[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535509":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":10,"centralContacts":49,"locations":55,"responsibleParty":1396,"collaborators":1398,"id":1401,"slug":1402,"hasResults":1403,"nctId":1404,"briefTitle":1405,"officialTitle":1406,"acronym":1407,"eligibilityCriteria":1408,"healthyVolunteers":1403,"sex":1409,"minAge":1410,"maxAge":1411,"enrollmentInfo":1412,"targetDuration":10,"studyType":1415,"phases":10,"briefSummary":1416,"conditions":1417,"keywords":1419,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":1427,"lastUpdatePostDateStruct":1428,"startDateStruct":1431,"completionDateStruct":1433,"leadSponsor":1435,"locationsCount":1436},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8,14,18,23],{"label":9,"type":10,"description":11,"interventionNames":12},"unresectable hepatocellular carcinoma (uHCC)",null,"advanced uHCC patients who had not received prior systemic therapy and were not eligible for LRT, as well as those who had progressed following LRT, and who have received a durvalumab-based regimen",[13],"Other: Durvalumab-based combination therapies in observational study setting",{"label":15,"type":10,"description":16,"interventionNames":17},"advanced biliary tract cancer (aBTC)","patients with advanced BTC (aBTC) who are not eligible for resection and who have received a durvalumab-based regimen",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"eeHCC","uHCC patients with liver-confined disease not amenable to curative treatment but amenable to LRT who receive LRT alone or LRT followed by systemic therapy within 60 days (if administered in combination, LRT must be received first)",[22],"Other: Non Durvalumab-based therapies in observational study setting",{"label":24,"type":10,"description":25,"interventionNames":26},"EMERALD","uHCC patients with liver-confined disease not amenable to curative treatment but amenable to LRT who receive durvalumab-based regimens in combination with LRT (durvalumab and LRT are given within 28 days of each other, regardless of order)",[27],"Other: Durvalumab-based combination therapies in observational study settings",[29,36,40,44],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"OTHER","Durvalumab-based combination therapies in observational study setting","Data on patients who initiated durvalumab-based regimens, including STRIDE (Single Tremelimumab Regular Interval Durvalumab), will be collected).",[9],[35],"Imfinzi",{"type":30,"name":31,"description":37,"armGroupLabels":38,"otherNames":39},"Data on patients who initiated durvalumab-based regimens, including durvalumab + chemotherapy combinations (e.g., Durvalumab + GemCis etc.) will be collected.",[15],[35],{"type":30,"name":41,"description":42,"armGroupLabels":43,"otherNames":10},"Non Durvalumab-based therapies in observational study setting","Data on patients who initiated non durvalumab-based regimens, including LRT alone or LRT followed by systemic therapies, will be collected.",[19],{"type":30,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"Durvalumab-based combination therapies in observational study settings","Data on patients who initiated durvalumab-based regimens in combination with LRT, will be collected",[24],[35],[50],{"name":51,"role":52,"phone":53,"phoneExt":10,"email":54},"AstraZeneca Clinical Study Information Center","CONTACT","1-877-240-9479","information.center@astrazeneca.com",[56,70,78,87,96,104,112,121,129,137,146,155,163,172,181,190,199,208,217,225,233,241,250,258,267,278,287,295,304,315,324,333,344,353,361,370,379,388,399,402,411,420,427,432,443,451,460,469,480,489,498,507,516,525,534,542,551,556,567,576,584,593,601,611,619,623,632,640,649,658,666,671,680,689,697,705,713,721,729,738,747,755,763,772,780,789,797,802,810,815,826,834,839,848,853,862,873,882,890,897,908,917,922,931,939,944,952,961,970,979,990,994,1003,1012,1021,1029,1038,1047,1058,1067,1078,1086,1094,1099,1110,1120,1128,1136,1144,1155,1164,1173,1178,1189,1198,1207,1216,1220,1229,1238,1247,1255,1262,1267,1272,1277,1285,1293,1301,1309,1317,1328,1336,1347,1355,1363,1368,1376,1387],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":10},"Research Site","RECRUITING","Birmingham","Alabama","35233-1932","United States","US",{"type":65,"coordinates":66},"Point",[67,68],-86.80249,33.52066,{"lat":68,"lon":67},{"facility":57,"status":58,"city":71,"state":60,"zip":72,"country":62,"countryCode":63,"cosmosGeoPoint":73,"geoPoint":77,"contacts":10},"Mobile","36604",{"type":65,"coordinates":74},[75,76],-88.04305,30.69436,{"lat":76,"lon":75},{"facility":57,"status":58,"city":79,"state":80,"zip":81,"country":62,"countryCode":63,"cosmosGeoPoint":82,"geoPoint":86,"contacts":10},"Phoenix","Arizona","85004",{"type":65,"coordinates":83},[84,85],-112.07404,33.44838,{"lat":85,"lon":84},{"facility":57,"status":58,"city":88,"state":89,"zip":90,"country":62,"countryCode":63,"cosmosGeoPoint":91,"geoPoint":95,"contacts":10},"Coronado","California","92118",{"type":65,"coordinates":92},[93,94],-117.18309,32.68589,{"lat":94,"lon":93},{"facility":57,"status":58,"city":97,"state":89,"zip":98,"country":62,"countryCode":63,"cosmosGeoPoint":99,"geoPoint":103,"contacts":10},"Los Angeles","90048",{"type":65,"coordinates":100},[101,102],-118.24368,34.05223,{"lat":102,"lon":101},{"facility":57,"status":58,"city":105,"state":89,"zip":106,"country":62,"countryCode":63,"cosmosGeoPoint":107,"geoPoint":111,"contacts":10},"Walnut Creek","94598",{"type":65,"coordinates":108},[109,110],-122.06496,37.90631,{"lat":110,"lon":109},{"facility":57,"status":58,"city":113,"state":114,"zip":115,"country":62,"countryCode":63,"cosmosGeoPoint":116,"geoPoint":120,"contacts":10},"Clermont","Florida","34711",{"type":65,"coordinates":117},[118,119],-81.77285,28.54944,{"lat":119,"lon":118},{"facility":57,"status":58,"city":122,"state":114,"zip":123,"country":62,"countryCode":63,"cosmosGeoPoint":124,"geoPoint":128,"contacts":10},"Gainesville","32610",{"type":65,"coordinates":125},[126,127],-82.32483,29.65163,{"lat":127,"lon":126},{"facility":57,"status":58,"city":130,"state":114,"zip":131,"country":62,"countryCode":63,"cosmosGeoPoint":132,"geoPoint":136,"contacts":10},"Tampa","33606",{"type":65,"coordinates":133},[134,135],-82.45843,27.94752,{"lat":135,"lon":134},{"facility":57,"status":58,"city":138,"state":139,"zip":140,"country":62,"countryCode":63,"cosmosGeoPoint":141,"geoPoint":145,"contacts":10},"Augusta","Georgia","30912",{"type":65,"coordinates":142},[143,144],-81.97484,33.47097,{"lat":144,"lon":143},{"facility":57,"status":58,"city":147,"state":148,"zip":149,"country":62,"countryCode":63,"cosmosGeoPoint":150,"geoPoint":154,"contacts":10},"Evergreen