[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651459":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":34,"centralContacts":38,"locations":48,"responsibleParty":69,"collaborators":72,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":23,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":103,"overallStatus":112,"whyStopped":23,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Online Cohort","EXPERIMENTAL","The online cohort will include 718 adults ages 18-100 who will complete 1) a battery of behavioral tasks designed to assess social learning and mentalizing abilities, and 2) self-report measures assessing personality, externalizing symptoms, interpersonal functioning, and psychopathology.",[13],"Behavioral: Social Learning Task Battery, Online Cohort",{"label":15,"type":10,"description":16,"interventionNames":17},"Clinical Cohort","The study will enroll up to 416 clinical-cohort participants, with an anticipated final eligible sample of 239 adults ages 20-60 who will complete 1) a structured clinical interview and neuropsychological assessments, 2) self-report measures assessing personality, externalizing symptoms, interpersonal functioning, and psychopathology, 3) lab-based tasks designed to assess social learning and mentalizing abilities while monitoring physiological responding with Biopac, 4) task-based fMRI, 5) 21-day ecological momentary assessment (EMA) protocol, and 6) additional self-report questionnaires at three yearly follow-ups. The investigators expect to enroll 416 participants for the start of the protocol to yield 239 final eligible participants to complete fMRI and EMA.",[18],"Behavioral: Social Learning Task Battery, Clinical Cohort",{"label":20,"type":21,"description":22,"interventionNames":23},"Informants","NO_INTERVENTION","Additionally, 2 informants (ages 18+) for each participant will be recruited to complete self-report measures, one of whom will also enroll in EMA.",null,[25,30],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":23},"BEHAVIORAL","Social Learning Task Battery, Clinical Cohort","In the primary study task, participants engage in a modified iterative trust game. The task is completed in the fMRI scanner and takes about 35 minutes. Participant choices earn feedback in the form of monetary gains or losses. All participants are debriefed on the motivation behind the task at the end of their visit.",[15],{"type":26,"name":31,"description":32,"armGroupLabels":33,"otherNames":23},"Social Learning Task Battery, Online Cohort","In the primary study task, participants engage in a modified iterative trust game. Participant choices earn feedback in the form of monetary gains or losses. All participants are debriefed on the motivation behind study task at the end of their visit.",[9],[35],{"name":36,"affiliation":5,"role":37},"Timothy A Allen, PhD","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":23,"email":43},"Michelle M Berry, MPS","CONTACT","424-380-1194","berrymic@pitt.edu",{"name":45,"role":41,"phone":46,"phoneExt":23,"email":47},"Amanda Collier, BS","412-901-2938","collieral@upmc.edu",[49],{"facility":50,"status":23,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"University of Pittsburgh, Bellefield Towers","Pittsburgh","Pennsylvania","15213","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-79.99589,40.44062,{"lat":60,"lon":59},[63,64,65,66],{"name":40,"role":41,"phone":42,"phoneExt":23,"email":43},{"name":45,"role":41,"phone":46,"phoneExt":23,"email":47},{"name":36,"role":37,"phone":23,"phoneExt":23,"email":23},{"name":67,"role":68,"phone":23,"phoneExt":23,"email":23},"Alexandre Dombrovski, MD","SUB_INVESTIGATOR",{"type":37,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Timothy Allen","Assistant Professor",[73,75,77],{"name":74,"class":6},"University of Pittsburgh Medical Center",{"name":76,"class":6},"Emory University",{"name":78,"class":79},"National Institute of Mental Health (NIMH)","NIH","100651459","neurocomputational-dynamics-of-cooperation-100651459",false,"NCT07759973","Neurocomputational Dynamics of Cooperation","COBRA","Online cohort inclusion criteria:\n\n* English fluency\n* US residency\n* Owner of a desktop or laptop computer\n* Adult aged 18-100\n\nOnline cohort exclusion criteria:\n\n* Participants who have participated in an earlier version of the study\n* Inability to consent\n* Self-reported history of neurological disorder or brain damage\n* Self-endorsed history of psychosis or mania\n\nClinical cohort inclusion criteria:\n\n* Adult aged 20-60 years old\n* English fluency\n* Owner of a smartphone with celluar data\n\nClinical cohort exclusion criteria:\n\n* Inability to consent\n* Self-reported history of neurological disorder or brain damage\n* Clinician-rated psychosis or mania in the last 6 months\n* Current intoxication or withdrawal\n* Estimated IQ \\\u003C 70\n* fMRI safety concerns\n* Pregnancy\n* Lack of stable psychiatric treatment (e.g., medication dosage, therapy modality) for the previous two months\n\nInformant inclusion criteria:\n\n* Adult aged 18+ years old\n* English fluency\n* Owner of a smartphone with celluar data\n* Must have 4+ interactions\u002Fweek with the participant for at least 6 months prior to study baseline\n\nInformant exclusion criteria:\n\n\\- Lack of a smartphone with cellular data at study baseline",true,"ALL","18 Years","100 Years",{"count":92,"type":93},1612,"ESTIMATED","INTERVENTIONAL",[96],"NA","The purpose of this study is to understand brain function, how people make decisions when they interact with others, and how brain function and behavior relate to personality traits.",[99,100,101,102],"Social Cognition","Personality Disorder","Mental Health","Interpersonal Conflict",[101,104,105,106,107,108,109,110,111],"Multi-informant EMA","Neuroimaging","fMRI","Informant","Multi-method","Ecological Momentary Assessment","Self-report","Longitudinal","NOT_YET_RECRUITING","2026-08-06",{"date":115,"type":116},"2026-08-12","ACTUAL",{"date":118,"type":93},"2026-09-01",{"date":120,"type":93},"2031-06-30",{"name":5,"class":6},1]