[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652377":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":28,"locations":34,"responsibleParty":60,"collaborators":27,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":27,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":27,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":87,"whyStopped":27,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of Aarhus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Galactose","EXPERIMENTAL","The patient will orally ingest 30 g of galactose.",[13],"Dietary Supplement: galactose",{"label":15,"type":16,"description":17,"interventionNames":18},"Galactose + Glucose","ACTIVE_COMPARATOR","The patient will orally ingest 30 g of galactose and 30 g of glucose.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","galactose","Participants undergo two experimental conditions in a randomized crossover design. In one condition, participants ingest 30 g of galactose, whereas in the other condition, they ingest 30 g of galactose combined with 30 g of glucose. The order of the conditions is randomized across participants.",[9,15],[26],"Galactose + glucose",null,[29],{"name":30,"role":31,"phone":32,"phoneExt":27,"email":33},"Ole Fuglsang-Jensen, master in sports science","CONTACT","+4527897650","AU664914@uni.au.dk",[35,50],{"facility":36,"status":27,"city":37,"state":27,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Aarhus Universitet","Aarhus","8000","Denmark","DK",{"type":42,"coordinates":43},"Point",[44,45],10.21076,56.15674,{"lat":45,"lon":44},[48],{"name":49,"role":31,"phone":27,"phoneExt":27,"email":27},"Ole Fuglsang-Jensen",{"facility":51,"status":27,"city":37,"state":27,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":52,"geoPoint":54,"contacts":55},"steno diabetes center Aarhus",{"type":42,"coordinates":53},[44,45],{"lat":45,"lon":44},[56],{"name":57,"role":31,"phone":58,"phoneExt":27,"email":59},"Esben Søndergaard, Professor","+45","esbensoe@rm.dk",{"type":61,"investigatorFullName":49,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Cand.Scient","100652377","oral-galactose-as-a-substrate-for-post-exercise-skeletal-muscle-glycogen-repletion-in-individuals-with-type-1-diabetes-100652377",false,"NCT07774780","Oral Galactose as a Substrate for Post-Exercise Skeletal Muscle Glycogen Repletion in Individuals With Type 1 Diabetes","Inclusion Criteria:\n\n* Healthy or T1D\n* BMI 18,5-30 kg\u002Fm2\n* Singed informed consent\n\nExclusion Criteria:\n\n* Clinically significant heart, lung, kidney, liver, endocrine, or malignant disease based on information collected during the initial screening visit as well as blood tests\n* Lack of awareness of hypoglycemia episodes\n* Blood donation within the last 3 months\n* Smoking\n* Alcohol or substance abuse\n* Participation in other studies involving ionizing radiation within the last 6 months\n* Claustrophobia\n* Inability to train one leg for one hour",true,"ALL","20 Years","70 Years",{"count":74,"type":75},16,"ESTIMATED","INTERVENTIONAL",[78],"NA","This Ph.D. project investigates whether orally ingested galactose can be taken up by skeletal muscle and the heart in response to exercise or hyperinsulinemia, and whether it may serve as a viable nutritional strategy for individuals with type 1 diabetes (T1D).\n\nAlthough exercise provides significant health benefits for people with T1D, it is often associated with substantial glucose fluctuations and an increased risk of hypoglycemia. Conventional carbohydrate strategies based on glucose may further exacerbate glycemic instability due to the rapid increase in blood glucose levels. In contrast, galactose is metabolized more slowly and may therefore provide a more stable energy source during and after exercise.\n\nPrevious research has demonstrated that intravenously administered galactose is taken up by human skeletal muscle, with uptake increasing during exercise, suggesting a mechanism that may be at least partly insulin-independent. Building on these findings, this project aims to determine whether similar uptake occurs when galactose is ingested orally.\n\nThis study uses a randomized controlled design and applies non-invasive 18F-FDGal PET imaging to quantify galactose uptake in skeletal muscle and cardiac tissue. The findings may contribute to improving dietary recommendations for individuals with T1D, particularly in relation to maintaining stable blood glucose levels during and after physical activity.",[81],"Type 1 Diabetes",[83,84,85,86],"Galactose metabolism","Skeletal muscle uptake of Galactose","Hepatic galactose uptake","Cerebral galactose uptake","NOT_YET_RECRUITING","2026-08-17",{"date":90,"type":91},"2026-08-19","ACTUAL",{"date":93,"type":75},"2027-02-01",{"date":95,"type":75},"2029-05-31",{"name":5,"class":6},2]