[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569108":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":24,"studyPopulation":25,"armGroups":26,"interventions":32,"overallOfficials":36,"centralContacts":41,"locations":47,"responsibleParty":388,"collaborators":20,"id":390,"slug":391,"hasResults":392,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":20,"eligibilityCriteria":396,"healthyVolunteers":392,"sex":397,"minAge":20,"maxAge":20,"enrollmentInfo":398,"targetDuration":20,"studyType":401,"phases":20,"briefSummary":402,"conditions":403,"keywords":20,"overallStatus":49,"whyStopped":20,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":417},{"fullName":5,"class":6},"Mayo Clinic","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Recurrence-free survival (RFS)","RFS is defined as the length of time after primary treatment that the patient survives without any signs or symptoms of that cancer. (Recurrence may be vaginal, hematogenous, lymphatic, or peritoneal.) RFS will be measured from the date of surgery to the date of recurrence, death, or last disease evaluation.","Up to 5 years",[14,17],{"measure":15,"description":16,"timeFrame":12},"Non-vaginal RFS","Non-vaginal RFS is defined as the interval from the date of surgery to the date of the first of the following events: non-vaginal recurrence or death due to any cause.",{"measure":18,"description":19,"timeFrame":12},"Overall Survival (OS)","Overall survival is defined as the time from surgery to death due to any cause.",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"COHORT","PROSPECTIVE","PRIMARY OBJECTIVE:\n\nI. To evaluate whether the likelihood of disease recurrence differs between a prospective cohort of patients with low-risk endometrial cancer with ITC and an historical cohort with negative SLNs.\n\nOUTLINE: This is an observational study.\n\nPatients undergo tissue sample collection and have their medical records reviewed on study.","Patients diagnosed with low-risk endometrial cancer.",[27],{"label":28,"type":20,"description":29,"interventionNames":30},"Observational","Patients undergo tissue sample collection and have their medical records reviewed on study.",[31],"Other: Non-Interventional Study",[33],{"type":6,"name":34,"description":34,"armGroupLabels":35,"otherNames":20},"Non-Interventional Study",[28],[37],{"name":38,"affiliation":39,"role":40},"Gretchen E. Glaser, MD","Mayo Clinic in Rochester","PRINCIPAL_INVESTIGATOR",[42],{"name":43,"role":44,"phone":45,"phoneExt":20,"email":46},"Clinical Trials Referral Office","CONTACT","855-776-0015","mayocliniccancerstudies@mayo.edu",[48,64,80,97,114,131,150,167,186,204,221,240,257,274,287,304,321,337,355,371],{"facility":39,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-92.4699,44.02163,{"lat":59,"lon":58},[62,63],{"name":43,"role":44,"phone":45,"phoneExt":20,"email":46},{"name":38,"role":40,"phone":20,"phoneExt":20,"email":20},{"facility":65,"status":49,"city":66,"state":66,"zip":67,"country":53,"countryCode":54,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Memorial Sloan Kettering Cancer Center","New York","10065",{"type":56,"coordinates":69},[70,71],-74.00597,40.71427,{"lat":71,"lon":70},[74,78],{"name":75,"role":44,"phone":76,"phoneExt":20,"email":77},"Christian Dagher","347-798-9213","dagherc@mskcc.org",{"name":79,"role":40,"phone":20,"phoneExt":20,"email":20},"Nadeem R. Abu-Rustum, MD",{"facility":81,"status":49,"city":82,"state":83,"zip":84,"country":53,"countryCode":54,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Houston Methodist Hospital","Houston","Texas","77030",{"type":56,"coordinates":86},[87,88],-95.36327,29.76328,{"lat":88,"lon":87},[91,95],{"name":92,"role":44,"phone":93,"phoneExt":20,"email":94},"Behrouz