[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657951":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":26,"studyPopulation":20,"armGroups":27,"interventions":33,"overallOfficials":20,"centralContacts":38,"locations":44,"responsibleParty":57,"collaborators":20,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":20,"studyType":72,"phases":73,"briefSummary":74,"conditions":75,"keywords":20,"overallStatus":80,"whyStopped":20,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Centre Hospitalier Emile Roux","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"ad libitum food intake in response to exercise","Method: Meta-Max Indirect Calorimetry\n\nThe following will be measured here: energy expenditure in kcal\u002Fmin based on oxygen consumption, as well as fat and carbohydrate utilization based on the respiratory quotient (VCO2\u002FVO2), in mg\u002Fmin.","3 months",[14,17],{"measure":15,"description":16,"timeFrame":12},"Feelings of hunger in response to exercise","Method: HUNGER SENSATION QUESTIONNAIRE\n\nPatients will have to answer 4 questions with answer situated in between \"not at all\" and \"Very much\". The questions are: Are you hungry? Do you feel satiated? How much could you eat again? Would you like to eat something?",{"measure":18,"description":19,"timeFrame":12},"Hedonic response as measured by food liking and wanting","Their relationship with food will be investigated 15 min before the test meal and then 1 hour after, using the Leeds Foods Preference Questionnaire. The adolescents will be asked to answer a series of questions about their food preferences by selecting their favorite foods from a selection of images during a 10-min computer exercise. During this exercise, they are asked to use a visual analog scale to estimate how much they would like to eat certain foods presented. Based on their choices and the time taken to respond, the LFPQ assesses the adolescents' degree of \"liking\" and \"wanting.\" The adolescents will be asked to complete this exercise 15 minutes before and after the evening test meal. To avoid influencing food intake at the next meal, the foods presented during the test are not the same as those presented during the meal. As the aim of this exercise is to assess the response of \"liking\" and \"wanting\" to food intake, it is necessary to carry it out before and after the meal.",null,{"allocation":22,"interventionModel":23,"interventionModelDescription":20,"primaryPurpose":6,"observationalModel":20,"timePerspective":20,"maskingInfo":24},"NA","SINGLE_GROUP",{"masking":25,"maskingDescription":20,"whoMasked":20},"NONE","Our team has indeed demonstrated the appetite-suppressing effects of moderate- to vigorous-intensity exercise (\\>65% of maximum capacity) in obese adolescents, regardless of gender. While research conducted to date has primarily focused on identifying the characteristics of exercise that can influence food intake in these adolescents-such as the type, intensity, or duration of exercise-it appears that, beyond physical exercise itself, the energy substrates utilized during exercise may play a crucial role.\n\nIn adults-whether of normal weight, overweight, or obese-the scientific literature highlights not only the energy expenditure generated by physical exercise but also the vital role played by the type of energy substrate used to fuel this expenditure. Indeed, while physical exercise that primarily promotes lipid oxidation does not appear to significantly impact eating behavior at the next meal, carbohydrate utilization, on the other hand, appears to have a rather appetite-stimulating effect. Although this nutritional impact of the types of energy substrates utilized during physical exercise is crucial for better guiding our recommendations for adapted physical activity, it remains unexplored in adolescents at this time. Recently, based on a secondary analysis, our team suggested a positive correlation between energy expenditure during a 30-minute cycling exercise and subsequent food intake in adolescents with obesity. In that study, carbohydrate oxidation in particular showed a positive relationship with the adolescents' food intake at the next meal. These preliminary results led to a study dedicated to this question; however, that study unfortunately did not replicate this relationship and appears to indicate that carbohydrate utilization during acute exercise is not involved in short-term dietary regulation in these adolescents.\n\nHowever, that study had focused its design on an exercise regimen that promotes carbohydrate utilization, and the potential role of fat oxidation remains unexplored in this population. In overweight adults, Javernaud and colleagues previously demonstrated that exercise targeting the maximum lipid oxidation point (known as Lipoxmax) reduced feelings of hunger in the hours following the workout while improving participants' satiety. While prescribing physical exercise as a key component of pediatric obesity management is considered essential for optimizing treatment outcomes, the potential impact of exercise performed at Lipoxmax on food intake remains unexplored in this population.