[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654172":3},{"organization":4,"outcomesModule":7,"designInfo":16,"detailedDescription":11,"studyPopulation":19,"armGroups":11,"interventions":11,"overallOfficials":11,"centralContacts":20,"locations":26,"responsibleParty":46,"collaborators":11,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":11,"eligibilityCriteria":55,"healthyVolunteers":52,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":11,"briefSummary":64,"conditions":65,"keywords":11,"overallStatus":29,"whyStopped":11,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"The Cleveland Clinic","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"To demonstrate the ability to quantify ophthalmic artery stenosis using a commercially available, non-invasive imaging modality, PC-CTA.",null,"From enrollment to the end of the 12-month study period.",[14],{"measure":15,"description":11,"timeFrame":12},"To provide compelling evidence for a connection between ophthalmic artery stenosis and OCT markers of dry AMD disease severity and progression.",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":17,"timePerspective":18,"maskingInfo":11},"COHORT","PROSPECTIVE","This prospective study will enroll 30 patients from 50-80 years of age with geographic atrophy in one eye and mild to moderate AMD in the fellow eye according to International Classification of Disease (ICD) codes treated at the Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.",[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Sara Lautzenhiser Research Coordinator","CONTACT","216-444-3026","LAUTZES@ccf.org",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Cleveland Clinic","RECRUITING","Cleveland","Ohio","44195","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-81.69541,41.4995,{"lat":39,"lon":38},[42,43],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},{"name":44,"role":45,"phone":11,"phoneExt":11,"email":11},"Scott Raymond, MD","PRINCIPAL_INVESTIGATOR",{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Scott Raymond","Staff Physician, Neurointerventional Radiologist","100654172","noninvasive-imaging-biomarkers-of-treatable-macrovascular-disease-in-age-related-macular-degeneration-100654172",false,"NCT07798323","Noninvasive Imaging Biomarkers of Treatable Macrovascular Disease in Age-related Macular Degeneration.","Inclusion Criteria:\n\n* 50-80 years of age\n* All genders\n* Asymmetric dry AMD with geographic atrophy in at least one eye and reduced disease severity in the other eye according to International Classification of Disease (ICD) codes\n* Treated at the Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio\n\nExclusion Criteria:\n\n* Poor image quality that limits quantification\n* GA extending beyond the borders of the SDOCT field of view.\n* Bilateral symmetric geographic atrophy.\n* Diagnosis of wet AMD.\n* Any retinal fluid at baseline.\n* Other concurrent retinal diseases\n* Vitreoretinal surgery.\n* Allergy to iodinated contrast agents.\n* Chronic kidney disease with eGFR \\\u003C 60","ALL","50 Years","80 Years",{"count":60,"type":61},30,"ESTIMATED","1 Year","OBSERVATIONAL","The purpose of this prospective study is to investigate whether ophthalmic artery stenosis (narrowing of the ophthalmic artery) contributes to the development and progression of geographic atrophy (GA), an advanced form of dry age-related macular degeneration (AMD).",[66],"Macular Degeneration","2026-09-02",{"date":69,"type":70},"2026-09-03","ACTUAL",{"date":72,"type":70},"2026-09-01",{"date":74,"type":61},"2028-12",{"name":48,"class":6},1]