied via depth electrodes. Further understanding the neural activity changes underlying normal and impaired working memory may help to identify novel diagnostic methods and treatments for impaired working memory and may support the use of stimulation for treatment of memory disorders.",[79],"Memory Disorders",[81,82,83,84],"Neural stimulation","Memory disorders","Working Memory","Stereo Electroencephalography (SEEG)","2026-08-18",{"date":87,"type":88},"2026-08-20","ACTUAL",{"date":90,"type":88},"2025-06-04",{"date":92,"type":73},"2027-04",{"name":5,"class":6},1]