[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654900":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":30,"studyPopulation":31,"armGroups":26,"interventions":26,"overallOfficials":32,"centralContacts":37,"locations":26,"responsibleParty":43,"collaborators":26,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":26,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":26,"enrollmentInfo":56,"targetDuration":59,"studyType":60,"phases":26,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":71,"whyStopped":26,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":26},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":26},[9],{"measure":10,"description":11,"timeFrame":12},"Neutrophil-to-lymphocyte ratio (NLR) in H. pylori-associated gastritis","Neutrophil-to-lymphocyte ratio calculated from complete blood count in patients with confirmed H. pylori-associated gastritis compared with patients without H. pylori infection.","Baseline",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"Platelet-to-lymphocyte ratio (PLR)","Platelet-to-lymphocyte ratio calculated from complete blood count in patients with and without H. pylori infection.",{"measure":18,"description":19,"timeFrame":12},"Diagnostic performance of NLR","Sensitivity, specificity, and optimal cutoff value of NLR for predicting H. pylori infection using receiver operating characteristic (ROC) curve analysis.",{"measure":21,"description":22,"timeFrame":12},"Diagnostic performance of PLR","Sensitivity, specificity, and optimal cutoff value of PLR for predicting H. pylori infection using ROC curve analysis.",{"measure":24,"description":25,"timeFrame":12},"Correlation of NLR and PLR with severity of gastritis","Correlation coefficient between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values and the severity grade of gastritis based on endoscopic and\u002For histopathological findings, using Spearman or Pearson correlation as appropriate.",null,{"allocation":26,"interventionModel":26,"interventionModelDescription":26,"primaryPurpose":26,"observationalModel":28,"timePerspective":29,"maskingInfo":26},"CASE_ONLY","CROSS_SECTIONAL","Helicobacter pylori is a major cause of gastritis and is associated with chronic gastric inflammation. Systemic inflammatory markers derived from complete blood count, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been proposed as simple and inexpensive indicators of inflammation.\n\nThis cross-sectional study will include adult patients with dyspepsia undergoing testing for H. pylori by endoscopy and biopsy at Assiut University Hospitals. Complete blood count will be performed to calculate NLR and PLR. The study will assess the association of these ratios with the presence of H. pylori infection and the severity of gastritis.","Adult patients with dyspepsia undergoing endoscopy and biopsy for H. pylori testing at Assiut University Hospitals.",[33],{"name":34,"affiliation":35,"role":36},"Rania m Hafez, prof","Internal Medicine Department, Assiut University Hospitals","STUDY_CHAIR",[38],{"name":39,"role":40,"phone":41,"phoneExt":26,"email":42},"Hadeer A Mohamed, Resident","CONTACT","+20 11 25445957","Hadeer.18313571@med.aun.edu.eg",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Hadeer Abdelaal Mohamed Mohamed","Resident Physician, Department of Internal Medicine","100654900","nlr-and-plr-in-h-pylori-associated-gastritis-100654900",false,"NCT07805005","NLR and PLR in H. Pylori-Associated Gastritis","Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Helicobacter Pylori-Associated Gastritis","Inclusion Criteria:\n\n* \\- Age 18 years or older\n* Patients with dyspepsia\n* Patients undergoing endoscopy and biopsy for H. pylori testing\n* Willingness to provide informed consent\n\nExclusion Criteria:\n\n* \\- Hematological diseases\n* Active infection other than H. pylori\n* Chronic inflammatory or autoimmune diseases\n* Malignancy\n* Recent use of steroids or immunosuppressive drugs\n* Recent acute bleeding","ALL","18 Years",{"count":57,"type":58},90,"ESTIMATED","1 Day","OBSERVATIONAL","This cross-sectional study aims to evaluate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammatory markers in patients with Helicobacter pylori-associated gastritis at Assiut University Hospitals.",[63,64,65],"Helicobacter Pylori Infection","Gastritis","Dyspepsia",[67,68,69,64,70],"Helicobacter pylori","Neutrophil-to-lymphocyte ratio","Platelet-to-lymphocyte ratio","Inflammatory markers","NOT_YET_RECRUITING","2026-09-03",{"date":74,"type":75},"2026-09-09","ACTUAL",{"date":77,"type":58},"2026-09-01",{"date":79,"type":58},"2028-05-01",{"name":5,"class":6}]