[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655611":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":33,"studyPopulation":34,"armGroups":35,"interventions":46,"overallOfficials":54,"centralContacts":58,"locations":68,"responsibleParty":111,"collaborators":113,"id":118,"slug":119,"hasResults":120,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":29,"eligibilityCriteria":124,"healthyVolunteers":125,"sex":126,"minAge":127,"maxAge":29,"enrollmentInfo":128,"targetDuration":29,"studyType":131,"phases":29,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":70,"whyStopped":29,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":153},{"fullName":5,"class":6},"AUVA General Trauma Hospital Salzburg","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Change in Boston Carpal Tunnel Questionnaire (BCTQ) Score","Mean difference in the change in the Boston Carpal Tunnel Questionnaire (BCTQ) score, combining the Symptom Severity Scale and Functional Status Scale, from the preoperative assessment (T0) to the 3-month postoperative assessment (T3).","Baseline to 3 months postoperatively",[14,18,21,25],{"measure":15,"description":16,"timeFrame":17},"Pain Intensity - Visual Analog Scale (VAS), 0-10","Change in pain intensity measured using the Visual Analog Scale (VAS), ranging from 0 to 10.","Preoperatively and at 2 weeks, 6 weeks, 3 months, and 12 months postoperatively",{"measure":19,"description":20,"timeFrame":17},"Subjective Hand Function - Single Assessment Numeric Evaluation (SANE), 0-100%","Subjective hand function measured using the Single Assessment Numeric Evaluation (SANE), ranging from 0 to 100%.",{"measure":22,"description":23,"timeFrame":24},"Time to Full Return to Work - Number of Days After Surgery","Number of days from surgery until full return to work.","Up to 3 months postoperatively",{"measure":26,"description":27,"timeFrame":28},"Postoperative Complications - Frequency of Wound Infection, Persistent Numbness, and Revision Surgery","Frequency of wound infections, persistent numbness, or required revision procedures.","Within 12 months after surgery",null,{"allocation":29,"interventionModel":29,"interventionModelDescription":29,"primaryPurpose":29,"observationalModel":31,"timePerspective":32,"maskingInfo":29},"COHORT","PROSPECTIVE","Carpal Tunnel Syndrome (CTS) is the most common compression neuropathy of the median nerve. Open Surgical Carpal Tunnel Release (OSCTR) has been established as the clinical gold standard. However, the procedure is associated with a palmar incision and may result in scar pain, including pillar pain, and delayed return to manual activities.\n\nUltrasound-Guided Carpal Tunnel Release (USGCTR) is a minimally invasive technique that permits division of the flexor retinaculum under continuous sonographic visualization through a minimal incision at the distal forearm or wrist crease. Potential advantages include avoidance of a painful scar in the load-bearing area of the hand and potentially faster recovery.\n\nThe study aims to compare functional recovery and symptom relief following OSCTR versus USGCTR. Secondary objectives include comparison of postoperative pain, subjective outcome, return to work, patient satisfaction, and complication rates.\n\nThis is a prospective, multicenter observational cohort study. Patients are not randomized. Assignment to the two cohorts is determined by the participating treatment center and its respective standard procedure. Patients choose the treatment center based on referral by their previously treating neurologist or on personal information. The study team does not influence this decision. Both procedures are established standard procedures routinely performed at the respective institutions.","Participants will be recruited during routine clinical consultations at the outpatient clinics of the participating centers. Patients fulfilling the inclusion criteria will be informed about the study by their treating physicians. Participation is voluntary and does not affect the quality of medical care.",[36,41],{"label":37,"type":29,"description":38,"interventionNames":39},"Open Surgical Carpal Tunnel Release (OSCTR)","Patients undergoing open surgical decompression at AUVA Unfallkrankenhaus Salzburg as the standard procedure of the participating center.",[40],"Procedure: Open Surgical Carpal Tunnel Release (OSCTR)",{"label":42,"type":29,"description":43,"interventionNames":44},"Ultrasound-Guided Carpal Tunnel Release (USGCTR)","Patients undergoing minimally invasive ultrasound-guided carpal tunnel release at the University Institute of Radiology, Paracelsus Medical Private University Salzburg, as the standard procedure of the participating center.",[45],"Procedure: Ultrasound-Guided Carpal Tunnel Release (USGCTR)",[47,51],{"type":48,"name":37,"description":49,"armGroupLabels":50,"otherNames":29},"PROCEDURE","Open surgical decompression of the carpal tunnel (OSCTR) is performed at UKH Salzburg as the established standard surgical treatment for carpal tunnel