Park","Illinois","60805",{"type":65,"coordinates":151},[152,153],-87.70172,41.72059,{"lat":153,"lon":152},{"facility":57,"status":58,"city":156,"state":148,"zip":157,"country":62,"countryCode":63,"cosmosGeoPoint":158,"geoPoint":162,"contacts":10},"Hinsdale","60521",{"type":65,"coordinates":159},[160,161],-87.93701,41.80086,{"lat":161,"lon":160},{"facility":57,"status":58,"city":164,"state":165,"zip":166,"country":62,"countryCode":63,"cosmosGeoPoint":167,"geoPoint":171,"contacts":10},"Baton Rouge","Louisiana","70808",{"type":65,"coordinates":168},[169,170],-91.18747,30.44332,{"lat":170,"lon":169},{"facility":57,"status":58,"city":173,"state":174,"zip":175,"country":62,"countryCode":63,"cosmosGeoPoint":176,"geoPoint":180,"contacts":10},"Boston","Massachusetts","02215",{"type":65,"coordinates":177},[178,179],-71.05977,42.35843,{"lat":179,"lon":178},{"facility":57,"status":58,"city":182,"state":183,"zip":184,"country":62,"countryCode":63,"cosmosGeoPoint":185,"geoPoint":189,"contacts":10},"Osage Beach","Missouri","65065",{"type":65,"coordinates":186},[187,188],-92.65277,38.12956,{"lat":188,"lon":187},{"facility":57,"status":58,"city":191,"state":192,"zip":193,"country":62,"countryCode":63,"cosmosGeoPoint":194,"geoPoint":198,"contacts":10},"White Plains","New York","10601",{"type":65,"coordinates":195},[196,197],-73.76291,41.03399,{"lat":197,"lon":196},{"facility":57,"status":58,"city":200,"state":201,"zip":202,"country":62,"countryCode":63,"cosmosGeoPoint":203,"geoPoint":207,"contacts":10},"Canton","Ohio","44718",{"type":65,"coordinates":204},[205,206],-81.37845,40.79895,{"lat":206,"lon":205},{"facility":57,"status":58,"city":209,"state":210,"zip":211,"country":62,"countryCode":63,"cosmosGeoPoint":212,"geoPoint":216,"contacts":10},"Bethlehem","Pennsylvania","18015",{"type":65,"coordinates":213},[214,215],-75.37046,40.62593,{"lat":215,"lon":214},{"facility":57,"status":58,"city":218,"state":210,"zip":219,"country":62,"countryCode":63,"cosmosGeoPoint":220,"geoPoint":224,"contacts":10},"Lancaster","17604",{"type":65,"coordinates":221},[222,223],-76.30551,40.03788,{"lat":223,"lon":222},{"facility":57,"status":58,"city":226,"state":210,"zip":227,"country":62,"countryCode":63,"cosmosGeoPoint":228,"geoPoint":232,"contacts":10},"Philadelphia","19141",{"type":65,"coordinates":229},[230,231],-75.16362,39.95238,{"lat":231,"lon":230},{"facility":57,"status":58,"city":234,"state":210,"zip":235,"country":62,"countryCode":63,"cosmosGeoPoint":236,"geoPoint":240,"contacts":10},"Pittsburgh","15212",{"type":65,"coordinates":237},[238,239],-79.99589,40.44062,{"lat":239,"lon":238},{"facility":57,"status":58,"city":242,"state":243,"zip":244,"country":62,"countryCode":63,"cosmosGeoPoint":245,"geoPoint":249,"contacts":10},"Dallas","Texas","75390-8567",{"type":65,"coordinates":246},[247,248],-96.80667,32.78306,{"lat":248,"lon":247},{"facility":57,"status":58,"city":251,"state":243,"zip":252,"country":62,"countryCode":63,"cosmosGeoPoint":253,"geoPoint":257,"contacts":10},"Temple","76508",{"type":65,"coordinates":254},[255,256],-97.34278,31.09823,{"lat":256,"lon":255},{"facility":57,"status":58,"city":259,"state":260,"zip":261,"country":62,"countryCode":63,"cosmosGeoPoint":262,"geoPoint":266,"contacts":10},"Spokane","Washington","99204",{"type":65,"coordinates":263},[264,265],-117.42908,47.65966,{"lat":265,"lon":264},{"facility":57,"status":58,"city":268,"state":269,"zip":270,"country":271,"countryCode":272,"cosmosGeoPoint":273,"geoPoint":277,"contacts":10},"Garran","Australian Capital Territory","2605","Australia","AU",{"type":65,"coordinates":274},[275,276],149.10846,-35.34206,{"lat":276,"lon":275},{"facility":57,"status":58,"city":279,"state":280,"zip":281,"country":271,"countryCode":272,"cosmosGeoPoint":282,"geoPoint":286,"contacts":10},"Heidelberg","Victoria","3084",{"type":65,"coordinates":283},[284,285],145.06667,-37.75,{"lat":285,"lon":284},{"facility":57,"status":58,"city":288,"state":280,"zip":289,"country":271,"countryCode":272,"cosmosGeoPoint":290,"geoPoint":294,"contacts":10},"Melbourne","3004",{"type":65,"coordinates":291},[292,293],144.96332,-37.814,{"lat":293,"lon":292},{"facility":57,"status":58,"city":296,"state":297,"zip":298,"country":271,"countryCode":272,"cosmosGeoPoint":299,"geoPoint":303,"contacts":10},"Murdoch","Western Australia","6150",{"type":65,"coordinates":300},[301,302],115.83757,-32.06987,{"lat":302,"lon":301},{"facility":57,"status":58,"city":305,"state":306,"zip":307,"country":308,"countryCode":309,"cosmosGeoPoint":310,"geoPoint":314,"contacts":10},"Sankt Pölten","Lower Austria","3100","Austria","AT",{"type":65,"coordinates":311},[312,313],15.63725,48.20762,{"lat":313,"lon":312},{"facility":57,"status":58,"city":316,"state":317,"zip":318,"country":308,"countryCode":309,"cosmosGeoPoint":319,"geoPoint":323,"contacts":10},"Vienna","State of Vienna","1090",{"type":65,"coordinates":320},[321,322],16.37208,48.20849,{"lat":322,"lon":321},{"facility":57,"status":58,"city":325,"state":326,"zip":327,"country":308,"countryCode":309,"cosmosGeoPoint":328,"geoPoint":332,"contacts":10},"Linz","Upper Austria","4010",{"type":65,"coordinates":329},[330,331],14.28611,48.30639,{"lat":331,"lon":330},{"facility":57,"status":58,"city":334,"state":335,"zip":336,"country":337,"countryCode":338,"cosmosGeoPoint":339,"geoPoint":343,"contacts":10},"Brussels","Anderlecht","1070","Belgium","BE",{"type":65,"coordinates":340},[341,342],4.34878,50.85045,{"lat":342,"lon":341},{"facility":57,"status":58,"city":345,"state":346,"zip":347,"country":337,"countryCode":338,"cosmosGeoPoint":348,"geoPoint":352,"contacts":10},"Bonheiden","Antwerp","2820",{"type":65,"coordinates":349},[350,351],4.54714,51.02261,{"lat":351,"lon":350},{"facility":57,"status":58,"city":354,"state":346,"zip":355,"country":337,"countryCode":338,"cosmosGeoPoint":356,"geoPoint":360,"contacts":10},"Edegem","2650",{"type":65,"coordinates":357},[358,359],4.44504,51.15662,{"lat":359,"lon":358},{"facility":57,"status":58,"city":362,"state":363,"zip":364,"country":337,"countryCode":338,"cosmosGeoPoint":365,"geoPoint":369,"contacts":10},"Leuven","Brabant","3000",{"type":65,"coordinates":366},[367,368],4.70093,50.87959,{"lat":368,"lon":367},{"facility":57,"status":58,"city":371,"state":372,"zip":373,"country":337,"countryCode":338,"cosmosGeoPoint":374,"geoPoint":378,"contacts":10},"Liège","Wallonia","4000",{"type":65,"coordinates":375},[376,377],5.56749,50.63373,{"lat":377,"lon":376},{"facility":57,"status":58,"city":380,"state":381,"zip":382,"country":337,"countryCode":338,"cosmosGeoPoint":383,"geoPoint":387,"contacts":10},"Stene","West