[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653812":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":30,"studyPopulation":31,"armGroups":32,"interventions":38,"overallOfficials":43,"centralContacts":48,"locations":58,"responsibleParty":75,"collaborators":26,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":26,"enrollmentInfo":87,"targetDuration":26,"studyType":90,"phases":26,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":61,"whyStopped":26,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Hopitaux de Saint-Maurice","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":26},[9],{"measure":10,"description":11,"timeFrame":12},"Distribution of Neuromuscular Profiles","Participants will be classified into neuromuscular profiles based on the combined pattern of isokinetic strength and surface electromyographic activation of the quadriceps and hamstrings. The primary outcome will be the proportion of participants belonging to each identified neuromuscular profile, expressed as a percentage of the study population.","During the single study visit, between 4 and 12 months after ACL reconstruction",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"Surface Electromyographic Activity During the Single Leg Hop for Distance","Surface electromyographic activity of the vastus medialis, vastus lateralis, semitendinosus, and biceps femoris recorded during the Single Leg Hop for Distance.",{"measure":18,"description":19,"timeFrame":12},"Distribution of Participants Across Neuromuscular Profile","Proportion of participants belonging to each neuromuscular profile defined from the observed combinations of isokinetic strength deficit and level of surface electromyographic activation.",{"measure":21,"description":22,"timeFrame":12},"Correlation Between Neuromuscular Parameters and Functional and Patient-Reported Outcomes","Correlations between neuromuscular parameters and functional and patient-reported outcomes will be assessed using correlation coefficients. Functional performance will be assessed using the Single Leg Hop for Distance. Patient-reported outcomes will include scores from the Knee Self-Efficacy Scale (K-SES), Tampa Scale for Kinesiophobia (TSK), and International Knee Documentation Committee (IKDC) questionnaire. Correlation coefficients will range from -1 to +1, with values closer to -1 or +1 indicating stronger correlations and values closer to 0 indicating weaker correlations.",{"measure":24,"description":25,"timeFrame":12},"Completeness of Neuromuscular and Functional Assessment Data","Percentage of participants with complete data available for the planned analyses, including isokinetic strength, surface electromyography, Single Leg Hop for Distance, and patient-reported questionnaire data. Data completeness will be calculated as the number of participants with complete datasets divided by the total number of participants included in the study, multiplied by 100.",null,{"allocation":26,"interventionModel":26,"interventionModelDescription":26,"primaryPurpose":26,"observationalModel":28,"timePerspective":29,"maskingInfo":26},"COHORT","CROSS_SECTIONAL","Persistent muscle strength deficits are frequently observed after anterior cruciate ligament (ACL) reconstruction and may be related to both peripheral muscular factors and alterations in neuromuscular activation. However, few studies have simultaneously assessed isokinetic strength and electromyographic activation of both agonist and antagonist muscles under analytical and functional conditions.\n\nNEURO-ACL-ISOEMG is a monocentric, observational, cross-sectional, exploratory study designed to characterize neuromuscular profiles in patients evaluated between 4 and 12 months after ACL reconstruction.\n\nThe primary objective is to describe the joint distribution of isokinetic muscle strength and surface electromyographic activation parameters of the quadriceps and hamstrings. Isokinetic assessment includes quadriceps and hamstring peak torque and the Limb Symmetry Index (LSI). Surface electromyography is used to assess activation of the vastus medialis, vastus lateralis, semitendinosus, and biceps femoris during standardized isometric contractions.\n\nSecondary objectives include describing electromyographic patterns during a single-leg functional task, exploring the concordance between electromyographic parameters obtained under analytical and functional conditions, describing the distribution of patients according to different combinations of isokinetic strength and electromyographic activation, and exploring associations between neuromuscular profiles, functional performance, and psychological factors. The study also assesses the completeness and usability of data obtained from the functional assessment in routine clinical practice.