[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650179":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":29,"locations":39,"responsibleParty":54,"collaborators":28,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":28,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":28,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":83,"whyStopped":28,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"First Affiliated Hospital of Fujian Medical University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"30 Hz Difference Frequency tTIS","EXPERIMENTAL","Transcranial Temporal Interference Stimulation (tTIS) uses a difference frequency (Δf) of 30 Hz.",[13],"Device: Transcranial Temporal Interference Stimulation (tTIS)",{"label":15,"type":10,"description":16,"interventionNames":17},"40 Hz Difference Frequency tTIS","Transcranial Temporal Interference Stimulation (tTIS) uses a difference frequency (Δf) of 40 Hz.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"70 Hz Difference Frequency tTIS","Transcranial Temporal Interference Stimulation (tTIS) uses a difference frequency (Δf) of 70 Hz.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DEVICE","Transcranial Temporal Interference Stimulation (tTIS)","Participants assigned to this intervention arm receive transcranial temporal interference stimulation (tTIS) with a difference frequency (Δf) of 30Hz\u002F40Hz\u002F70 Hz.\n\nBefore treatment, individualized electric field modeling is performed based on each participant's 3D-T1 MRI data to optimize electrode placement and stimulation parameters. The stimulation target is the bilateral cerebellar dentate nuclei. A personalized finite element head model is generated, and electrode positions are determined through simulation-based optimization to achieve focused interference electric fields at the target region.\n\nDuring each treatment session, tTIS is delivered using two carrier frequencies of 2000 Hz and 2030Hz\u002F2040Hz\u002F2070 Hz, with a current intensity of 2.0 mA (zero-to-peak). Each session lasts 20 minutes. Treatment is administered twice daily, 5 days per week, for a total of 10 sessions.",[9,15,19],null,[30,35],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":34},"Xin-Yuan Chen","CONTACT","+86 15005065282","fychenxinyuan@fjmu.edu.cn",{"name":36,"role":32,"phone":37,"phoneExt":28,"email":38},"Kai-Xiong Chen","+86 15280096886","1002297884@qq.com",[40],{"facility":41,"status":28,"city":42,"state":43,"zip":28,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University","Fuzhou","Fujian","China","CN",{"type":47,"coordinates":48},"Point",[49,50],119.30611,26.06139,{"lat":50,"lon":49},[53],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":34},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","Xinyuan Chen","Principal Investigator","100650179","optimizing-parameters-of-transcranial-temporal-interference-stimulation-for-spinocerebellar-ataxia-type-3-100650179",false,"NCT07743866","Optimizing Parameters of Transcranial Temporal Interference Stimulation for Spinocerebellar Ataxia Type 3","Efficacy and Safety of Transcranial Temporal Interference Stimulation of the Cerebellar Dentate Nucleus Using Individualized Head Modeling in Patients With Spinocerebellar Ataxia Type 3","Inclusion Criteria:\n\n1. A physician-diagnosed SCA3 according to diagnostic criteria, with definite clinical symptoms and confirmed genetic testing;\n2. Age 18-75 years;\n3. Baseline total score of SARA: 8-30 points (inclusive); SARA gait function subscore: 2-6 points (inclusive);\n4. Willing to participate and provide informed consent;\n5. Have a reliable caregiver available;\n6. No severe cognitive impairment that would preclude reliable reporting of adverse events or efficacy during treatment.\n\nExclusion Criteria:\n\n1. History of seizures or convulsions, or a seizure within 6 months prior to enrolment;\n2. History of severe traumatic brain injury or intracranial neurosurgery;\n3. Presence of cardiac pacemakers, cochlear implants, intracranial implanted electronic devices, or other MRI-contraindicated ferromagnetic implants;\n4. Severe cognitive impairment (Mini-Mental State Examination \\[MMSE\\] score ≤ 9) or severe visual, auditory, or speech dysfunction preventing cooperation with scale assessments and study procedures;\n5. Pregnant or lactating women, or women of childbearing age not using reliable contraception;\n6. Previous neuromodulation treatment (e.g., rTMS or tDCS) within the past year;\n7. Skin breakdown or inflammation at the electrode placement site, or known allergy to conductive gel or electrode patch adhesives;\n8. Currently participating in other interventional clinical trials, or planning to participate in other trials that might affect the outcome assessment of this study during the study period.","ALL","18 Years","75 Years",{"count":69,"type":70},24,"ESTIMATED","INTERVENTIONAL",[73],"NA","The purpose of this research study is to identify the optimal biological dose for tTIS that targets DN in SCA3 while achieving the best possible balance between therapeutic efficacy and safety.",[76],"Spinocerebellar Ataxia Type 3",[78,79,80,81,82],"Transcranial Temporal Interference stimulation","Spinocerebellar ataxia type 3","Cerebellar dentate nucleus","Stimulation difference frequency","Individualized head modeling","NOT_YET_RECRUITING","2026-08-03",{"date":86,"type":87},"2026-08-05","ACTUAL",{"date":89,"type":70},"2026-08-07",{"date":91,"type":70},"2027-02-28",{"name":5,"class":6},1]