[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620402":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":17,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":57,"collaborators":17,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":17,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":17,"studyType":74,"phases":17,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":83,"whyStopped":17,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University Hospital Center (CHU) of Constantine, Algeria","OTHER_GOV",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Differences in salivary inflammatory biomarker profiles between stroke patients and healthy controls.","Assessment of salivary inflammatory and neuroendocrine biomarkers, including salivary cortisol and selected inflammatory cytokines (e.g., IL-6 and\u002For hs-CRP), to identify biomarker patterns associated with stroke.","Single time-point assessment at enrollment",[14],{"measure":15,"description":16,"timeFrame":12},"Exploratory association between oral microbiota profiles and stroke status","Exploratory analysis of the association between oral microbiota profiles and stroke status using saliva or oral swab samples. The analysis aims to identify bacterial profiles potentially associated with stroke and oral-systemic interactions.",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"CASE_CONTROL","CROSS_SECTIONAL","Stroke is a major cause of morbidity and mortality worldwide. Growing scientific evidence suggests that oral health and salivary biomarkers may reflect systemic inflammatory and vascular conditions.\n\nThis observational study is designed to evaluate associations between oral clinical findings, salivary biomarkers, and stroke. Participants with a confirmed diagnosis of stroke will be enrolled. Data collection will include demographic information, medical history, oral examination findings, and salivary samples.\n\nAnalyses will focus on identifying correlations between oral and salivary parameters and clinical characteristics of stroke. This study does not involve any therapeutic intervention or experimental treatment. The findings may contribute to a better understanding of the oral-systemic relationship in cerebrovascular diseases and support future preventive strategies.","Patients will be recruited from multiple regions within Algeria, reflecting a diverse national population.",[24,27],{"label":25,"type":17,"description":26,"interventionNames":17},"Stroke group","Patients diagnosed with stroke.",{"label":28,"type":17,"description":29,"interventionNames":17},"Healthy control group","Healthy participants without a history of stroke.",[31],{"name":32,"affiliation":33,"role":34},"Abdeldjalil Zitouni, DDS","Independent Researcher, Constantine, Algeria","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":17,"email":39},"CONTACT","+213550400202","djalil007_dz@yahoo.fr",[41],{"facility":42,"status":17,"city":43,"state":17,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Private Dental Clinic, Constantine","Constantine","25000","Algeria","DZ",{"type":48,"coordinates":49},"Point",[50,51],6.61472,36.365,{"lat":51,"lon":50},[54],{"name":55,"role":37,"phone":56,"phoneExt":17,"email":39},"Abdeldjalil Zitouni, Dental Surgeon","+213554040202",{"type":34,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Abdeldjalil ZITOUNI","Principal Investigator","100620402","oral-and-salivary-biomarkers-associated-with-stroke-100620402",false,"NCT07357155","Oral and Salivary Biomarkers Associated With Stroke","An Observational Study of Oral and Salivary Biomarkers Associated With Stroke","Inclusion Criteria:\n\n* Adults aged 18 to 90 years.\n* Patients diagnosed with stroke (ischemic or hemorrhagic) confirmed by clinical and imaging criteria for the stroke group.\n* Healthy volunteers without a history of stroke or cerebrovascular disease for the control group.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* inflammatory disease at the time of sampling.\n* Chronic autoimmune or malignant disease.\n* Recent major surgery or trauma within the last 3 months.\n* Pregnancy or breastfeeding.\n* Inability or refusal to provide saliva samples.",true,"ALL","18 Years","90 Years",{"count":72,"type":73},120,"ESTIMATED","OBSERVATIONAL","This observational study aims to explore the association between oral and salivary biomarkers and stroke. The study will include adult participants diagnosed with stroke and will analyze clinical, oral, and salivary parameters. The objective is to improve understanding of potential links between oral health, salivary biomarkers, and cerebrovascular disease. No experimental intervention will be performed.",[77],"Stroke",[77,79,80,81,82],"Oral health","Salivary biomarkers","Cerebrovascular disease","Observational study","NOT_YET_RECRUITING","2026-02-02",{"date":86,"type":87},"2026-02-05","ACTUAL",{"date":89,"type":73},"2026-03-20",{"date":91,"type":73},"2026-12",{"name":5,"class":6},1]