\n\nParticipants undergo a single study visit during their routine functional assessment after ACL reconstruction. Routine assessment includes isokinetic strength measurements and a single-leg hop test. For the purposes of the study, surface electromyography and three patient-reported questionnaires are added: the Knee Self-Efficacy Scale (K-SES), the Tampa Scale for Kinesiophobia (TSK), and the International Knee Documentation Committee (IKDC) questionnaire.\n\nThe study does not modify the participants' therapeutic management and is not intended to establish an individual diagnosis. Its purpose is to provide an exploratory characterization of the heterogeneity of neuromuscular recovery after ACL reconstruction and to generate hypotheses that may contribute to the interpretation of functional assessments and future rehabilitation strategies.","Adults who underwent anterior cruciate ligament (ACL) reconstruction and are evaluated between 4 and 12 months postoperatively during a routine functional assessment at the study site.",[33],{"label":34,"type":26,"description":35,"interventionNames":36},"Patients After ACL Reconstruction","Adults evaluated between 4 and 12 months after anterior cruciate ligament (ACL) reconstruction as part of their routine functional assessment. Participants undergo isokinetic strength assessment and a single-leg hop test as part of routine care, complemented for the study by surface electromyography and patient-reported questionnaires assessing knee self-efficacy, kinesiophobia, symptoms, and knee function.",[37],"Other: Neuromuscular and Patient-Reported Assessmen",[39],{"type":6,"name":40,"description":41,"armGroupLabels":42,"otherNames":26},"Neuromuscular and Patient-Reported Assessmen","Surface electromyography of the quadriceps and hamstrings is performed using surface electrodes. Participants also complete the Knee Self-Efficacy Scale (K-SES), Tampa Scale for Kinesiophobia (TSK), and International Knee Documentation Committee (IKDC) questionnaire. These assessments are performed during the same visit as the routine functional assessment.",[34],[44],{"name":45,"affiliation":46,"role":47},"Sylvain BS BELOT, md","Hopitaux Paris Est Val-de-Marne","PRINCIPAL_INVESTIGATOR",[49,54],{"name":50,"role":51,"phone":52,"phoneExt":26,"email":53},"Sylvain SB BELOT, MD","CONTACT","+33143966383","sylvain.belot@hpevm.fr",{"name":55,"role":51,"phone":56,"phoneExt":26,"email":57},"Auriane AS SLAMA","+33143967556","auriane.slama@hpevm.fr",[59],{"facility":60,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Hôpitaux Paris Est Val-de-Marne - Service de rééducation orthopédique et traumatologie","RECRUITING","Saint-Maurice","Demande","94410","France","FR",{"type":68,"coordinates":69},"Point",[70,71],2.42716,48.82182,{"lat":71,"lon":70},[74],{"name":55,"role":51,"phone":56,"phoneExt":26,"email":57},{"type":76,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100653812","neuromuscular-profiles-after-anterior-cruciate-ligament-reconstruction-100653812",false,"NCT07792863","Neuromuscular Profiles After Anterior Cruciate Ligament Reconstruction","Exploratory Study of Neuromuscular Profiles After Anterior Cruciate Ligament Reconstruction in Clinical Conditions: Combined Analysis of Isokinetic Strength and Surface Electromyography","NEURO-ACL-ISOE","Inclusion Criteria:\n\n* Anterior cruciate ligament (ACL) reconstruction.\n* Postoperative period between 4 and 12 months.\n* Age 18 years or older.\n* Affiliation with or beneficiary of a social security scheme.\n* Ability to understand the study information and to express non-opposition to participation.\n\nExclusion Criteria:\n\n* Persons under guardianship, curatorship, or another legal protection measure.\n* Any condition preventing safe performance of isokinetic testing, including significant pain, significant joint effusion, substantial limitation of joint range of motion, clinical knee instability, or an ongoing postoperative complication.\n* Opposition to participation in the study.","ALL","18 Years",{"count":88,"type":89},30,"ESTIMATED","OBSERVATIONAL","The NEURO-ACL-ISOEMG study is an observational, cross-sectional, exploratory study conducted in patients between 4 and 12 months after anterior cruciate ligament (ACL) reconstruction.\n\nThe primary objective is to describe the joint distribution of isokinetic muscle strength and surface electromyographic (sEMG) activation parameters of the quadriceps and hamstrings in order to explore different neuromuscular profiles under clinical conditions.\n\nThe study combines data from the routine functional assessment, including isokinetic strength measurements and a single-leg hop test, with surface electromyography and patient-reported questionnaires assessing knee self-efficacy, kinesiophobia, symptoms, and knee function.",[93],"Anterior Cruciate Ligament Injury",[95,96,97,98,99,100,101,102],"Anterior Cruciate Ligament Reconstruction","Neuromuscular Recovery","Isokinetic Strength","Surface Electromyography","Quadriceps","Hamstrings","Muscle Activation","Functional Assessment","2026-09-28",{"date":105,"type":106},"2026-09-29","ACTUAL",{"date":108,"type":106},"2026-08-21",{"date":110,"type":89},"2026-12-31",{"name":5,"class":6},1]