Flanders","8400",{"type":65,"coordinates":384},[385,386],2.91259,51.20437,{"lat":386,"lon":385},{"facility":57,"status":58,"city":389,"state":390,"zip":391,"country":392,"countryCode":393,"cosmosGeoPoint":394,"geoPoint":398,"contacts":10},"Curitiba","Paraná","81480-580","Brazil","BR",{"type":65,"coordinates":395},[396,397],-49.27306,-25.42778,{"lat":397,"lon":396},{"facility":57,"status":58,"city":400,"state":400,"zip":401,"country":392,"countryCode":393,"cosmosGeoPoint":10,"geoPoint":10,"contacts":10},"Recife - PE","50070-490",{"facility":57,"status":58,"city":403,"state":404,"zip":405,"country":392,"countryCode":393,"cosmosGeoPoint":406,"geoPoint":410,"contacts":10},"Porto Alegre","Rio Grande do Sul","90035-001",{"type":65,"coordinates":407},[408,409],-51.23019,-30.03283,{"lat":409,"lon":408},{"facility":57,"status":58,"city":412,"state":413,"zip":414,"country":392,"countryCode":393,"cosmosGeoPoint":415,"geoPoint":419,"contacts":10},"Morumbi","São Paulo","05651-901",{"type":65,"coordinates":416},[417,418],-46.70802,-23.59632,{"lat":418,"lon":417},{"facility":57,"status":58,"city":413,"state":10,"zip":421,"country":392,"countryCode":393,"cosmosGeoPoint":422,"geoPoint":426,"contacts":10},"01246-000",{"type":65,"coordinates":423},[424,425],-46.63611,-23.5475,{"lat":425,"lon":424},{"facility":57,"status":58,"city":413,"state":10,"zip":428,"country":392,"countryCode":393,"cosmosGeoPoint":429,"geoPoint":431,"contacts":10},"04538-132",{"type":65,"coordinates":430},[424,425],{"lat":425,"lon":424},{"facility":57,"status":58,"city":433,"state":434,"zip":435,"country":436,"countryCode":437,"cosmosGeoPoint":438,"geoPoint":442,"contacts":10},"Calgary","Alberta","T2N 4N2","Canada","CA",{"type":65,"coordinates":439},[440,441],-114.08529,51.05011,{"lat":441,"lon":440},{"facility":57,"status":58,"city":444,"state":434,"zip":445,"country":436,"countryCode":437,"cosmosGeoPoint":446,"geoPoint":450,"contacts":10},"Edmonton","T6G-1Z2",{"type":65,"coordinates":447},[448,449],-113.46871,53.55014,{"lat":449,"lon":448},{"facility":57,"status":58,"city":452,"state":453,"zip":454,"country":436,"countryCode":437,"cosmosGeoPoint":455,"geoPoint":459,"contacts":10},"Halifax","Nova Scotia","B3H 2Y9",{"type":65,"coordinates":456},[457,458],-63.57688,44.64269,{"lat":458,"lon":457},{"facility":57,"status":58,"city":461,"state":462,"zip":463,"country":436,"countryCode":437,"cosmosGeoPoint":464,"geoPoint":468,"contacts":10},"London","Ontario","N6A 5W9",{"type":65,"coordinates":465},[466,467],-81.23304,42.98339,{"lat":467,"lon":466},{"facility":57,"status":58,"city":470,"state":471,"zip":472,"country":473,"countryCode":474,"cosmosGeoPoint":475,"geoPoint":479,"contacts":10},"Strasbourg","Alsace","67000","France","FR",{"type":65,"coordinates":476},[477,478],7.74553,48.58392,{"lat":478,"lon":477},{"facility":57,"status":58,"city":481,"state":482,"zip":483,"country":473,"countryCode":474,"cosmosGeoPoint":484,"geoPoint":488,"contacts":10},"Grenoble","Auvergne-Rh ne-Alpes","38700",{"type":65,"coordinates":485},[486,487],5.71479,45.17869,{"lat":487,"lon":486},{"facility":57,"status":58,"city":490,"state":491,"zip":492,"country":473,"countryCode":474,"cosmosGeoPoint":493,"geoPoint":497,"contacts":10},"St-Malo","Brittany Region","35403",{"type":65,"coordinates":494},[495,496],-2.00877,48.64738,{"lat":496,"lon":495},{"facility":57,"status":58,"city":499,"state":500,"zip":501,"country":473,"countryCode":474,"cosmosGeoPoint":502,"geoPoint":506,"contacts":10},"Mulhouse","Grand Est","68100",{"type":65,"coordinates":503},[504,505],7.32866,47.75205,{"lat":505,"lon":504},{"facility":57,"status":58,"city":508,"state":509,"zip":510,"country":473,"countryCode":474,"cosmosGeoPoint":511,"geoPoint":515,"contacts":10},"Boulogne-sur-Mer","Hauts-de-France","62200",{"type":65,"coordinates":512},[513,514],1.61373,50.72485,{"lat":514,"lon":513},{"facility":57,"status":58,"city":517,"state":518,"zip":519,"country":473,"countryCode":474,"cosmosGeoPoint":520,"geoPoint":524,"contacts":10},"Poitiers","New Aquitaine","86000",{"type":65,"coordinates":521},[522,523],0.34348,46.58261,{"lat":523,"lon":522},{"facility":57,"status":58,"city":526,"state":527,"zip":528,"country":473,"countryCode":474,"cosmosGeoPoint":529,"geoPoint":533,"contacts":10},"Avignon","Provence-Alpes-Côte d'Azur Region","84918",{"type":65,"coordinates":530},[531,532],4.80892,43.94834,{"lat":532,"lon":531},{"facility":57,"status":58,"city":535,"state":527,"zip":536,"country":473,"countryCode":474,"cosmosGeoPoint":537,"geoPoint":541,"contacts":10},"Marseille","13008",{"type":65,"coordinates":538},[539,540],5.38107,43.29695,{"lat":540,"lon":539},{"facility":57,"status":58,"city":543,"state":544,"zip":545,"country":473,"countryCode":474,"cosmosGeoPoint":546,"geoPoint":550,"contacts":10},"Paris","Île-de-France Region","75012",{"type":65,"coordinates":547},[548,549],2.3488,48.85341,{"lat":549,"lon":548},{"facility":57,"status":58,"city":543,"state":544,"zip":552,"country":473,"countryCode":474,"cosmosGeoPoint":553,"geoPoint":555,"contacts":10},"75014",{"type":65,"coordinates":554},[548,549],{"lat":549,"lon":548},{"facility":57,"status":58,"city":557,"state":558,"zip":559,"country":560,"countryCode":561,"cosmosGeoPoint":562,"geoPoint":566,"contacts":10},"Heidenheim","Baden W Rttemberg","89522","Germany","DE",{"type":65,"coordinates":563},[564,565],10.15162,48.67798,{"lat":565,"lon":564},{"facility":57,"status":58,"city":568,"state":569,"zip":570,"country":560,"countryCode":561,"cosmosGeoPoint":571,"geoPoint":575,"contacts":10},"Konstanz","Baden-W