[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648364":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":13,"locations":19,"responsibleParty":35,"collaborators":10,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":10,"eligibilityCriteria":45,"healthyVolunteers":41,"sex":46,"minAge":47,"maxAge":10,"enrollmentInfo":48,"targetDuration":10,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Assiut University","OTHER",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"SLE without nephritis",null,{"label":12,"type":10,"description":10,"interventionNames":10},"SLE with nephritis",[14],{"name":15,"role":16,"phone":17,"phoneExt":10,"email":18},"nada abdelsalam nada abdelsalam hassan, MSc","CONTACT","+20 01003562354","nada011450@med.aun.edu.eg",[20],{"facility":21,"status":10,"city":22,"state":23,"zip":10,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Assuit university hospitals","Asyut","Assuit","Egypt","EG",{"type":27,"coordinates":28},"Point",[29,30],31.18368,27.18096,{"lat":30,"lon":29},[33],{"name":34,"role":16,"phone":17,"phoneExt":10,"email":18},"Nada Abdelsalam, MSc",{"type":36,"investigatorFullName":37,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Nada Abdelsalam Hasan","phd student in internal medicine","100648364","non-invasive-assessment-of-subclinical-atherosclerosis-and-cardiovascular-risk-using-tyg-index-in-lupus-nephritis-100648364",false,"NCT07719322","Non Invasive Assessment of Subclinical Atherosclerosis and Cardiovascular Risk Using TYG Index in Lupus Nephritis","Non Invasive Assessment of Subclinical Atherosclerosis in Relation to Triglyceride-Glucose (TyG) Index and Cardiovascular Risk in Lupus Nephritis a Single Center study_Assuit University","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Diagnosis of SLE according to the 2019 ACR\u002FEULAR classification criteria for systemic lupus erythematosus.\n\n  * Lupus nephritis , classified according to the 2018 ISN\u002FRPS classification of lupus nephritis.\n\nExclusion Criteria:\n\n* Established cardiovascular disease (MI, stroke, PAD)\n* Diabetes mellitus\n* Hypertension\n* Patient with CKD\n* infections\n* other autoimmune diseases\n* Pregnancy\n* Malignancy\n* chronic liver disease\n* Dyslipidemia\n* Obesity\n* Patients on lipid lowering therapy","ALL","19 Years",{"count":49,"type":50},156,"ESTIMATED","OBSERVATIONAL","Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by loss of immune tolerance, autoantibody production, immune complex deposition, and complement activation, resulting in widespread inflammation and organ damage. Renal involvement, known as lupus nephritis (LN), occurs in approximately 40-60% of SLE patients and represents one of the most severe disease manifestations, significantly contributing to morbidity and mortality.Lupus nephritis arises from immune complex deposition in glomerular and tubulointerstitial structures, causing inflammatory and proliferative lesions that can progress to chronic kidney disease or end-stage renal disease. The ISN\u002FRPS classification provides a standardized histopathological framework essential for prognosis and guiding treatment decisions.\n\nIn addition to renal complications, patients with SLE and LN are at substantially increased risk of premature cardiovascular disease, which cannot be fully explained by traditional cardiovascular risk factors.Persistent systemic inflammation, endothelial dysfunction, dyslipidemia, and insulin resistance accelerate atherosclerosis in these patients. Subclinical vascular changes, including increased carotid intima-media thickness (CIMT) and carotid plaque formation, often precede overt cardiovascular events, underscoring the importance of early cardiovascular risk assessment The triglyceride-glucose (TyG) index is a validated surrogate marker of insulin resistance, correlating with endothelial dysfunction, subclinical atherosclerosis, and increased CIMT Elevated TyG index may therefore serve as a simple, non-invasive tool for early cardiovascular risk stratification in patients with lupus nephritis",[54,55],"Systemic Lupus Erthematosus (SLE)","Lupus Nephritis (LN)",[57,58,59],"triglyceride-glucose index","subclinical atherosclerosis","cardiovascular risk","NOT_YET_RECRUITING","2026-07-18",{"date":63,"type":64},"2026-07-22","ACTUAL",{"date":66,"type":50},"2026-07",{"date":68,"type":50},"2029-07",{"name":5,"class":6},1]