syndrome. The procedure involves open surgical release of the flexor retinaculum. Intraoperative findings and immediate complications are documented.",[37],{"type":48,"name":42,"description":52,"armGroupLabels":53,"otherNames":29},"Ultrasound-guided carpal tunnel release (USGCTR) is performed at the University Institute of Radiology of the Paracelsus Medical Private University. The minimally invasive procedure involves release of the flexor retinaculum under continuous sonographic visualization through a minimal incision at the distal forearm or wrist crease. Intraoperative findings and immediate complications are documented.",[42],[55],{"name":56,"affiliation":5,"role":57},"Thomas Hausner, Prim. Priv. Doz. Dr.","STUDY_CHAIR",[59,64],{"name":60,"role":61,"phone":62,"phoneExt":29,"email":63},"Alexander M.T. Paszicsnyek, Dr.","CONTACT","+43 5939344211","alexander.paszicsnyek@auva.at",{"name":65,"role":61,"phone":66,"phoneExt":29,"email":67},"Nikolaos Schörghofer, Dr.","+435725554901","n.schoerghofer@salk.at",[69,94],{"facility":5,"status":70,"city":71,"state":29,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"RECRUITING","Salzburg","5010","Austria","AT",{"type":76,"coordinates":77},"Point",[78,79],13.04399,47.79941,{"lat":79,"lon":78},[82,83,87,90,93],{"name":60,"role":61,"phone":62,"phoneExt":29,"email":63},{"name":84,"role":61,"phone":85,"phoneExt":29,"email":86},"Christoph Hirnsperger, Dr","+4359393 44253","christoph.hirnsperger@auva.at",{"name":88,"role":89,"phone":29,"phoneExt":29,"email":29},"Christoph Hirnsperger, Dr.","SUB_INVESTIGATOR",{"name":91,"role":92,"phone":29,"phoneExt":29,"email":29},"Alexander Paszicsnyek, Dr.","PRINCIPAL_INVESTIGATOR",{"name":56,"role":89,"phone":29,"phoneExt":29,"email":29},{"facility":95,"status":70,"city":71,"state":29,"zip":96,"country":73,"countryCode":74,"cosmosGeoPoint":97,"geoPoint":99,"contacts":100},"University Institute of Radiology, Paracelsus Medical Private University Salzburg","5020",{"type":76,"coordinates":98},[78,79],{"lat":79,"lon":78},[101,105,106,108,110],{"name":102,"role":61,"phone":103,"phoneExt":29,"email":104},"Christoph Knaptisch, Dr.","+43 5725554915","c.knapitsch@salk.at",{"name":65,"role":61,"phone":66,"phoneExt":29,"email":67},{"name":107,"role":89,"phone":29,"phoneExt":29,"email":29},"Klaus Hergan, Prof. Dr.",{"name":109,"role":92,"phone":29,"phoneExt":29,"email":29},"Christoph Knapitsch, Dr.",{"name":65,"role":89,"phone":29,"phoneExt":29,"email":29},{"type":112,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR",[114,116],{"name":115,"class":6},"Salzburger Landeskliniken",{"name":117,"class":6},"Paracelsus Medical University","100655611","open-vs-ultrasound-guided-carpal-tunnel-release-100655611",false,"NCT07814547","Open vs. Ultrasound-Guided Carpal Tunnel Release","Prospective Multicenter Trial Comparing Open Surgical Decompression Versus Minimally Invasive Ultrasound-Guided Carpal Tunnel Release","Inclusion Criteria:\n\n* Electrophysiologically verified Carpal Tunnel Syndrome by EMG\u002Fnerve conduction studies, with the examination not older than 6 months at the time of inclusion.\n* Previous documented and exhausted conservative treatment\n* Existing indication for surgery that has been discussed with the patient and the patient's explicit wish to undergo surgical treatment.\n* Ability to provide informed consent and written informed consent\n* Age ≥18 years.\n\nExclusion Criteria:\n\n* Previous surgery at the affected location or revision procedures.\n* Pre-existing nerve lesions of the upper extremity, including traumatic transections or proximal injuries.\n* Manifest polyneuropathy.\n* Foreseeable loss to follow-up, for example inability to contact the participant or insufficient compliance, before the critical 3-month follow-up.\n* Age under 18 years.",true,"ALL","18 Years",{"count":129,"type":130},200,"ESTIMATED","OBSERVATIONAL","Carpal Tunnel Syndrome (CTS) is the most prevalent entrapment neuropathy. Open Surgical Carpal Tunnel Release (OSCTR) remains the gold standard, while minimally invasive Ultrasound-Guided Carpal Tunnel Release (USGCTR) offers potential advantages including reduced postoperative morbidity and faster recovery. This prospective, multicenter observational cohort study compares the clinical outcomes, patient-reported outcomes, and socioeconomic impact of USGCTR versus OSCTR. A total of 200 patients, with 100 patients per cohort, will be included. Patient assignment is based on the participating center's standard of care. Follow-up assessments are performed preoperatively and at 2 weeks, 6 weeks, 3 months, and 12 months after surgery.",[134],"Carpal Tunnel Syndrome (CTS)",[136,137,138,139,140,141,142,143],"carpal tunnel syndrome","open surgical carpal tunnel release","ultrasound guided carpal tunnel release","osctr","usgctr","Boston carpal tunnel questionnaire","bctq","Return to Work","2026-09-06",{"date":146,"type":147},"2026-09-11","ACTUAL",{"date":149,"type":147},"2026-06-01",{"date":151,"type":130},"2028-07",{"name":5,"class":6},2]