Rttemberg","78484",{"type":65,"coordinates":572},[573,574],9.17582,47.66033,{"lat":574,"lon":573},{"facility":57,"status":58,"city":577,"state":569,"zip":578,"country":560,"countryCode":561,"cosmosGeoPoint":579,"geoPoint":583,"contacts":10},"Schorndorf","73614",{"type":65,"coordinates":580},[581,582],9.52721,48.80537,{"lat":582,"lon":581},{"facility":57,"status":58,"city":585,"state":586,"zip":587,"country":560,"countryCode":561,"cosmosGeoPoint":588,"geoPoint":592,"contacts":10},"Mannheim","Baden-Wurttemberg","68167",{"type":65,"coordinates":589},[590,591],8.46694,49.4891,{"lat":591,"lon":590},{"facility":57,"status":58,"city":594,"state":586,"zip":595,"country":560,"countryCode":561,"cosmosGeoPoint":596,"geoPoint":600,"contacts":10},"Stuttgart","70174",{"type":65,"coordinates":597},[598,599],9.17702,48.78232,{"lat":599,"lon":598},{"facility":57,"status":602,"city":603,"state":604,"zip":605,"country":560,"countryCode":561,"cosmosGeoPoint":606,"geoPoint":610,"contacts":10},"TERMINATED","Augsburg","Bavaria","86150",{"type":65,"coordinates":607},[608,609],10.89851,48.37154,{"lat":609,"lon":608},{"facility":57,"status":58,"city":612,"state":604,"zip":613,"country":560,"countryCode":561,"cosmosGeoPoint":614,"geoPoint":618,"contacts":10},"Munich","81377",{"type":65,"coordinates":615},[616,617],11.57549,48.13743,{"lat":617,"lon":616},{"facility":57,"status":58,"city":620,"state":621,"zip":622,"country":560,"countryCode":561,"cosmosGeoPoint":10,"geoPoint":10,"contacts":10},"Bremenhaven","Free Hanseatic City of Bremen","27574",{"facility":57,"status":58,"city":624,"state":625,"zip":626,"country":560,"countryCode":561,"cosmosGeoPoint":627,"geoPoint":631,"contacts":10},"Kassel","Hesse","34125",{"type":65,"coordinates":628},[629,630],9.5,51.31667,{"lat":630,"lon":629},{"facility":57,"status":58,"city":633,"state":625,"zip":634,"country":560,"countryCode":561,"cosmosGeoPoint":635,"geoPoint":639,"contacts":10},"Marburg","35033",{"type":65,"coordinates":636},[637,638],8.77069,50.80904,{"lat":638,"lon":637},{"facility":57,"status":58,"city":641,"state":642,"zip":643,"country":560,"countryCode":561,"cosmosGeoPoint":644,"geoPoint":648,"contacts":10},"Wiesbaden","Hesse Land","65189",{"type":65,"coordinates":645},[646,647],8.24435,50.08601,{"lat":647,"lon":646},{"facility":57,"status":58,"city":650,"state":651,"zip":652,"country":560,"countryCode":561,"cosmosGeoPoint":653,"geoPoint":657,"contacts":10},"Göttingen","Lower Saxony","37075",{"type":65,"coordinates":654},[655,656],9.93228,51.53443,{"lat":656,"lon":655},{"facility":57,"status":58,"city":659,"state":651,"zip":660,"country":560,"countryCode":561,"cosmosGeoPoint":661,"geoPoint":665,"contacts":10},"Hanover","30161",{"type":65,"coordinates":662},[663,664],9.73322,52.37052,{"lat":664,"lon":663},{"facility":57,"status":58,"city":659,"state":651,"zip":667,"country":560,"countryCode":561,"cosmosGeoPoint":668,"geoPoint":670,"contacts":10},"30459",{"type":65,"coordinates":669},[663,664],{"lat":664,"lon":663},{"facility":57,"status":58,"city":672,"state":673,"zip":674,"country":560,"countryCode":561,"cosmosGeoPoint":675,"geoPoint":679,"contacts":10},"Rostock","Mecklenburg-Vorpommern","18057",{"type":65,"coordinates":676},[677,678],12.14049,54.0887,{"lat":678,"lon":677},{"facility":57,"status":58,"city":681,"state":682,"zip":683,"country":560,"countryCode":561,"cosmosGeoPoint":684,"geoPoint":688,"contacts":10},"Aachen","North Rhine-Westphalia","52074",{"type":65,"coordinates":685},[686,687],6.08342,50.77664,{"lat":687,"lon":686},{"facility":57,"status":58,"city":690,"state":682,"zip":691,"country":560,"countryCode":561,"cosmosGeoPoint":692,"geoPoint":696,"contacts":10},"Bochum","44892",{"type":65,"coordinates":693},[694,695],7.21648,51.48165,{"lat":695,"lon":694},{"facility":57,"status":58,"city":698,"state":682,"zip":699,"country":560,"countryCode":561,"cosmosGeoPoint":700,"geoPoint":704,"contacts":10},"Cologne","50937",{"type":65,"coordinates":701},[702,703],6.95,50.93333,{"lat":703,"lon":702},{"facility":57,"status":58,"city":706,"state":682,"zip":707,"country":560,"countryCode":561,"cosmosGeoPoint":708,"geoPoint":712,"contacts":10},"Dortmund","44137",{"type":65,"coordinates":709},[710,711],7.466,51.51494,{"lat":711,"lon":710},{"facility":57,"status":58,"city":714,"state":682,"zip":715,"country":560,"countryCode":561,"cosmosGeoPoint":716,"geoPoint":720,"contacts":10},"Moers","47441",{"type":65,"coordinates":717},[718,719],6.6326,51.45342,{"lat":719,"lon":718},{"facility":57,"status":58,"city":722,"state":682,"zip":723,"country":560,"countryCode":561,"cosmosGeoPoint":724,"geoPoint":728,"contacts":10},"Stolberg","52222",{"type":65,"coordinates":725},[726,727],6.22595,50.77368,{"lat":727,"lon":726},{"facility":57,"status":58,"city":730,"state":731,"zip":732,"country":560,"countryCode":561,"cosmosGeoPoint":733,"geoPoint":737,"contacts":10},"Koblenz","Rhineland-Palatinate","56073",{"type":65,"coordinates":734},[735,736],7.57883,50.35357,{"lat":736,"lon":735},{"facility":57,"status":58,"city":739,"state":740,"zip":741,"country":560,"countryCode":561,"cosmosGeoPoint":742,"geoPoint":746,"contacts":10},"Dresden","Saxony","1307",{"type":65,"coordinates":743},[744,745],13.73832,51.05089,{"lat":745,"lon":744},{"facility":57,"status":58,"city":748,"state":740,"zip":749,"country":560,"countryCode":561,"cosmosGeoPoint":750,"geoPoint":754,"contacts":10},"Leipzig","4103",{"type":65,"coordinates":751},[752,753],12.37129,51.33962,{"lat":753,"lon":752},{"facility":57,"status":58,"city":756,"state":740,"zip":757,"country":560,"countryCode":561,"cosmosGeoPoint":758,"geoPoint":762,"contacts":10},"Zwickau","8060",{"type":65,"coordinates":759},[760,761],12.48839,50.72724,{"lat":761,"lon":760},{"facility":57,"status":58,"city":764,"state":765,"zip":766,"country":560,"countryCode":561,"cosmosGeoPoint":767,"geoPoint":771,"contacts":10},"Halle","Saxony-Anhalt","06108",{"type":65,"coordinates":768},[769,770],11.97947,51.48158,{"lat":770,"lon":769},{"facility":57,"status":58,"city":773,"state":765,"zip":774,"country":560,"countryCode":561,"cosmosGeoPoint":775,"geoPoint":779,"contacts":10},"Magdeburg","39120",{"type":65,"coordinates":776},[777,778],11.63189,52.13129,{"lat":778,"lon":777},{"facility":57,"status":58,"city":781,"state":782,"zip":783,"country":560,"countryCode":561,"cosmosGeoPoint":784,"geoPoint":788,"contacts":10},"Neumünster","Schleswig-Holstein","24534",{"type":65,"coordinates":785},[786,787],9.98456,54.07399,{"lat":787,"lon":786},{"facility":57,"status":58,"city":790,"state":10,"zip":791,"country":560,"countryCode":561,"cosmosGeoPoint":792,"geoPoint":796,"contacts":10},"