\n\nThus, in this context, the objective of this study is to explore the effects of a single session of exercise performed at the maximum lipid oxidation point (Lipoxmax) on dietary control in adolescents with obesity.",[28],{"label":29,"type":6,"description":30,"interventionNames":31},"Intervention","The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts).",[32],"Other: The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts)",[34],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":20},"The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts)","This study aims to understand how physical exercise performed at a specific intensity that promotes fat utilization (called LipoxMax) influences food intake, hunger, and food preferences in adolescents with obesity. Following an initial screening visit to verify eligibility criteria and assess dietary habits, participants undergo a measurement visit at Clermont-Ferrand University Hospital, which includes anthropometric assessments (height, weight, waist and hip circumferences), body composition measurements (body fat, muscle mass, bone structure), and a bicycle ergometer test to determine their LipoxMax intensity. The adolescents then undergo two experimental visits at the AME2P laboratory in Clermont-Ferrand, conducted in random order and spaced at least five days apart. At each visit, they arrive having fasted, consume a standardized breakfast, and then rest until 11:00 a.m. They then either rest for 40 minutes (control condition) or perform a 40-minute exercise session at LipoxMax.",[29],[39],{"name":40,"role":41,"phone":42,"phoneExt":20,"email":43},"David THIVEL","CONTACT","00 33 4 73405486","david.thivel@uca.fr",[45],{"facility":46,"status":20,"city":47,"state":20,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":20},"Laboratoire AME2P","Aubière","63178","France","FR",{"type":52,"coordinates":53},"Point",[54,55],3.11078,45.75082,{"lat":55,"lon":54},{"type":58,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100657951","nutritional-responses-to-acute-exercise-performed-on-the-lipoxmax-in-obese-adolescents-100657951",false,"NCT07844330","Nutritional Responses to Acute Exercise Performed on the LipoxMax in Obese Adolescents","LipoxAPP","Inclusion Criteria:\n\n* Adolescents aged 12 to 16 (inclusive), at Tanner stage 3-5,\n* With obesity defined as a body mass index (BMI) above the 95th percentile according to international growth charts,\n* Adolescents enrolled in the social security system or an equivalent program,\n* Adolescents who have been informed and have provided written consent to participate in the study\n\nExclusion Criteria:\n\n* Refusal to participate in the study,\n* Refusal of consent by legal guardians,\n* Regular use of tobacco or alcohol,\n* Special dietary restrictions,\n* Participation in regular and intense physical and sports activities,\n* Medical or surgical history deemed by the investigator to be incompatible with the study,\n* Diabetes, or any other condition that limits the application of either strategy in the trial,\n* Adolescents currently following a calorie-restricted diet or a weight-loss program involving physical activity at the time of enrollment or within the past 6 months,\n* Taking medications that may interfere with the study results,\n* Adolescents with cardiovascular problems; this refers to participants with a history of cardiovascular and\u002For neurovascular disease, as well as those with cardiovascular and\u002For neurovascular risk factors (excluding obesity or being overweight),\n* Surgery within the previous 3 months,\n* Adolescents who are currently excluded from another study,\n* Pregnant or breastfeeding adolescents,\n* Adolescents under guardianship, conservatorship, or judicial protection,\n* Parents under conservatorship, guardianship, or judicial protection","ALL","12 Years","16 Years",{"count":70,"type":71},18,"ESTIMATED","INTERVENTIONAL",[22],"Primarily over the past 20 years, it has been shown that physical activity not only leads to energy expenditure but can also indirectly influence energy intake and feelings of hunger in both lean and obese adults, suggesting that physical activity has a dual effect on energy balance.\n\nStudies in children and adolescents are less common, but it now seems clear that their energy intake is affected by physical exercise ) depending on their weight status.",[76,77,78,79],"Weight Gain","Weight Loss","Eating Attitudes","Obese Adolescents","NOT_YET_RECRUITING","2026-09-22",{"date":83,"type":84},"2026-09-28","ACTUAL",{"date":86,"type":71},"2026-09-01",{"date":88,"type":71},"2029-09-30",{"name":5,"class":6},1]