[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627305":3},{"organization":4,"armGroups":7,"interventions":37,"overallOfficials":56,"centralContacts":43,"locations":60,"responsibleParty":75,"collaborators":43,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":43,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":43,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":100,"whyStopped":43,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14,19,24,29,33],{"label":9,"type":10,"description":11,"interventionNames":12},"High Protein Diet Only","ACTIVE_COMPARATOR","Enrollment in State of Slim (SOS) weight loss program with a high protein diet. This arm includes participants identified as responders to the high protein diet counseling in stage 1 at the week 8 assessment.",[13],"Behavioral: High Protein Diet Counceling",{"label":15,"type":10,"description":16,"interventionNames":17},"High Protein Diet + Supplement","Enrollment in State of Slim (SOS) weight loss program with a high protein diet. Participants identified as non-responders at the week 8 assessment will receive protein supplements to augment their intervention plan.",[13,18],"Behavioral: Protein Supplement",{"label":20,"type":10,"description":21,"interventionNames":22},"High Protein Diet + Supervised Exercise","Enrollment in State of Slim (SOS) weight loss program with a high protein diet. Participants identified as non-responders at the week 8 assessment will receive supervised resistance training sessions to augment their intervention plan.",[13,23],"Behavioral: Supervised Exercise",{"label":25,"type":10,"description":26,"interventionNames":27},"Standard Protein Diet Only","Enrollment in State of Slim (SOS) weight loss program with a standard protein diet. This arm includes participants identified as responders to the standard protein diet counseling in stage 1 at the week 8 assessment.",[28],"Behavioral: Standard Protein Diet Counceling",{"label":30,"type":10,"description":31,"interventionNames":32},"Standard Protein Diet + Supplement","Enrollment in State of Slim (SOS) weight loss program with a standard protein diet. Participants identified as non-responders at the week 8 assessment will receive protein supplements to augment their intervention plan.",[28,18],{"label":34,"type":10,"description":35,"interventionNames":36},"Standard Protein Diet + Supervised Exercise","Enrollment in State of Slim (SOS) weight loss program with a standard protein diet. Participants identified as non-responders at the week 8 assessment will receive supervised resistance training sessions to augment their intervention plan.",[28,23],[38,44,48,52],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"BEHAVIORAL","High Protein Diet Counceling","16 week group-based weight loss program with counseling to consume a high protein diet. Approximate macronutrient distributions (carbohydrate:protein:fat) will be 32%:40%:28%.",[20,15,9],null,{"type":39,"name":45,"description":46,"armGroupLabels":47,"otherNames":43},"Standard Protein Diet Counceling","16 week group-based weight loss program with counseling to consume a standard protein diet. Approximate macronutrient distributions (carbohydrate:protein:fat) will be 53%:20%:27%.",[34,30,25],{"type":39,"name":49,"description":50,"armGroupLabels":51,"otherNames":43},"Protein Supplement","Non-responders from either initial randomized group assigned to this intervention receive twice daily protein supplements.",[15,30],{"type":39,"name":53,"description":54,"armGroupLabels":55,"otherNames":43},"Supervised Exercise","Non-responders from either initial randomized group assigned to this intervention receive twice weekly small-group supervised resistance exercise training sessions.",[20,34],[57],{"name":58,"affiliation":5,"role":59},"Drew Sayer, MD","PRINCIPAL_INVESTIGATOR",[61],{"facility":5,"status":43,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Birmingham","Alabama","35233","United States","US",{"type":68,"coordinates":69},"Point",[70,71],-86.80249,33.52066,{"lat":71,"lon":70},[74],{"name":58,"role":59,"phone":43,"phoneExt":43,"email":43},{"type":59,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Drew Sayer","Assistant Professor","100627305","optimizing-adaptive-intensive-behavioral-therapy-for-obesity-during-the-transition-to-older-adulthood-100627305",false,"NCT07446907","Optimizing Adaptive Intensive Behavioral Therapy for Obesity During the Transition to Older Adulthood","Optimizing Adaptive Intensive Behavioral Therapy for Obesity During the Transition to Older Adulthood: A Sequential Multiple Assignment Randomized Trial","Inclusion Criteria:\n\n* Male or female sex\n* all racial and ethnic groups\n* BMI: 30-50 kg\u002Fm2\n* age 50-75 years\n* postmenopausal status for ≥1 y if female sex\n\nExclusion Criteria:\n\n* \\\u003C3 months stable use of other medications affecting body weight or appetite\n* \\>450 pounds (due to weight limitations of the DXA)\n* indication or previous diagnosis of sarcopenia\n* existing kidney disease\n* current binge eating disorder, anorexia, or bulimia\n* untreated hyper- or hypothyroidism, cancer (except basal cell), gastrointestinal disorders affecting food intake or nutrient absorption; any other medical condition, as determined by the study physician, precluding a HP diet and\u002For daily exercise","ALL","50 Years","75 Years",{"count":89,"type":90},250,"ESTIMATED","INTERVENTIONAL",[93],"NA","To test adaptive intensive behavioral therapy strategies comprising dietary patterns with varying amounts of protein and including supplemental protein or resistance exercise training for promoting weight loss and attenuating lean mass loss in adults aged 50-75 with obesity.",[96,97],"Obesity & Overweight","Sarcopenia",[99,97],"Obesity","NOT_YET_RECRUITING","2026-07-31",{"date":103,"type":104},"2026-08-03","ACTUAL",{"date":106,"type":90},"2026-09",{"date":108,"type":90},"2031-06-30",{"name":5,"class":6},1]