Berlin","13353",{"type":65,"coordinates":793},[794,795],13.41053,52.52437,{"lat":795,"lon":794},{"facility":57,"status":58,"city":790,"state":10,"zip":798,"country":560,"countryCode":561,"cosmosGeoPoint":799,"geoPoint":801,"contacts":10},"14165",{"type":65,"coordinates":800},[794,795],{"lat":795,"lon":794},{"facility":57,"status":58,"city":803,"state":10,"zip":804,"country":560,"countryCode":561,"cosmosGeoPoint":805,"geoPoint":809,"contacts":10},"Hamburg","20259",{"type":65,"coordinates":806},[807,808],9.99302,53.55073,{"lat":808,"lon":807},{"facility":57,"status":58,"city":803,"state":10,"zip":811,"country":560,"countryCode":561,"cosmosGeoPoint":812,"geoPoint":814,"contacts":10},"22291",{"type":65,"coordinates":813},[807,808],{"lat":808,"lon":807},{"facility":57,"status":58,"city":816,"state":817,"zip":818,"country":819,"countryCode":820,"cosmosGeoPoint":821,"geoPoint":825,"contacts":10},"Chaïdári","Athens","12462","Greece","GR",{"type":65,"coordinates":822},[823,824],23.66597,38.01135,{"lat":824,"lon":823},{"facility":57,"status":58,"city":817,"state":827,"zip":828,"country":819,"countryCode":820,"cosmosGeoPoint":829,"geoPoint":833,"contacts":10},"Attica","11527",{"type":65,"coordinates":830},[831,832],23.72784,37.98376,{"lat":832,"lon":831},{"facility":57,"status":58,"city":817,"state":827,"zip":835,"country":819,"countryCode":820,"cosmosGeoPoint":836,"geoPoint":838,"contacts":10},"14564",{"type":65,"coordinates":837},[831,832],{"lat":832,"lon":831},{"facility":57,"status":58,"city":840,"state":841,"zip":842,"country":819,"countryCode":820,"cosmosGeoPoint":843,"geoPoint":847,"contacts":10},"Thessaloniki","Central Macedonia","54639",{"type":65,"coordinates":844},[845,846],22.93493,40.64072,{"lat":846,"lon":845},{"facility":57,"status":58,"city":840,"state":841,"zip":849,"country":819,"countryCode":820,"cosmosGeoPoint":850,"geoPoint":852,"contacts":10},"55236",{"type":65,"coordinates":851},[845,846],{"lat":846,"lon":845},{"facility":57,"status":58,"city":854,"state":855,"zip":856,"country":819,"countryCode":820,"cosmosGeoPoint":857,"geoPoint":861,"contacts":10},"Larissa","Thessaly","41110",{"type":65,"coordinates":858},[859,860],22.42112,39.62847,{"lat":860,"lon":859},{"facility":57,"status":58,"city":863,"state":864,"zip":865,"country":866,"countryCode":867,"cosmosGeoPoint":868,"geoPoint":872,"contacts":10},"Nahariya","Northern Didstrict","22100","Israel","IL",{"type":65,"coordinates":869},[870,871],35.09814,33.00892,{"lat":871,"lon":870},{"facility":57,"status":58,"city":874,"state":875,"zip":876,"country":866,"countryCode":867,"cosmosGeoPoint":877,"geoPoint":881,"contacts":10},"Ramat Gan","Tel Aviv","52621",{"type":65,"coordinates":878},[879,880],34.81065,32.08227,{"lat":880,"lon":879},{"facility":57,"status":58,"city":883,"state":10,"zip":884,"country":866,"countryCode":867,"cosmosGeoPoint":885,"geoPoint":889,"contacts":10},"Jerusalem","9103102",{"type":65,"coordinates":886},[887,888],35.21633,31.76904,{"lat":888,"lon":887},{"facility":57,"status":58,"city":875,"state":10,"zip":891,"country":866,"countryCode":867,"cosmosGeoPoint":892,"geoPoint":896,"contacts":10},"6423906",{"type":65,"coordinates":893},[894,895],34.78057,32.08088,{"lat":895,"lon":894},{"facility":57,"status":58,"city":898,"state":899,"zip":900,"country":901,"countryCode":902,"cosmosGeoPoint":903,"geoPoint":907,"contacts":10},"Naples","Campania","80131","Italy","IT",{"type":65,"coordinates":904},[905,906],14.26811,40.85216,{"lat":906,"lon":905},{"facility":57,"status":58,"city":909,"state":910,"zip":911,"country":901,"countryCode":902,"cosmosGeoPoint":912,"geoPoint":916,"contacts":10},"Rome","Lazio","00128",{"type":65,"coordinates":913},[914,915],12.51133,41.89193,{"lat":915,"lon":914},{"facility":57,"status":58,"city":909,"state":910,"zip":918,"country":901,"countryCode":902,"cosmosGeoPoint":919,"geoPoint":921,"contacts":10},"00168",{"type":65,"coordinates":920},[914,915],{"lat":915,"lon":914},{"facility":57,"status":58,"city":923,"state":924,"zip":925,"country":901,"countryCode":902,"cosmosGeoPoint":926,"geoPoint":930,"contacts":10},"Brescia","Lombardy","25123",{"type":65,"coordinates":927},[928,929],10.21472,45.53558,{"lat":929,"lon":928},{"facility":57,"status":58,"city":932,"state":924,"zip":933,"country":901,"countryCode":902,"cosmosGeoPoint":934,"geoPoint":938,"contacts":10},"Milan","20132",{"type":65,"coordinates":935},[936,937],9.18951,45.46427,{"lat":937,"lon":936},{"facility":57,"status":58,"city":932,"state":924,"zip":940,"country":901,"countryCode":902,"cosmosGeoPoint":941,"geoPoint":943,"contacts":10},"20133",{"type":65,"coordinates":942},[936,937],{"lat":937,"lon":936},{"facility":57,"status":58,"city":945,"state":924,"zip":946,"country":901,"countryCode":902,"cosmosGeoPoint":947,"geoPoint":951,"contacts":10},"Rozzano","20089",{"type":65,"coordinates":948},[949,950],9.1559,45.38193,{"lat":950,"lon":949},{"facility":57,"status":58,"city":953,"state":954,"zip":955,"country":901,"countryCode":902,"cosmosGeoPoint":956,"geoPoint":960,"contacts":10},"Turin","Piedmont","10126",{"type":65,"coordinates":957},[958,959],7.68682,45.07049,{"lat":959,"lon":958},{"facility":57,"status":58,"city":962,"state":963,"zip":964,"country":901,"countryCode":902,"cosmosGeoPoint":965,"geoPoint":969,"contacts":10},"Monserrato","Sardinia","09042",{"type":65,"coordinates":966},[967,968],9.1444,39.25642,{"lat":968,"lon":967},{"facility":57,"status":58,"city":971,"state":972,"zip":973,"country":901,"countryCode":902,"cosmosGeoPoint":974,"geoPoint":978,"contacts":10},"Pisa","Tuscany","56124",{"type":65,"coordinates":975},[976,977],10.4036,43.70853,{"lat":977,"lon":976},{"facility":57,"status":58,"city":980,"state":981,"zip":982,"country":983,"countryCode":984,"cosmosGeoPoint":985,"geoPoint":989,"contacts":10},"Nagoya","Aichi-ken","466-8550","Japan","JP",{"type":65,"coordinates":986},[987,988],136.90641,35.18147,{"lat":988,"lon":987},{"facility":57,"status":58,"city":991,"state":992,"zip":993,"country":983,"countryCode":984,"cosmosGeoPoint":10,"geoPoint":10,"contacts":10},"Kashiwa-shi","Chiba","277-8577",{"facility":57,"status":58,"city":995,"state":996,"zip":997,"country":983,"countryCode":984,"cosmosGeoPoint":998,"geoPoint":1002,"contacts":10},"Kurume","Fukuoka","830-0011",{"type":65,"coordinates":999},[1000,1001],130.51667,33.31667,{"lat":1001,"lon":1000},{"facility":57,"status":