[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650064":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":33,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":69,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Postmenopausal",null,"Postmenopausal women, visits will take place during the menstrual phase, mid-follicular phase, ovulation, and mid-luteal phase, with a scheduling tolerance of ± 2days.",[13],"Other: Repeated assessments",{"label":15,"type":10,"description":16,"interventionNames":17},"Premenopausal","Premenopausal women, visits will take place during the menstrual phase, mid-follicular phase, ovulation, and mid-luteal phase, with a scheduling tolerance of ± 2days.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Repeated assessments","This study is an observational investigation involving repeated venous blood sampling and non-invasive clinical assessments ov four study visits.",[9,15],[24],{"name":25,"affiliation":26,"role":27},"Mirjam Christ-Crain, Prof. Dr. med.","University Hospital Basel Endocrinology, Diabetes and Metabolism","PRINCIPAL_INVESTIGATOR",[29],{"name":25,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","0041612652525","Mirjam.Christ-Crain@usb.ch",[34],{"facility":35,"status":10,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"University Hospital Basel","Basel","Canton of Basel-City","4031","Switzerland","CH",{"type":42,"coordinates":43},"Point",[44,45],7.57327,47.55839,{"lat":45,"lon":44},[48],{"name":25,"role":30,"phone":49,"phoneExt":10,"email":50},"+41 61 265 25 25","mirjam.christ-crain@usb.ch",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100650064","oxytocin-in-postmenopausal-women-100650064",false,"NCT07742124","Oxytocin in Postmenopausal Women","Circulating Oxytocin and Its Clinical Correlates in Postmenopausal Women Compared With Premenopausal Controls - The OxyMENO Study","OxyMENO","Inclusion Criteria:\n\n* Female sex at birth\n* Age ≥18 years\n\nPremenopausal group:\n\n• Premenopausal women aged 18-35 years with regular menstrual cycles (21-35 days) for ≥3 months prior to study entry\n\nPostmenopausal group:\n\n• Postmenopausal women ≥2 years of postmenopause (i.e. 3 years since last menstrual period (LMP), with menopause defined as ≥ 12 months of amenorrhea)\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Use of hormonal contraception or hormone replacement therapy within the last 3 months\n* Known endocrine disorders affecting the hypothalamic-pituitary-gonadal axis\n* Use of medications\n* Severe depression (BDI score \\> 28 points), any other severe psychiatric illness or acute medical disease\n* Inability to comply with study procedures\n* Participation in a trial with investigational drugs within the last 30 days","FEMALE","18 Years",{"count":64,"type":65},30,"ESTIMATED","OBSERVATIONAL","The aim of the present study is to assess whether cumulative endogenous neurophysin I secretion over one month differs between premenopausal and postmenopausal women. Using repeated measurements of neurophysin-I (NP-I, equimolar surrogate marker of oxytocin) across defined physiological time points, this study investigates oxytocin system regulation under cyclic and non-cyclic hormonal conditions.\n\nThe primary hypothesis is that cumulative NP-I release, expressed as the area under the curve (AUC) is lower in the postmenopausal group compared to the premenopausal group.",[9,15],[70,9,15,71,72,73],"Oxytocin","Neurophysin-I","cyclic hormonal condition","menstrual cyclic phase","NOT_YET_RECRUITING","2026-07-31",{"date":77,"type":78},"2026-08-03","ACTUAL",{"date":80,"type":65},"2027-06-01",{"date":82,"type":65},"2027-09-01",{"name":5,"class":6},1]