[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648231":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":48,"collaborators":23,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":23,"enrollmentInfo":62,"targetDuration":23,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":74,"whyStopped":23,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Konkuk University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ORI-Guided FiO2 Titration","ACTIVE_COMPARATOR","Fraction of inspired oxygen (FiO₂) is titrated using both the Oxygen Reserve Index (ORI) and peripheral oxygen saturation (SpO₂) during one-lung ventilation.",[13],"Other: ORI-Guided FiO2 Titration",{"label":15,"type":10,"description":16,"interventionNames":17},"Conventional SpO₂-Guided FiO₂ Titration","Fraction of inspired oxygen (FiO₂) is titrated using peripheral oxygen saturation (SpO₂) alone according to the institutional standard of care during one-lung ventilation.",[18],"Other: Conventional SpO₂-Guided FiO₂ Titration",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"During one-lung ventilation, FiO₂ is adjusted according to both ORI and SpO₂. FiO₂ is titrated to maintain SpO₂ ≥98% while keeping ORI above 0 to minimize hyperoxemia.",[9],null,{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":23},"During one-lung ventilation, FiO₂ is adjusted according to SpO₂ alone. FiO₂ is titrated to maintain SpO₂ ≥98% according to the institutional standard of care.",[15],[28,33],{"name":29,"role":30,"phone":31,"phoneExt":23,"email":32},"Tae-Yop Kim","CONTACT","82-10-8811-6942","taeyop@gmail.com",{"name":34,"role":30,"phone":23,"phoneExt":23,"email":35},"Chungsik Oh","iamchungsik@daum.net",[37],{"facility":5,"status":23,"city":38,"state":39,"zip":40,"country":41,"countryCode":23,"cosmosGeoPoint":42,"geoPoint":47,"contacts":23},"Seoul","Gwangjin-gu","05030","South Korea",{"type":43,"coordinates":44},"Point",[45,46],126.9784,37.566,{"lat":46,"lon":45},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Tae-Yop Kim, MD PhD","professor","100648231","ori-guided-oxygen-therapy-during-one-lung-ventilation-100648231",false,"NCT07720778","ORI-Guided Oxygen Therapy During One-Lung Ventilation","Effect of Oxygen Reserve Index-Guided Fraction of Inspired Oxygen Titration on the Incidence of Hyperoxemia During One-Lung Ventilation","ORI-OLV","Inclusion Criteria:\n\n* Adults aged ≥19 years\n* Scheduled for elective lung surgery requiring one-lung ventilation\n* Written informed consent\n\nExclusion Criteria:\n\n* Severe pulmonary hypertension.\n* Left ventricular systolic dysfunction.\n\nWithdrawal Criteria:\n\n* The participant or legally authorized representative requests withdrawal from the study.\n* An adverse event occurs that precludes continued participation in the study.\n* The planned surgery or study procedures are not performed (e.g., ORI monitoring is not applied or arterial blood gas analysis is not performed).\n* Perfusion Index is less than 2 during the study.\n* A major violation of the inclusion or exclusion criteria is identified after enrollment.\n* The participant fails to comply with the study protocol, potentially affecting the validity of the study outcomes.\n* Continued participation is considered not to be in the participant's best interest.\n* In the investigator's judgment, any other condition arises that makes continued participation inappropriate.","ALL","19 Years",{"count":63,"type":64},58,"ESTIMATED","INTERVENTIONAL",[67],"NA","High inspired oxygen concentrations (FiO₂) are commonly administered during general anesthesia to prevent hypoxemia. However, excessive oxygen administration may result in hyperoxemia, which has been associated with impaired hypoxic pulmonary vasoconstriction, increased oxidative stress, ventilation-perfusion mismatch, and postoperative pulmonary complications.\n\nDuring one-lung ventilation (OLV) for thoracic surgery, higher FiO₂ is often required because of increased intrapulmonary shunting, making hyperoxemia a frequent occurrence. The Oxygen Reserve Index (ORI) is a noninvasive pulse oximetry-derived parameter that reflects moderate hyperoxemia (PaO₂ approximately 100-200 mmHg) and may facilitate more precise oxygen titration than pulse oximetry alone.",[70],"Thoracic Surgery With One-lung Ventilation",[72,73],"One-Lung Ventilation","hyperoxia","NOT_YET_RECRUITING","2026-07-17",{"date":77,"type":78},"2026-07-22","ACTUAL",{"date":80,"type":64},"2026-08-01",{"date":82,"type":64},"2028-04-30",{"name":5,"class":6},1]