Zand","713-790-3311","bzand@houstonmethodist.org",{"name":96,"role":40,"phone":20,"phoneExt":20,"email":20},"Pedro T. Ramirez, MD",{"facility":98,"status":49,"city":99,"state":20,"zip":20,"country":100,"countryCode":101,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Medical University of Vienna","Vienna","Austria","AT",{"type":56,"coordinates":103},[104,105],16.37208,48.20849,{"lat":105,"lon":104},[108,112],{"name":109,"role":44,"phone":110,"phoneExt":20,"email":111},"Stephan Polterauer","+43 1 401600","stephan.polterauer@meduniwien.ac.at",{"name":113,"role":40,"phone":20,"phoneExt":20,"email":20},"Christoph Grimm, MD",{"facility":115,"status":49,"city":116,"state":20,"zip":20,"country":117,"countryCode":118,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"AC Camargo Cancer Center","São Paulo","Brazil","BR",{"type":56,"coordinates":120},[121,122],-46.63611,-23.5475,{"lat":122,"lon":121},[125,129],{"name":126,"role":44,"phone":127,"phoneExt":20,"email":128},"Louise De Brot","+55 11 2189-5000","louise.andrade@accamargo.org.br",{"name":130,"role":40,"phone":20,"phoneExt":20,"email":20},"Glauco Baiocchi, MD, PhD",{"facility":132,"status":49,"city":133,"state":134,"zip":135,"country":136,"countryCode":137,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"Sunnybrook Health Sciences, University of Toronto","Toronto","Ontario","M4N 3M5","Canada","CA",{"type":56,"coordinates":139},[140,141],-79.39864,43.70643,{"lat":141,"lon":140},[144,148],{"name":145,"role":44,"phone":146,"phoneExt":20,"email":147},"Stephanie Gill","+1 416-480-6100","zdis-stephanie.gill@uhn.ca",{"name":149,"role":40,"phone":20,"phoneExt":20,"email":20},"Allan Covens, MD",{"facility":151,"status":49,"city":152,"state":153,"zip":154,"country":136,"countryCode":137,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Hopital Maisonneuve Rosemont","Montreal","Quebec","H1T 2M4",{"type":56,"coordinates":156},[157,158],-73.58781,45.50884,{"lat":158,"lon":157},[161,165],{"name":162,"role":44,"phone":163,"phoneExt":20,"email":164},"Lara DeGuerke","+1 514-252-3400","lara.deguerke@gmail.com",{"name":166,"role":40,"phone":20,"phoneExt":20,"email":20},"Sabrina Piedimonte, MD",{"facility":168,"status":169,"city":170,"state":20,"zip":171,"country":172,"countryCode":173,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"Institut Universitaire du Cancer Toulouse Oncopole","NOT_YET_RECRUITING","Toulouse","31100","France","FR",{"type":56,"coordinates":175},[176,177],1.44367,43.60426,{"lat":177,"lon":176},[180,184],{"name":181,"role":44,"phone":182,"phoneExt":20,"email":183},"Alejandra Martinez","+33 5 31 15 50 50","martinez.alejandra@iuct-oncopole.fr",{"name":185,"role":40,"phone":20,"phoneExt":20,"email":20},"Giulio Ricotta, MD",{"facility":187,"status":169,"city":188,"state":20,"zip":189,"country":190,"countryCode":191,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"University Hospital Essen","Essen","45147","Germany","DE",{"type":56,"coordinates":193},[194,195],7.01228,51.45657,{"lat":195,"lon":194},[198,202],{"name":199,"role":44,"phone":200,"phoneExt":20,"email":201},"Rainer Kimmig","+49 201 7230","Rainer.Kimmig@uk-essen.de",{"name":203,"role":40,"phone":20,"phoneExt":20,"email":20},"Paul Buderath, MD",{"facility":205,"status":169,"city":206,"state":20,"zip":20,"country":207,"countryCode":208,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Meir Medical Center, Faculty of Medicine - Tel-Aviv University","Kefar Sava","Israel","IL",{"type":56,"coordinates":210},[211,212],34.90694,32.175,{"lat":212,"lon":211},[215,219],{"name":216,"role":44,"phone":217,"phoneExt":20,"email":218},"Yfat Kadan","+972 