58,"city":1004,"state":1005,"zip":1006,"country":983,"countryCode":984,"cosmosGeoPoint":1007,"geoPoint":1011,"contacts":10},"Kanazawa","Ishikawa-ken","920-8641",{"type":65,"coordinates":1008},[1009,1010],136.61667,36.6,{"lat":1010,"lon":1009},{"facility":57,"status":58,"city":1013,"state":1014,"zip":1015,"country":983,"countryCode":984,"cosmosGeoPoint":1016,"geoPoint":1020,"contacts":10},"Yokohama","Kanagawa","241-8515",{"type":65,"coordinates":1017},[1018,1019],139.65,35.43333,{"lat":1019,"lon":1018},{"facility":57,"status":58,"city":1022,"state":1022,"zip":1023,"country":983,"countryCode":984,"cosmosGeoPoint":1024,"geoPoint":1028,"contacts":10},"Kyoto","606-8507",{"type":65,"coordinates":1025},[1026,1027],135.75385,35.02107,{"lat":1027,"lon":1026},{"facility":57,"status":58,"city":1030,"state":1031,"zip":1032,"country":983,"countryCode":984,"cosmosGeoPoint":1033,"geoPoint":1037,"contacts":10},"Sendai","Miyagi","980-8574",{"type":65,"coordinates":1034},[1035,1036],140.86667,38.26667,{"lat":1036,"lon":1035},{"facility":57,"status":58,"city":1039,"state":1040,"zip":1041,"country":983,"countryCode":984,"cosmosGeoPoint":1042,"geoPoint":1046,"contacts":10},"Ōsaka-sayama","Osaka","589-8511",{"type":65,"coordinates":1043},[1044,1045],135.55069,34.49524,{"lat":1045,"lon":1044},{"facility":57,"status":58,"city":1048,"state":1049,"zip":1050,"country":1051,"countryCode":1052,"cosmosGeoPoint":1053,"geoPoint":1057,"contacts":10},"Bergen","Hordaland","5021","Norway","NO",{"type":65,"coordinates":1054},[1055,1056],5.32415,60.39299,{"lat":1056,"lon":1055},{"facility":57,"status":58,"city":1059,"state":1060,"zip":1061,"country":1051,"countryCode":1052,"cosmosGeoPoint":1062,"geoPoint":1066,"contacts":10},"Oslo","Ostlandet","379",{"type":65,"coordinates":1063},[1064,1065],10.74609,59.91273,{"lat":1065,"lon":1064},{"facility":57,"status":58,"city":1068,"state":1069,"zip":1070,"country":1071,"countryCode":1072,"cosmosGeoPoint":1073,"geoPoint":1077,"contacts":10},"Vila Real","North","5000-508","Portugal","PT",{"type":65,"coordinates":1074},[1075,1076],-7.7432,41.3001,{"lat":1076,"lon":1075},{"facility":57,"status":58,"city":1079,"state":10,"zip":1080,"country":1071,"countryCode":1072,"cosmosGeoPoint":1081,"geoPoint":1085,"contacts":10},"Faro","8000-386",{"type":65,"coordinates":1082},[1083,1084],-7.92716,37.01869,{"lat":1084,"lon":1083},{"facility":57,"status":58,"city":1087,"state":10,"zip":1088,"country":1071,"countryCode":1072,"cosmosGeoPoint":1089,"geoPoint":1093,"contacts":10},"Lisbon","1400 - 038",{"type":65,"coordinates":1090},[1091,1092],-9.1498,38.72509,{"lat":1092,"lon":1091},{"facility":57,"status":58,"city":1087,"state":10,"zip":1095,"country":1071,"countryCode":1072,"cosmosGeoPoint":1096,"geoPoint":1098,"contacts":10},"1649-028",{"type":65,"coordinates":1097},[1091,1092],{"lat":1092,"lon":1091},{"facility":57,"status":58,"city":1100,"state":1101,"zip":1102,"country":1103,"countryCode":1104,"cosmosGeoPoint":1105,"geoPoint":1109,"contacts":10},"San Juan","Rio Piedras","00935","Puerto Rico","PR",{"type":65,"coordinates":1106},[1107,1108],-66.10572,18.46633,{"lat":1108,"lon":1107},{"facility":57,"status":58,"city":1111,"state":10,"zip":1112,"country":1113,"countryCode":1114,"cosmosGeoPoint":1115,"geoPoint":1119,"contacts":10},"Bucharest","22328","Romania","RO",{"type":65,"coordinates":1116},[1117,1118],26.10626,44.43225,{"lat":1118,"lon":1117},{"facility":57,"status":58,"city":1121,"state":10,"zip":1122,"country":1113,"countryCode":1114,"cosmosGeoPoint":1123,"geoPoint":1127,"contacts":10},"Cluj-Napoca","400162",{"type":65,"coordinates":1124},[1125,1126],23.6,46.76667,{"lat":1126,"lon":1125},{"facility":57,"status":58,"city":1129,"state":10,"zip":1130,"country":1113,"countryCode":1114,"cosmosGeoPoint":1131,"geoPoint":1135,"contacts":10},"Craiova","200347",{"type":65,"coordinates":1132},[1133,1134],23.8,44.31667,{"lat":1134,"lon":1133},{"facility":57,"status":58,"city":1137,"state":10,"zip":1138,"country":1113,"countryCode":1114,"cosmosGeoPoint":1139,"geoPoint":1143,"contacts":10},"Iași","700483",{"type":65,"coordinates":1140},[1141,1142],27.6,47.16667,{"lat":1142,"lon":1141},{"facility":57,"status":58,"city":1145,"state":1146,"zip":1147,"country":1148,"countryCode":1149,"cosmosGeoPoint":1150,"geoPoint":1154,"contacts":10},"Riyadh","Ar Riyadh","12231","Saudi Arabia","SA",{"type":65,"coordinates":1151},[1152,1153],46.72185,24.68773,{"lat":1153,"lon":1152},{"facility":57,"status":58,"city":1156,"state":1157,"zip":1158,"country":1148,"countryCode":1149,"cosmosGeoPoint":1159,"geoPoint":1163,"contacts":10},"Jeddah","Mecca Region","22384",{"type":65,"coordinates":1160},[1161,1162],39.18624,21.49012,{"lat":1162,"lon":1161},{"facility":57,"status":58,"city":1165,"state":10,"zip":1166,"country":1165,"countryCode":1167,"cosmosGeoPoint":1168,"geoPoint":1172,"contacts":10},"Singapore","169610","SG",{"type":65,"coordinates":1169},[1170,1171],103.85007,1.28967,{"lat":1171,"lon":1170},{"facility":57,"status":58,"city":1165,"state":10,"zip":1174,"country":1165,"countryCode":1167,"cosmosGeoPoint":1175,"geoPoint":1177,"contacts":10},"329563",{"type":65,"coordinates":1176},[1170,1171],{"lat":1171,"lon":1170},{"facility":57,"status":58,"city":1179,"state":1180,"zip":1181,"country":1182,"countryCode":1183,"cosmosGeoPoint":1184,"geoPoint":1188,"contacts":10},"Santiago de Compostela","A Coruna","15706","Spain","ES",{"type":65,"coordinates":1185},[1186,1187],-8.54569,42.88052,{"lat":1187,"lon":1186},{"facility":57,"status":58,"city":1190,"state":1191,"zip":1192,"country":1182,"countryCode":1183,"cosmosGeoPoint":1193,"geoPoint":1197,"contacts":10},"Zaragoza","Aragon","50009",{"type":65,"coordinates":1194},[1195,1196],-0.87734,41.65606,{"lat":1196,"lon":1195},{"facility":57,"status":58,"city":1199,"state":1200,"zip":1201,"country":1182,"countryCode":1183,"cosmosGeoPoint":1202,"geoPoint":1206,"contacts":10},"Santander","Cantabria","39008",{"type":65,"coordinates":1203},[1204,1205],-3.80493,43.46589,{"lat":1205,"lon":1204},{"facility":57,"status":58,"city":1208,"state":1209,"zip":1210,"country":1182,"countryCode":1183,"cosmosGeoPoint":1211,"geoPoint":1215,"contacts":10},"Burgos","Castille and León","9006",{"type":65,"coordinates":1212},[1213,1214],-3.70184,42.34106,{"lat":1214,"lon":1213},{"facility":57,"status":58,"city":1217,"state":1218,"zip":1219,"country":1182,"countryCode":1183,"cosmosGeoPoint":10,"geoPoint":10,"contacts":10},"Poniente