[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652153":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":37,"locations":45,"responsibleParty":73,"collaborators":75,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":30,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":30,"enrollmentInfo":88,"targetDuration":30,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":100,"overallStatus":106,"whyStopped":30,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"University of Minnesota","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Pacemaker Programming","ACTIVE_COMPARATOR","Participants randomized to this arm will receive standard pacemaker programming with a lower pacing rate of 60 beats per minute after permanent pacemaker implantation for bradycardia.",[13],"Device: Standard Pacemaker Programming",{"label":15,"type":16,"description":17,"interventionNames":18},"Physiologic Pacemaker Programming","EXPERIMENTAL","Participants randomized to this arm will receive individualized physiologic pacemaker programming between 60 and 90 beats per minute using the myPACE algorithm after permanent pacemaker implantation for bradycardia.",[19],"Device: Physiologic Pacemaker Programming",[21,27],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Individualized physiologic pacemaker programming between 60 and 90 beats per minute will be performed using the myPACE algorithm.",[15],[26],"myPACE Algorithm",{"type":22,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"Standard pacemaker programming with a lower pacing rate of 60 beats per minute will be used after permanent pacemaker implantation.",[9],null,[32,35],{"name":33,"affiliation":5,"role":34},"Selma Carlson, MD","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Markus Meyer, MD",[38,42],{"name":36,"role":39,"phone":40,"phoneExt":30,"email":41},"CONTACT","802-922-0656","markusmeyermd@gmail.com",{"name":43,"role":39,"phone":30,"phoneExt":30,"email":44},"Samantha Wansing","hoppx054@umn.edu",[46,65],{"facility":47,"status":30,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"M Health Fairview Clinics and Surgery Center","Minneapolis","Minnesota","55455","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-93.26384,44.97997,{"lat":57,"lon":56},[60,63,64],{"name":36,"role":39,"phone":61,"phoneExt":30,"email":62},"612-625-9538","meye3249@umn.edu",{"name":43,"role":39,"phone":30,"phoneExt":30,"email":44},{"name":36,"role":34,"phone":30,"phoneExt":30,"email":30},{"facility":66,"status":30,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},"University of Minnesota Medical Center",{"type":54,"coordinates":68},[56,57],{"lat":57,"lon":56},[71,72],{"name":36,"role":39,"phone":61,"phoneExt":30,"email":62},{"name":36,"role":34,"phone":30,"phoneExt":30,"email":30},{"type":74,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR",[76],{"name":77,"class":78},"Medtronic","INDUSTRY","100652153","pace-cognition-proof-of-concept-study-100652153",false,"NCT07769424","PACE Cognition Proof-of-Concept Study","Impact of Physiologic Pacemaker Programming on Cognitive Function and Health Status in Patients With Symptomatic Bradycardia","Inclusion Criteria:\n\n\\- Patient requiring a pacemaker for bradycardia\n\nExclusion Criteria:\n\n* Vulnerable adult unable to give consent\n* Unable to answer questionnaire\n* Children\n* Pregnant women\u002Fpersons\n* Prisoners\n* Adults lacking capacity to consent or adults with diminished or fluctuating capacity to consent\n* Non-English speakers\n* Individuals unable to read\n* Employees or students of the researcher\n* Active members of the military or DoD personnel","ALL","18 Years",{"count":89,"type":90},110,"ESTIMATED","INTERVENTIONAL",[93],"NA","This proof-of-concept study will evaluate whether physiologic pacemaker programming improves cognitive function and health status in patients with symptomatic bradycardia who require permanent pacemaker implantation.\n\nParticipants will be randomized to either standard pacemaker programming at 60 beats per minute or individualized physiologic rate pacing between 60 and 90 beats per minute using the myPACE algorithm. Cognitive function and health status will be assessed before pacemaker implantation and again at the routine 3-month pacemaker clinic visit.\n\nThe primary outcome is change in Montreal Cognitive Assessment total score. The secondary outcome is change in SF-36 mental component summary score.",[96,97,98,99],"Symptomatic Bradycardia","Cognitive Function","Pacemaker","Health Status",[101,102,103,104,105],"PACE Cognition","Symptomatic bradycardia","Physiologic pacing","Pacemaker programming","myPACE algorithm","NOT_YET_RECRUITING","2026-08-17",{"date":109,"type":110},"2026-08-19","ACTUAL",{"date":112,"type":90},"2026-10-01",{"date":114,"type":90},"2028-10-01",{"name":5,"class":6},2]