9-747-2555","yfat_ka@clalit.org.il",{"name":220,"role":40,"phone":20,"phoneExt":20,"email":20},"Mario Beiner, MD",{"facility":222,"status":169,"city":223,"state":224,"zip":225,"country":226,"countryCode":227,"cosmosGeoPoint":228,"geoPoint":232,"contacts":233},"Ospedale Michele e Pietro Ferrero","Verduno","CN","12060","Italy","IT",{"type":56,"coordinates":229},[230,231],7.93074,44.66614,{"lat":231,"lon":230},[234,238],{"name":235,"role":44,"phone":236,"phoneExt":20,"email":237},"Jessica Mauro","+39 0173 316111","jmauro@aslcn2.it",{"name":239,"role":40,"phone":20,"phoneExt":20,"email":20},"Alessandro Buda, MD",{"facility":241,"status":169,"city":242,"state":243,"zip":244,"country":226,"countryCode":227,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"IRCCS Fondazione San Gerardo dei Tintori","Monza","MB","20900",{"type":56,"coordinates":246},[247,248],9.27246,45.58005,{"lat":248,"lon":247},[251,255],{"name":252,"role":44,"phone":253,"phoneExt":20,"email":254},"Tommaso Grassi","+39 2331","grassi.tommaso88@gmail.com",{"name":256,"role":40,"phone":20,"phoneExt":20,"email":20},"Fabio Landon, MD",{"facility":258,"status":49,"city":259,"state":260,"zip":261,"country":226,"countryCode":227,"cosmosGeoPoint":262,"geoPoint":266,"contacts":267},"Fondazione IRCCS Istituto Nazionale Tumori","Milan","MI","20133",{"type":56,"coordinates":263},[264,265],12.59836,42.78235,{"lat":265,"lon":264},[268,272],{"name":269,"role":44,"phone":270,"phoneExt":20,"email":271},"Giorgio Bogani","+39 02 23901","giorgio.bogani@istitutotumori.mi.it",{"name":273,"role":40,"phone":20,"phoneExt":20,"email":20},"Francesco Raspagliesi, MD",{"facility":275,"status":49,"city":259,"state":260,"zip":276,"country":226,"countryCode":227,"cosmosGeoPoint":277,"geoPoint":279,"contacts":280},"European Institute of Oncology","20141",{"type":56,"coordinates":278},[264,265],{"lat":265,"lon":264},[281,285],{"name":282,"role":44,"phone":283,"phoneExt":20,"email":284},"Gabriella Schivardi","+39 02 574891","gabriella.schivardi@ieo.it",{"name":286,"role":40,"phone":20,"phoneExt":20,"email":20},"Francesco Multinu, MD",{"facility":288,"status":49,"city":289,"state":290,"zip":291,"country":226,"countryCode":227,"cosmosGeoPoint":292,"geoPoint":296,"contacts":297},"Policlinico Universitario Fondazione Agostino Gemelli","Roma","RM","00168",{"type":56,"coordinates":293},[294,295],11.10642,44.99364,{"lat":295,"lon":294},[298,302],{"name":299,"role":44,"phone":300,"phoneExt":20,"email":301},"Ilaria Capasso","+39 06 30151","capasso.ilaria@mayo.edu",{"name":303,"role":40,"phone":20,"phoneExt":20,"email":20},"Francesco Fanfani, MD",{"facility":305,"status":169,"city":306,"state":307,"zip":308,"country":226,"countryCode":227,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"University of Udine","Udine","UD","33100",{"type":56,"coordinates":310},[311,312],13.23715,46.0693,{"lat":312,"lon":311},[315,319],{"name":316,"role":44,"phone":317,"phoneExt":20,"email":318},"Tommaso Occhiali","+39 0432 556111","tommaso.occhiali@gmail.com",{"name":320,"role":40,"phone":20,"phoneExt":20,"email":20},"Giuseppe Vizzielli, MD, PhD",{"facility":322,"status":169,"city":323,"state":20,"zip":324,"country":226,"countryCode":227,"cosmosGeoPoint":325,"geoPoint":329,"contacts":330},"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale","Naples","80131",{"type":56,"coordinates":326},[327,328],14.26811,40.85216,{"lat":328,"lon":327},[331,335],{"name":332,"role":44,"phone":333,"phoneExt":20,"email":334},"Giuseppe Cucinella","+39 081 590 3111","giuseppecucinella@outlook.com",{"name":336,"role":40,"phone":20,"phoneExt":20,"email":20},"Vito Chiantera, MD",{"facility":338,"status":49,"city":339,"state":20,"zip":340,"country":341,"countryCode":342,"cosmosGeoPoint":343,"geoPoint":347,"contacts":348},"Hospital