Sur","Cordoba","14004",{"facility":57,"status":58,"city":1221,"state":1222,"zip":1223,"country":1182,"countryCode":1183,"cosmosGeoPoint":1224,"geoPoint":1228,"contacts":10},"Ourense","Galicia","32005",{"type":65,"coordinates":1225},[1226,1227],-7.86407,42.33669,{"lat":1227,"lon":1226},{"facility":57,"status":58,"city":1230,"state":1231,"zip":1232,"country":1182,"countryCode":1183,"cosmosGeoPoint":1233,"geoPoint":1237,"contacts":10},"Majadahonda","Madrid","28222",{"type":65,"coordinates":1234},[1235,1236],-3.87182,40.47353,{"lat":1236,"lon":1235},{"facility":57,"status":58,"city":1239,"state":1240,"zip":1241,"country":1182,"countryCode":1183,"cosmosGeoPoint":1242,"geoPoint":1246,"contacts":10},"El Palmar","Murcia","30120",{"type":65,"coordinates":1243},[1244,1245],-1.16095,37.93939,{"lat":1245,"lon":1244},{"facility":57,"status":58,"city":1248,"state":10,"zip":1249,"country":1182,"countryCode":1183,"cosmosGeoPoint":1250,"geoPoint":1254,"contacts":10},"Barcelona","8035",{"type":65,"coordinates":1251},[1252,1253],2.15899,41.38879,{"lat":1253,"lon":1252},{"facility":57,"status":58,"city":1231,"state":10,"zip":1256,"country":1182,"countryCode":1183,"cosmosGeoPoint":1257,"geoPoint":1261,"contacts":10},"28007",{"type":65,"coordinates":1258},[1259,1260],-3.70256,40.4165,{"lat":1260,"lon":1259},{"facility":57,"status":58,"city":1231,"state":10,"zip":1263,"country":1182,"countryCode":1183,"cosmosGeoPoint":1264,"geoPoint":1266,"contacts":10},"28034",{"type":65,"coordinates":1265},[1259,1260],{"lat":1260,"lon":1259},{"facility":57,"status":58,"city":1231,"state":10,"zip":1268,"country":1182,"countryCode":1183,"cosmosGeoPoint":1269,"geoPoint":1271,"contacts":10},"28040",{"type":65,"coordinates":1270},[1259,1260],{"lat":1260,"lon":1259},{"facility":57,"status":58,"city":1231,"state":10,"zip":1273,"country":1182,"countryCode":1183,"cosmosGeoPoint":1274,"geoPoint":1276,"contacts":10},"28041",{"type":65,"coordinates":1275},[1259,1260],{"lat":1260,"lon":1259},{"facility":57,"status":58,"city":1278,"state":10,"zip":1279,"country":1182,"countryCode":1183,"cosmosGeoPoint":1280,"geoPoint":1284,"contacts":10},"Oviedo","33011",{"type":65,"coordinates":1281},[1282,1283],-5.84476,43.36029,{"lat":1283,"lon":1282},{"facility":57,"status":58,"city":1286,"state":10,"zip":1287,"country":1182,"countryCode":1183,"cosmosGeoPoint":1288,"geoPoint":1292,"contacts":10},"Pamplona","31008",{"type":65,"coordinates":1289},[1290,1291],-1.64323,42.81687,{"lat":1291,"lon":1290},{"facility":57,"status":58,"city":1294,"state":10,"zip":1295,"country":1182,"countryCode":1183,"cosmosGeoPoint":1296,"geoPoint":1300,"contacts":10},"Santa Cruz de Tenerife","38010",{"type":65,"coordinates":1297},[1298,1299],-16.25462,28.46824,{"lat":1299,"lon":1298},{"facility":57,"status":58,"city":1302,"state":10,"zip":1303,"country":1182,"countryCode":1183,"cosmosGeoPoint":1304,"geoPoint":1308,"contacts":10},"Seville","41009",{"type":65,"coordinates":1305},[1306,1307],-5.97317,37.38283,{"lat":1307,"lon":1306},{"facility":57,"status":58,"city":1310,"state":10,"zip":1311,"country":1182,"countryCode":1183,"cosmosGeoPoint":1312,"geoPoint":1316,"contacts":10},"Valencia","46010",{"type":65,"coordinates":1313},[1314,1315],-0.37966,39.47391,{"lat":1315,"lon":1314},{"facility":57,"status":58,"city":1318,"state":1319,"zip":1320,"country":1321,"countryCode":1322,"cosmosGeoPoint":1323,"geoPoint":1327,"contacts":10},"Lausanne","Canton of Vaud","1005","Switzerland","CH",{"type":65,"coordinates":1324},[1325,1326],6.63282,46.516,{"lat":1326,"lon":1325},{"facility":57,"status":58,"city":1329,"state":10,"zip":1330,"country":1321,"countryCode":1322,"cosmosGeoPoint":1331,"geoPoint":1335,"contacts":10},"Zurich","8032",{"type":65,"coordinates":1332},[1333,1334],8.55,47.36667,{"lat":1334,"lon":1333},{"facility":57,"status":58,"city":1337,"state":1338,"zip":1339,"country":1340,"countryCode":1341,"cosmosGeoPoint":1342,"geoPoint":1346,"contacts":10},"Taichung","Taichung City","40705","Taiwan","TW",{"type":65,"coordinates":1343},[1344,1345],120.6839,24.1469,{"lat":1345,"lon":1344},{"facility":57,"status":58,"city":1348,"state":10,"zip":1349,"country":1340,"countryCode":1341,"cosmosGeoPoint":1350,"geoPoint":1354,"contacts":10},"Kaohsiung City","82445",{"type":65,"coordinates":1351},[1352,1353],120.31333,22.61626,{"lat":1353,"lon":1352},{"facility":57,"status":58,"city":1356,"state":10,"zip":1357,"country":1340,"countryCode":1341,"cosmosGeoPoint":1358,"geoPoint":1362,"contacts":10},"Taipei","100225",{"type":65,"coordinates":1359},[1360,1361],121.52639,25.05306,{"lat":1361,"lon":1360},{"facility":57,"status":58,"city":1356,"state":10,"zip":1364,"country":1340,"countryCode":1341,"cosmosGeoPoint":1365,"geoPoint":1367,"contacts":10},"11217",{"type":65,"coordinates":1366},[1360,1361],{"lat":1361,"lon":1360},{"facility":57,"status":58,"city":1369,"state":10,"zip":1370,"country":1340,"countryCode":1341,"cosmosGeoPoint":1371,"geoPoint":1375,"contacts":10},"Taoyuan City","33305",{"type":65,"coordinates":1372},[1373,1374],121.29696,24.99368,{"lat":1374,"lon":1373},{"facility":57,"status":58,"city":1377,"state":1378,"zip":1379,"country":1380,"countryCode":1381,"cosmosGeoPoint":1382,"geoPoint":1386,"contacts":10},"Mohammed Bin Zayed City","Abu Dhabi Emirate","92510","United Arab Emirates","AE",{"type":65,"coordinates":1383},[1384,1385],54.55368,24.34794,{"lat":1385,"lon":1384},{"facility":57,"status":58,"city":1388,"state":1389,"zip":1390,"country":1380,"countryCode":1381,"cosmosGeoPoint":1391,"geoPoint":1395,"contacts":10},"Deira","Dubai","7272",{"type":65,"coordinates":1392},[1393,1394],55.30207,25.27143,{"lat":1394,"lon":1393},{"type":1397,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[1399],{"name":1400,"class":6},"ICON plc","100535509","observational-study-protocol-liver-r-100535509",false,"NCT06252753","Observational Study Protocol: LIVER-R","An Observational Multi-Center Study to Evaluate Real-World Treatment Outcomes With or Without Durvalumab-Based Regimens in Hepatobiliary Cancers","LIVER-R","Inclusion Criteria General Inclusion Criteria\n\nAll patients must meet all of the following general criteria 1-4 along with all respective cohort specific criteria noted below:\n\n1. Age ≥18 years and a lawful adult in the country at the index date\n2. Confirmed presence of malignancy of primary hepatobiliary cancer by any method (e.g., radiological, histological, etc.)