[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648597":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":27,"responsibleParty":43,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":73,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Benha University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Traumatic Brain Injury Patients Undergoing Osmotherapy Weaning",null,"Adult patients with traumatic brain injury receiving osmotherapy for intracranial hypertension who undergo protocol-defined osmotherapy weaning. Participants will undergo serial optic nerve sheath diameter (ONSD) measurements before and after osmotherapy reduction or discontinuation and will be followed prospectively for the development of rebound intracranial hypertension and related clinical outcomes.",[13],"Diagnostic Test: Optic Nerve Sheath Diameter Ultrasonography",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Optic Nerve Sheath Diameter Ultrasonography","Serial ultrasonographic measurement of optic nerve sheath diameter (ONSD) will be performed bilaterally using a standardized transorbital ultrasound technique immediately before osmotherapy reduction or discontinuation (baseline) and at 4, 6, 12, and 24 hours after weaning. Additional measurements may be obtained if clinical deterioration suggestive of rebound intracranial hypertension occurs. ONSD measurements are performed for observational purposes only and will not influence routine clinical management.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"Mostafa Mohamed Sakr, Critical care MSC","CONTACT","+201002338765","+201069610038","sasasakr6@gmail.com",[28],{"facility":29,"status":10,"city":30,"state":31,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Benha university hospital","Banhā","Qalyobia","Egypt","EG",{"type":35,"coordinates":36},"Point",[37,38],31.1842,30.45977,{"lat":38,"lon":37},[41],{"name":42,"role":23,"phone":24,"phoneExt":10,"email":26},"Mostafa M Abdelgwad, MSC",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mostafa Mohamed","Critical care assistant lecturer","100648597","onsd-trajectory-in-rebound-ich-100648597",false,"NCT07722702","ONSD Trajectory in Rebound ICH","Optic Nerve Sheath Diameter Trajectory During Osmotherapy Weaning as a Predictor of Rebound Intracranial Hypertension in Traumatic Brain Injury","ONSD\u002F INH","Inclusion Criteria:\n\n* Adults (≥18 years) with blunt traumatic brain injury admission GCS ≤12\n* (or GCS 13-15 with CT signs of elevated ICP including midline shift ≥5 mm, effaced cisterns, or significant cerebral edema)\n* clinical decision to initiate 20% mannitol osmotherapy\n\nExclusion Criteria:\n\n* Ocular conditions precluding ONSD measurement (glaucoma, prior ocular surgery,\n* globe or optic nerve trauma,\n* periorbital edema, orbital masses, optic nerve sheath cysts);\n* planned decompressive surgery or evacuation of mass lesion within 48 hours; limitation of life-sustaining therapy; pregnancy; contraindications to mannitol (baseline sodium \\>155 mEq\u002FL, osmolality \\>320 mOsm\u002Fkg, eGFR \\\u003C30 mL\u002Fmin); penetrating TBI; or concurrent spinal cord injury with shock.","ALL","18 Years","80 Years",{"count":59,"type":60},100,"ESTIMATED","6 Weeks","OBSERVATIONAL","The goal of this prospective observational study is to determine whether the trajectory of optic nerve sheath diameter (ONSD) after osmotherapy weaning can predict rebound intracranial hypertension in adult patients with traumatic brain injury requiring osmotherapy for elevated intracranial pressure. The main questions it aims to answer are:\n\nDoes the trajectory of ONSD during osmotherapy weaning predict the development of rebound intracranial hypertension? What is the diagnostic accuracy of serial ONSD measurements for the early detection of rebound intracranial hypertension? Researchers will compare patients who develop rebound intracranial hypertension with those who do not to determine whether changes in ONSD trajectory differ significantly between the two groups.\n\nParticipants will:\n\nUndergo serial bedside ocular ultrasound examinations for ONSD measurement at predefined time points after osmotherapy weaning.\n\nReceive standard clinical management for traumatic brain injury according to institutional protocols; no additional therapeutic intervention will be administered.\n\nUndergo routine neurological assessments, laboratory investigations, and neuroimaging as clinically indicated.\n\nBe followed for the occurrence of rebound intracranial hypertension and relevant clinical outcomes during their ICU stay",[65,66,67],"Traumatic Brain Injury","Rebound Intracranial Hypertension","Cerebral Edema",[69,70,71,72],"ONSD","Osmotherapy","Rebound ICH","Cerebral edema","NOT_YET_RECRUITING","2026-07-19",{"date":76,"type":77},"2026-07-23","ACTUAL",{"date":79,"type":60},"2026-09-01",{"date":81,"type":60},"2027-10-01",{"name":5,"class":6},1]