[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645739":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":10,"responsibleParty":31,"collaborators":10,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":37,"acronym":38,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":10,"enrollmentInfo":42,"targetDuration":10,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":49,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":10},{"fullName":5,"class":6},"University College, London","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Major Abdominal Cancer Surgery Cohort",null,"Adults aged 18 years and over who are scheduled to undergo major elective abdominal cancer surgery and are already referred for routine pre-operative cardiopulmonary exercise testing (CPET). This is an observational cohort study; no study-specific treatment or intervention will be assigned. Participants will continue with their usual surgical and perioperative care. The study will collect additional blood samples, imaging assessments, CPET-derived metabolic data, wearable activity data, and routine clinical information to evaluate whether pre-operative metabolic inflexibility is associated with myocardial injury after non-cardiac surgery.",[13],"Other: Pre-operative Metabolic Inflexibility",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Pre-operative Metabolic Inflexibility","Pre-operative metabolic inflexibility will be assessed as an observational exposure using data from routine pre-operative cardiopulmonary exercise testing (CPET). CPET-derived measures of substrate utilisation, including fat and carbohydrate oxidation, will be used to evaluate the participant's ability to switch between energy sources during physiological stress. Additional blood-based metabolic, immune, and cardiac biomarker analyses may be used to further characterise metabolic phenotype. No treatment, procedure, or clinical management will be assigned or altered by the study.",[9],[20],{"name":21,"affiliation":5,"role":22},"John Whittle, MBBS, PhD","PRINCIPAL_INVESTIGATOR",[24,28],{"name":21,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+44 203 447 3390","j.whittle@ucl.ac.uk",{"name":29,"role":25,"phone":26,"phoneExt":10,"email":30},"Rosalyn Hawkins, MBChB","Rosalyn.hawkins.25@ucl.ac.uk",{"type":32,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100645739","perioperative-medicine---metabolic-inflexibility-as-a-mechanism-for-myocardial-injury-after-non-cardiac-surgery-100645739",false,"NCT07694453","PeriOperative Medicine - Metabolic Inflexibility as a Mechanism for Myocardial Injury After Non-Cardiac Surgery","POM-MIMICS","Inclusion Criteria:\n\n* Adults aged 18 or over\n* Scheduled for major elective abdominal cancer surgery with planned overnight admission\n* Scheduled for pre-operative CPET\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Less than 18 years old\n* Emergency surgery\n* Unable or unwilling to undergo CPET\n* Pregnancy\n* Active sepsis\n* End-stage organ failure (e.g. on dialysis)\n* Participants without the mental capacity to consent\n* Diagnosis of Type 1 Myocardial Infarction meeting the 4th Universal Definition criteria during the immediate pre-operative period. (Note: Added based on MINS definition context)","ALL","18 Years",{"count":43,"type":44},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether metabolic inflexibility, which means reduced ability of the body to switch between using fats and sugars for energy, is associated with myocardial injury after non-cardiac surgery (MINS) in adults undergoing major elective abdominal cancer surgery.\n\nThe main question it aims to answer is:\n\nDoes pre-operative metabolic inflexibility predict myocardial injury after non-cardiac surgery (MINS) within the first 72 hours after surgery?\n\nParticipants will continue with their usual surgical care and pre-planned CPET (which can measure metabolic flexibility). As part of the study, participants will:\n\n* Have additional blood samples taken before and after surgery\n* Have an echocardiogram and, where possible, muscle ultrasound\n* Wear a wrist-worn activity monitor before surgery\n* Have routine clinical and surgical information collected from their medical records\n* Receive a follow-up phone call around 90 days after surgery",[48],"MINS",[48,50,51,52,53,54,55],"metabolic flexibility","CPET","Cardiopulmonary Exercise Testing","abdominal cancer surgery","Perioperative medicine","Troponin","NOT_YET_RECRUITING","2026-07-13",{"date":59,"type":60},"2026-07-14","ACTUAL",{"date":62,"type":44},"2026-10-01",{"date":64,"type":44},"2030-10-01",{"name":5,"class":6}]