Materno Infantil Las Palmas","Las Palmas","35016","Spain","ES",{"type":56,"coordinates":344},[345,346],-16.16555,28.58232,{"lat":346,"lon":345},[349,353],{"name":350,"role":44,"phone":351,"phoneExt":20,"email":352},"Beatriz Navarro","+34 928 44 45 00","bea_0904@hotmail.com",{"name":354,"role":40,"phone":20,"phoneExt":20,"email":20},"Octavio Arencibia Sanchez, MD, PhD",{"facility":356,"status":49,"city":357,"state":20,"zip":358,"country":341,"countryCode":342,"cosmosGeoPoint":359,"geoPoint":363,"contacts":364},"Hospital Universitario La Paz","Madrid","28029",{"type":56,"coordinates":360},[361,362],-3.70256,40.4165,{"lat":362,"lon":361},[365,369],{"name":366,"role":44,"phone":367,"phoneExt":20,"email":368},"Alicia Hernandez","+34 917 27 75 76","aliciahernandezg@gmail.com",{"name":370,"role":40,"phone":20,"phoneExt":20,"email":20},"Ignacio Zapardiel, MD",{"facility":372,"status":49,"city":373,"state":20,"zip":374,"country":375,"countryCode":376,"cosmosGeoPoint":377,"geoPoint":381,"contacts":382},"Ospedale Regionale di Lugano, Civico","Lugano","6900","Switzerland","CH",{"type":56,"coordinates":378},[379,380],8.96004,46.01008,{"lat":380,"lon":379},[383,387],{"name":384,"role":44,"phone":385,"phoneExt":20,"email":386},"Andrea Papadia, MD, PhD","091 811 61 58","andrea.papadia@eoc.ch",{"name":384,"role":40,"phone":20,"phoneExt":20,"email":20},{"type":389,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100569108","outcomes-of-low-risk-endometrial-cancer-with-isolated-tumor-cells-in-the-sentinel-lymph-nodes-a-prospective-multicenter-single-arm-observational-study-100569108",false,"NCT06689956","Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: A Prospective, Multicenter, Single-Arm Observational Study","Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: a Prospective Multicenter Single-Arm Observational Study","Inclusion Criteria:\n\n* Low-risk endometrial cancer, defined as endometrioid, grade 1 or 2, International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA (FIGO 2023 stages IA1 and IA2), without substantial\u002Fextensive LVSI (≥ 5 vessels involved) at final pathology. Patients with focal LVSI (\\\u003C 5 vessels involved) will be included.\n\n  * Complete surgical staging, including pelvic sentinel lymph node (SLN) biopsy per National Comprehensive Cancer Network (NCCN) guidelines and ultrastaging.\n  * Extent of disease in SLN: ITC (defined as tumor cell aggregates ≤ 0.2 mm or \\\u003C 200 cells)\n  * No adjuvant treatment after surgery\n  * Research consent provided.\n\nExclusion Criteria:\n\n* Prior neoadjuvant chemotherapy.\n\n  * Planning to receive adjuvant treatment.\n  * Presence of synchronous cancer (excluding non-melanoma skin cancer).\n  * Extent of disease in SLN: micrometastasis (\\> 0.2 to ≤ 2.0 mm) or macrometastasis (\\> 2.0 mm).\n  * Presence of substantial\u002Fextensive LVSI (≥ 5 vessels involved) at final pathology.\n  * Prior invasive cancer diagnosis within 5 years of study entry (excluding non-melanoma skin cancer).","ALL",{"count":399,"type":400},212,"ESTIMATED","OBSERVATIONAL","This study evaluates whether isolated tumor cells in the first lymph nodes near the tumor can tell researchers something important about the future of patients with a certain type of endometrial (uterine) cancer.",[404,405,406,407],"FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma","FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma","Stage IA1 Endometrial Cancer FIGO 2023","Stage IA2 Endometrial Cancer FIGO 2023","2026-02-17",{"date":410,"type":411},"2026-02-19","ACTUAL",{"date":413,"type":411},"2024-12-04",{"date":415,"type":400},"2029-10-31",{"name":5,"class":6},20]