[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649853":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":10,"centralContacts":21,"locations":27,"responsibleParty":46,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"University of Catania","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Periodontitis",null,[12],"Other: Periodontal probing depth",{"label":14,"type":10,"description":10,"interventionNames":15},"Healthy controls",[12],[17],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"Periodontal probing depth","Periodontal probing depth measured in millimeters",[14,9],[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Gaetano Isola","CONTACT","0953785652","gaetano.isola@unict.it",[28],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":32,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"AOU Policlinico G. Rodolico","RECRUITING","Catania","Italy","95123","IT",{"type":36,"coordinates":37},"Point",[38,39],15.07041,37.49223,{"lat":39,"lon":38},[42,43],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},{"name":44,"role":24,"phone":25,"phoneExt":10,"email":45},"Rosalia Leonardi","rleonardi@unict.it",{"type":47,"investigatorFullName":23,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Prof.","100649853","periodontitis-on-gingival-crevicular-fluid-metobolomics-100649853",false,"NCT07739732","Periodontitis on Gingival Crevicular Fluid Metobolomics","Impact of Periodontitis on Metabolomics in Gingival Crevicular Fluid","Inclusion Criteria:\n\n1. Age between 18 and 70 years.\n2. Ability to understand the study procedures and provide written informed consent.\n3. For the periodontitis group: diagnosis of periodontitis according to the 2018 classification of periodontal diseases.\n4. For the healthy control group: periodontal health according to the 2018 classification, with no current diagnosis or history of periodontitis.\n\nExclusion Criteria:\n\n1. Periodontal treatment during the previous 6 months.\n2. Use of antibiotics, non-steroidal anti-inflammatory drugs, or immunosuppressive agents during the previous 6 months.\n3. Pregnancy.",true,"ALL","18 Years","70 Years",{"count":61,"type":62},60,"ESTIMATED","OBSERVATIONAL","This cross-sectional observational study will compare the gingival crevicular fluid metabolomic profile of 30 adults with periodontitis and 30 periodontally healthy adults. Participants will undergo a periodontal examination and gingival crevicular fluid collection during a single study visit. Targeted metabolomic analysis will be used to identify differences between the two groups and associations with periodontal clinical parameters.",[9],"2026-07-28",{"date":68,"type":69},"2026-07-31","ACTUAL",{"date":71,"type":69},"2026-05-04",{"date":73,"type":62},"2026-12-18",{"name":5,"class":6},1]