[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659585":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":17,"armGroups":18,"interventions":13,"overallOfficials":13,"centralContacts":13,"locations":13,"responsibleParty":22,"collaborators":13,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":31,"acronym":13,"eligibilityCriteria":32,"healthyVolunteers":28,"sex":33,"minAge":34,"maxAge":13,"enrollmentInfo":35,"targetDuration":13,"studyType":38,"phases":13,"briefSummary":39,"conditions":40,"keywords":45,"overallStatus":54,"whyStopped":13,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":13},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Change in Best-Corrected Visual Acuity (BCVA)","Best-corrected visual acuity (BCVA) is measured using standard ophthalmic charts and converted to logarithm of the minimum angle of resolution (logMAR) units for quantitative analysis. Lower logMAR values indicate better visual acuity. The change is calculated as the postoperative value minus the preoperative baseline value.","Baseline and 1 month after silicone oil removal",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","Adult patients aged 18 years or older scheduled for planned silicone oil removal following previous vitreoretinal surgery, recruited from the Vitreoretinal Unit, Department of Ophthalmology, Assiut University Hospitals.",[19],{"label":20,"type":13,"description":21,"interventionNames":13},"Patients Undergoing Silicone Oil Removal","Adult patients aged 18 years or older scheduled for planned silicone oil removal following prior vitreoretinal surgery (one eye per patient). All participants undergo baseline clinical ophthalmic examination and macular optical coherence tomography (OCT) imaging prior to silicone oil removal. Postoperative visual outcome, assessed by best-corrected visual acuity (BCVA), is evaluated at a follow-up visit occurring at least 1 month after silicone oil removal.",{"type":23,"investigatorFullName":24,"investigatorTitle":25,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Mohamed Sayed Mahmoud Abdelhafiz","Resident","100659585","oct-macula-biomarkers-before-silicone-oil-removal-and-visual-outcome-after-silicone-oil-removal-100659585",false,"NCT07865468","OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil Removal","Relationship Between OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil Removal","Inclusion Criteria:\n\n* Age 18 years or older.\n* Scheduled for silicone oil removal after previous vitreoretinal surgery.\n* Adequate macular optical coherence tomography (OCT) image quality before silicone oil removal.\n* Ability and willingness to attend postoperative follow-up.\n\nExclusion Criteria:\n\n* Active retinal pathology or any intraocular condition requiring additional vitreoretinal surgery at the time of silicone oil removal.\n* Significant media opacity preventing reliable best-corrected visual acuity (BCVA) or OCT assessment.\n* Pre-existing macular disease unrelated to the original retinal pathology that is expected to independently affect visual acuity.\n* Advanced glaucoma or optic neuropathy likely to be a major independent cause of visual loss.\n* Inability to complete postoperative follow-up.","ALL","18 Years",{"count":36,"type":37},30,"ESTIMATED","OBSERVATIONAL","Silicone oil is commonly used as a temporary intraocular tamponade to support the retina during vitreoretinal surgery for complex retinal detachment and other severe retinal conditions. Although removing silicone oil typically leads to visual improvement, the degree of visual recovery varies widely among patients. Optical coherence tomography (OCT) is a non-invasive imaging technique that provides detailed cross-sectional views of the macula, the central portion of the retina responsible for detailed vision.\n\nThe primary aim of this observational study is to evaluate the relationship between specific macular OCT biomarkers (such as central macular thickness, ellipsoid zone integrity, and macular edema) measured before silicone oil removal and visual outcomes after surgery. Identifying these structural features may help ophthalmologists better predict visual recovery and counsel patients prior to surgery.\n\nParticipants will undergo a standard comprehensive ophthalmic examination, best-corrected visual acuity (BCVA) testing, and a macular OCT scan prior to their scheduled silicone oil removal. Visual acuity will then be reassessed during a standard postoperative follow-up visit at least 1 month after surgery. Participation is observational and does not alter routine surgical or medical management.",[41,42,43,44],"Retinal Detachment","Macular Edema","Silicone Oil Tamponade","Epiretinal Membrane",[46,47,48,49,50,51,52,53],"Silicone oil removal","Optical coherence tomography","Macular biomarkers","Ellipsoid zone integrity","Central macular thickness","Best-corrected visual acuity","Vitreoretinal surgery","Cystoid macular edema","NOT_YET_RECRUITING","2026-10-03",{"date":57,"type":58},"2026-10-08","ACTUAL",{"date":60,"type":37},"2026-11",{"date":62,"type":37},"2027-12",{"name":5,"class":6}]