\n3. Decision to treat was made independently and prior to obtaining informed consent\n4. Informed consent was obtained as per country level regulations (includes waiver of consent for retrospective data collection if approved)\n\naBTC Specific Inclusion Criteria\n\nA patient will be eligible to be included in the aBTC cohort if they meet all general inclusion criteria 1-4 in addition to the following criteria:\n\n1. Patient has unresectable aBTC\n2. Has received or is intending to receive a durvalumab-based regimen (may have been treated in an EAP)\n\nuHCC Specific Inclusion Criteria\n\nA patient will be eligible to be included in the uHCC cohort if they meet all general inclusion criteria 1-4 in addition to the following criteria:\n\n1. Patient has unresectable uHCC\n2. Not eligible for LRT, as well as for those who progressed following LRT\n3. Has received or is intending to receive a durvalumab-based regimen (may have been treated in an EAP)\n\neeHCC Specific Inclusion Criteria\n\nA patient will be eligible to be included in the eeHCC cohort if they meet all general inclusion criteria 1-4 in addition to the following criteria:\n\n1. HCC confirmed by radiological or histological diagnosis\n2. Child-Pugh A-B7\n3. Disease not amenable to curative treatment but amenable to LRT at index\n4. Patients with liver-confined HCC who initiated first non-curative intent LRT on or after 01 January 2024\n5. Patients eligible for LRT with palliative intent such as TACE\u002F TARE\u002Ftransarterial infusion chemotherapy (TAIC)\u002F hepatic arterial infusion chemotherapy (HAIC)\u002Ftransarterial embolization (TAE) given by itself or in combination with other systemic therapy (can include durvalumab) within 60 days of the LRT\n\nEMERALD Specific Inclusion Criteria\n\nA patient will be eligible to be included in the EMERALD cohort if they meet all general inclusion criteria 1-4 in addition to the following criteria:\n\n1. HCC confirmed by radiological or histological diagnosis\n2. Child-Pugh score of A-B7\n3. Liver-confined disease not amenable to curative treatment but amenable to LRT at index\n4. Receipt of a durvalumab-based regimen in combination with LRT administered within 28 days of each other (index is the first of the two treatments administered)\n\nExclusion Criteria\n\nGeneral Exclusion Criteria\n\nA patient will be excluded from participating in this study if they meet any of the following general criteria 1-2 or any cohort specific exclusion criteria:\n\n1. Currently\u002Fwas participating or plans to participate in any clinical trial for investigational treatment for hepatobiliary cancers on or after the diagnosis date until the index date\n2. Second primary malignancy prior to HCC or BTC diagnosis\n\naBTC Specific Exclusion Criteria\n\nA patient will be excluded from participating in the aBTC cohort if they meet any of the general exclusion criteria 1-2 or any of the following criteria:\n\n1. Received a liver transplant during the baseline period\n2. Received more than 1 cycle of Gemcitabine + Cisplatin for biliary tract cancer on or after diagnosis of unresectable, locally advanced or metastatic disease through the index date. Patients who received any systemic therapy while having early stage, resectable disease are eligible\n\nuHCC Specific Exclusion Criteria\n\nA patient will be excluded from participating in the uHCC cohort if they meet any of the general exclusion criteria 1-2 or any of the following criteria:\n\n1. Received a liver transplant during the baseline period\n2. Received other systemic therapies for hepatobiliary cancer indication on or after diagnosis date through the index date\n\neeHCC Specific Exclusion Criteria\n\nA patient will be excluded from participating in the eeHCC cohort if they meet any of the general exclusion criteria 1-2 or any of the following criteria:\n\n1. Eligible for curative therapy at the time of receiving LRT (ablation)\n2. Extrahepatic spread\n3. Portal vein tumor thrombosis (PVTT) of VP3\u002F4\n4. Receipt of systemic therapy prior to index LRT in the baseline period\n5. Liver transplant any time prior to index\n\nEMERALD Specific Exclusion Criteria\n\nA patient will be excluded from participating in the EMERALD cohort if they meet any of the general exclusion criteria 1-2 or any of the following criteria:\n\n1. Eligible for curative therapy at the time of receiving LRT (ablation)\n2. Extrahepatic spread\n3. Portal vein tumor thrombosis (PVTT) of VP3\u002F4\n4. Receipt of systemic therapy prior to index LRT in the baseline period\n5. Liver transplant any time prior to index","ALL","18 Years","130 Years",{"count":1413,"type":1414},4000,"ESTIMATED","OBSERVATIONAL","Given the number of anticipated durvalumab-based treatment launches in the hepatobiliary cancer space over the next 3 years, there is a need to capture contemporary real-world data across these indications. LIVER-R is a multi-country, multi-center, observational study of patients with a confirmed diagnosis of hepatobiliary cancer treated with or without a durvalumab-based regimen as part of routine clinical practice or early access program (EAP). The study design will include primary and secondary data collection. The primary objective of this study is to evaluate the effectiveness of regimens (durvalumab-based or otherwise) in real-world settings as measured by real-world overall survival. Other endpoints include demographics, clinical characteristics, clinically significant events of interest, treatment patterns, concomitant medications, treatment provider characteristics, and other real-world clinical endpoints (such as duration of treatment, progression-free survival, time to treatment progression, time to next treatment, time to treatment discontinuation, recurrence-free survival, and time to treatment recurrence).",[1418],"Hepatobiliary Cancers",[1420,1421,1422,1423,1424,1425,1426],"Hepatobiliary cancer","Unresectable hepatocellular carcinoma (uHCC)","embolization eligible uHCC (eeHCC)","Advanced biliary tract cancer (aBTC)","Durvalumab","Observatory","Real-world","2026-08-12",{"date":1429,"type":1430},"2026-08-13","ACTUAL",{"date":1432,"type":1430},"2023-12-19",{"date":1434,"type":1414},"2030-12-30",{"name":5,"class":6},159]