[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561376":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":44,"responsibleParty":62,"collaborators":26,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":26,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":26,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Shirley Ryan AbilityLab","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Transcutaneous auricular vagus nerve stimulation","ACTIVE_COMPARATOR","Active vagus nerve stimulation.",[13],"Device: Transcutaneous auricular vagus active nerve stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Transcutaneous auricular vagus nerve stimulation","SHAM_COMPARATOR","Sham vagus nerve stimulation.",[19],"Device: Transcutaneous auricular vagus sham nerve stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcutaneous auricular vagus active nerve stimulation","In the active stimulation, two electrodes are placed in the cymba conchae of one of the ears, an area thought to be exclusively innervated by the auricular branch of the vagus nerve.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Transcutaneous auricular vagus sham nerve stimulation","In the sham stimulation, the electrodes are placed on the tail of helix, which is free of vagal innervation.",[15],[32],{"name":33,"affiliation":5,"role":34},"Shira Cohen-Zimerman, PhD","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","3122386450","sohenzime@sralab.org",{"name":41,"role":37,"phone":42,"phoneExt":26,"email":43},"Katy Magee, M.H.S","3122386451","kmagee02@sralab.org",[45],{"facility":5,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Chicago","Illinois","60610","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-87.65005,41.85003,{"lat":56,"lon":55},[59],{"name":60,"role":37,"phone":61,"phoneExt":26,"email":43},"Katy Magee, M.H.S. SLP","312-238-6451",{"type":34,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Shira Cohen-Zimerman","Research Scientist, PhD","100561376","noninvasive-vagal-nerve-stimulation-and-cognitive-rehabilitation-100561376",false,"NCT06589362","Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation","Enhancing Cognitive Rehabilitation After TBI Using Noninvasive Vagal Nerve Stimulation","Inclusion Criteria:\n\nIn inpatient rehabilitation due to recent Traumatic Brain Injury, ages 18-65 years.\n\nAbility to independently use a keyboard. Able to understand and communicate in English (according to clinical judgment). Able to independently provide consent to participate. Orientation to place, time, and situation (two consecutive scores of 25 or more on the Orientation Log(O-Log)40. This scale is routinely administered during acute rehabilitation stay.\n\nExclusion criteria:\n\nAcute medical issues requiring close physician or nursing monitoring. Bioelectrical implants, including pacemakers. Pregnancy or persons who are lactating. Significant gross or fine motor weakness. Significant, ongoing communication or comprehension impairments (such as aphasia) that would affect an individual's ability to complete the required assessments.\n\nAcute agitation or behavioral issues, as defined by a last Agitated Behavior Scale Score greater than 21 (routinely administered during acute rehabilitation stay, that would affect an individual's ability to participate in the required assessments.\n\nSeverely impaired memory retention (Score lower than 3 in the 3 Word Delayed Recall test, routinely administered during acute rehabilitation stay.\n\nDiagnosis of depression. Active substance abuse.","ALL","18 Years","65 Years",{"count":76,"type":77},60,"ESTIMATED","INTERVENTIONAL",[80],"NA","The purpose of this study is to examine the feasibility and preliminary efficacy of using transcutaneous auricular vagus nerve stimulation (tVNS) to enhance cognitive recovery in patients with mild-moderate traumatic brain injury (TBI).",[83],"Traumatic Brain Injury","2025-03-20",{"date":86,"type":87},"2025-03-25","ACTUAL",{"date":89,"type":87},"2024-09-07",{"date":91,"type":77},"2026-08",{"name":5,"class":6},1]