[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647355":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":10,"centralContacts":10,"locations":43,"responsibleParty":68,"collaborators":10,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":10,"studyType":87,"phases":10,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Asian Institute of Gastroenterology, India","OTHER",[8,17,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Painful Chronic Pancreatitis",null,"Patients diagnosed with chronic pancreatitis (CP) confirmed by CECT, MRCP, or EUS (based on Cambridge or Rosemont criteria), who experience significant abdominal pain.",[13,14,15,16],"Diagnostic Test: Comprehensive Neuropsychological Assessment","Diagnostic Test: Resting-State Functional MRI (fMRI)","Diagnostic Test: Magnetic Resonance Spectroscopy (MRS)","Diagnostic Test: Blood-Based Metabolite Profiling",{"label":18,"type":10,"description":19,"interventionNames":20},"Painless Chronic Pancreatitis","Patients diagnosed with chronic pancreatitis who do not experience abdominal pain, serving as a disease control group",[13,14,15,16],{"label":22,"type":10,"description":23,"interventionNames":24},"Healthy Controls","Age- and sex-matched individuals without any pancreatic or systemic diseases, serving as a healthy control group",[13,14,15,16],[26,31,35,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"DIAGNOSTIC_TEST","Comprehensive Neuropsychological Assessment","A comprehensive set of clinical and neurological tests to be performed on all participants. This includes validated mental state and sleep evaluations (HADS, PSQI), quality-of-life assessments (EORTC QLQ-C30 + PAN28),and quantitative sensory testing (P-QST)",[22,9,18],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Resting-State Functional MRI (fMRI)","An advanced neuroimaging scan performed on all participants to assess resting-state functional connectivity within key pain-processing networks.",[22,9,18],{"type":27,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"Magnetic Resonance Spectroscopy (MRS)","A neuroimaging technique performed on all participants to quantify brain metabolites in key brain regions.",[22,9,18],{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":10},"Blood-Based Metabolite Profiling","Blood samples will be collected from all participants to quantify metabolomic signatures and to identify potential correlates with pain phenotypes in chronic pancreatitis.",[22,9,18],[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Asian Institute of Gastroenterology","RECRUITING","Hyderabad","Telangana","500032","India","IN",{"type":53,"coordinates":54},"Point",[55,56],78.45636,17.38405,{"lat":56,"lon":55},[59,64],{"name":60,"role":61,"phone":62,"phoneExt":10,"email":63},"Abdul Rasheed, Pharm.D","CONTACT","+91 9652104726","abdulrasheedmd1223@gmail.com",{"name":65,"role":61,"phone":66,"phoneExt":10,"email":67},"Rupjyoti Talukdar, MD","+91 7032804231","rup_talukdar@yahoo.com",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Rupjyoti Talukdar","Director, Pancreatology","100647355","neural-sensitisation-and-neuropsychological-alterations-in-painful-chronic-pancreatitis-100647355",false,"NCT07707609","Neural Sensitisation and Neuropsychological Alterations in Painful Chronic Pancreatitis","EVALUATION OF THE RELATIONSHIP BETWEEN NEURAL SENSITISATION AND NEUROPSYCHOLOGICAL ALTERATIONS IN PATIENTS WITH PAINFUL CHRONIC PANCREATITIS","NEURO-CP","Inclusion Criteria:\n\n* Diagnosed with CP confirmed by CECT, MRCP, or EUS based on Cambridge or Rosemont criteria.\n* Age 18-60 years.\n* Both genders\n\nExclusion Criteria:\n\n* Recent episode of acute pancreatitis or ongoing pain (VAS \\>5).\n* Pancreatic cancer and other significant comorbidities.\n* Recent use of antidepressants, anxiolytics, high-potency opioids, or neuromodulators.\n* Pregnancy and lactation.\n* Inability to give informed consent.",true,"ALL","18 Years","60 Years",{"count":85,"type":86},200,"ESTIMATED","OBSERVATIONAL","Chronic pancreatitis (CP) is a progressive inflammatory disease in which chronic abdominal pain affects up to 80% of patients and remains difficult to manage despite treatment of pancreatic pathology. Increasing evidence suggests that persistent pain is not solely driven by peripheral pancreatic abnormalities but also by central sensitization, involving maladaptive changes in central nervous system pain-processing pathways. While altered brain connectivity and neurochemical changes have been demonstrated in other chronic pain disorders, these mechanisms remain poorly characterized in CP.\n\nThis study aims to integrate clinical phenotyping with blood-based metabolite profiling and advanced neuroimaging, including resting-state functional MRI and magnetic resonance spectroscopy, to investigate the relationship between central sensitization, brain dysfunction, and neuropsychological alterations. The findings may identify objective neurobiological markers of pain and facilitate the development of mechanism-based, personalized treatment strategies for patients with chronic pancreatitis.",[90,91],"Chronic Pancreatitis","Pain Management",[93,94,95,96,97,90],"Central Sensitisation","Pain","Neuroimaging","fMRI","MRS","2026-07-13",{"date":100,"type":101},"2026-07-16","ACTUAL",{"date":103,"type":101},"2026-01-06",{"date":105,"type":86},"2026-11-30",{"name":5,"class":6},1]